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Advantages of Saliva Sampling in Bioanalysis Using Microextraction by Packed Sorbent and Dried Saliva Spot with LC–MS–MSIn this article, two sample handling and sample preparation methods for saliva samples are presented and discussed. Both methods were applied for determining the presence of lidocaine in saliva.
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Untargeted LC–MS Lipidomics with Data Independent Acquisition using Sequential Window Acquisition of All Theoretical Fragment-Ion SpectraA focus on untargeted UHPLC–MS/MS lipidomics with data independent acquisition using SWATH technology. This article explores the wide-ranging potential and peculiarities of SWATH–MS hyphenated with UHPLC for the profiling of lipidomes of various biological samples.
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Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase ChromatographyTherapeutic peptides represent one of the fastest growing segments in the pharmaceutical market. To bring these products to the market in a consistent manner, high quality is a major concern and requires stringent quality control (QC) methods. This article discusses the potential of zwitterionic chiral ion-exchangers to support peptide analysis and quality control as a flexible complementary tool to monitor the stereochemical integrity and chemical modifications.
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Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase ChromatographyTherapeutic peptides represent one of the fastest growing segments in the pharmaceutical market. To bring these products to the market in a consistent manner, high quality is a major concern and requires stringent quality control (QC) methods. This article discusses the potential of zwitterionic chiral ion-exchangers to support peptide analysis and quality control as a flexible complementary tool to monitor the stereochemical integrity and chemical modifications.
Latest:
Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase ChromatographyTherapeutic peptides represent one of the fastest growing segments in the pharmaceutical market. To bring these products to the market in a consistent manner, high quality is a major concern and requires stringent quality control (QC) methods. This article discusses the potential of zwitterionic chiral ion-exchangers to support peptide analysis and quality control as a flexible complementary tool to monitor the stereochemical integrity and chemical modifications.
Latest:
Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase ChromatographyTherapeutic peptides represent one of the fastest growing segments in the pharmaceutical market. To bring these products to the market in a consistent manner, high quality is a major concern and requires stringent quality control (QC) methods. This article discusses the potential of zwitterionic chiral ion-exchangers to support peptide analysis and quality control as a flexible complementary tool to monitor the stereochemical integrity and chemical modifications.
Latest:
Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase ChromatographyTherapeutic peptides represent one of the fastest growing segments in the pharmaceutical market. To bring these products to the market in a consistent manner, high quality is a major concern and requires stringent quality control (QC) methods. This article discusses the potential of zwitterionic chiral ion-exchangers to support peptide analysis and quality control as a flexible complementary tool to monitor the stereochemical integrity and chemical modifications.
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Preview of Topics at HPLC 2016, Part 1: Why Effective HPLC Separations Are Critical for the Analysis of High-Complexity SystemsThis is the first of a four-part series of articles exploring current topics in separation science that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.
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High-Definition Screening for Boar Taint in Fatback Samples Using GC–MSHigh-definition screening by gas chromatography–mass spectrometry (GC–MS) is shown to be a viable option for the reliable identification of odorous compounds in pork.
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Identifying Markers of Quality in Curry Powder Using GC×GC–TOF-MSLaura McGregor, Stefan Koschinski, and Elinor Hughes, SepSolve Analytical Assessing aroma profiles with high-capacity sorptive extraction combined with GC×GC–TOF-MS and powerful data mining software.
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Mass Spectrometry goes MainstreamIntroducing the new Verity® 1900 MS Detector from Gilson. Find out how Gilson’s solution is allowing mass detection to move into the mainstream.
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Extraction of Cannabinoids from BrowniesCannabinoids are successfully extracted from a complex brownie matrix using the QuEChERS sample preparation technique, significantly reducing the presence of matrix interferences. The resulting clean samples are analyzed by GC–MS using a specialized deactivated GC column to provide heightened peaks for the cannabinoid compounds.
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Laser Diode Thermal Desorption Tandem Mass Spectrometry for Simultaneous Quantitation of Metformin and Sitagliptin in Mouse and Human Dried Blood SpotsAn exploration of LDTD-MS-MS and how it compares to HPLC–MS-MS techniques in terms of sensitivity, robustness, and speed in an in-vivo drug discovery application
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Determination of Beta-Blockers in Urine Using SFC/MSThis Application Note demonstrates the separation and quantification of beta-blockers, listed as prohibited substances by the World Anti-Doping Agency, in urine using the Agilent 1260 Infinity Analytical SFC System.
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Determination of Beta-Blockers in Urine Using SFC/MSThis Application Note demonstrates the separation and quantification of beta-blockers, listed as prohibited substances by the World Anti-Doping Agency, in urine using the Agilent 1260 Infinity Analytical SFC System.
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Determination of Hexavalent Chromium Cr(VI) in Drinking Water by Suppressed Conductivity DetectionDevelopment of an ion chromatography (IC) method using suppressed conductivity detection for the determination of Cr(VI) in drinking water.
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Determination of Chlorophenols in Water According to U.S. EPA Method 528Determination and quantification of water contamination by phenols using the Dionex AutoTrace 280 SPE instrument.
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Determination of Chlorophenols in Water According to U.S. EPA Method 528Determination and quantification of water contamination by phenols using the Dionex AutoTrace 280 SPE instrument.
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Rapid Determination of Nitrobenzenes in Drinking Water Using Automated SPE with GC-ECDAutomated Solid-phase extraction (SPE) with GC-ECD for the determination of 15 nitrobenzene compounds in finished drinking water using the automated Thermo Scientific™ Dionex™ AutoTrace 280 Solid Phase-Extraction instrument in conjunction with the Thermo Scientific™ TRACE™ 1310 gas chromatograph.
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Fast and Accurate Identification of Pesticides by Direct Analysis in Real Time (DART) Ionization with Orbitrap Mass SpectrometryA method incorporating direct analysis in real time (DART) ionization and Thermo Scientific™ Orbitrap™ high-resolution mass spectrometry for rapid analysis and identification of contaminating substances in water.
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A New PEG GC Column with Improved Inertness Reliability and Column LifetimeWAX type columns are the industry standard analyzing a wide range of compounds with polar functional groups. The new Agilent DB-WAX Ultra Inert GC column is presented.
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Lab-on-a-Chip GC for Environmental ResearchThe development of a microfabricated comprehensive GC that can be used as a portable measurement device.
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Preview of Topics at HPLC 2016, Part 2: New Materials for UHPLC Analysis of Monoclonal Antibody Drugs and Antibody–Drug ConjugatesThis is the second in a four-part series of articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.
Latest:
Preview of Topics at HPLC 2016, Part 2: New Materials for UHPLC Analysis of Monoclonal Antibody Drugs and Antibody–Drug ConjugatesThis is the second in a four-part series of articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.
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Combating Terrorism with Mass Spectrometry — Screening People for ExplosivesIn this article, we review the capabilities and challenges of deploying mass spectrometry (MS) to homeland security screening requirements. The fidelity of MS for chemical analysis is well accepted; however, the effectiveness of an overall system in real-world work environments depends on solving big challenges in sample collection, speed of analysis, and ease-of-use, and maintaining continuous reliability. We compare MS to the more commonly used security method of ion mobility spectrometry (IMS) and illustrate the significant improvements that MS can provide. We then describe one of the first introductions of MS in homeland security, that being the screening of people for concealed explosives using a walk-through portal device.
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High-Speed Chromatography Results — A New Solution for Working with UHPLC DataThis article describes a new workflow technology in a chromatography data system (CDS) software program. Using this workflow streamlines workflows in chromatography laboratories, enabling users to set-up sequences, process data, and report results in the shortest possible time. This typically speeds up the generation of results, thus, more than matching typical throughput increases found when using UHPLC technology.
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Evolving Chromatography Software to Meet the Growing Needs for Mass Spectrometry Detection in the Analytical LaboratoryThis article discusses how chromatographer's toolkits have evolved.
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Evolving Chromatography Software: Using Standards to Create an Analytical Software EcosystemCommon systems for instrument control, data acquisition, and analysis would enhance the productivity of most laboratories greatly.
