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Deriving antibodies from plasma involves a multi-step process, from plasma collection to antibody purification and quality control, ensuring the final product is safe and effective for therapeutic, diagnostic, or research use. Krish Gosh, PhD, MBA, President of TCG Digital, joined LCGC International to discuss how AI/GenAI applications can optimize several steps to enhance yield, profitability, and process monitoring.

In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.

Solid Phase Extraction (SPE) is vital for chromatographic analysis. However, traditional loose-packed SPE products struggle with channelling and inconsistent resin mass, resulting in poor recovery and reproducibility. Discover how innovative composite technology overcomes these challenges to transform sample preparation, ensuring reliable and sensitive chromatographic data.

Raman spectroscopy is the ideal approach to compositional analysis and provides great versatility. In this Q&A, Tom Dearing, Senior Staff Scientist, and John Richmond, Senior Sales Manager, both at Thermo Fisher Scientific, provide an overview of the MarqMetrix All-In-One Process Raman Analyzer.

The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.

Alicat™ Scientific releases the next generation of OEM flow controllers and meters.

When it comes to high-purity inorganic raw materials, the key to analytical success is knowing how to define purity. A variety of factors can impact this definition, including the specific application as well as the chemist’s needs.

The EZGC and EZLC Online Software Suite are free web tools focused on helping cut method development time and costs dramatically by using highly accurate simulated separations and translations.

In this episode, “LC Column Hardware Evolution and its Role in Sustainability” brought to you by Advanced Materials Technology, Brett Paull Ph.D., Director of the ARC Training Centre for Hyphenated Analytical Separation technologies (HyTECH) at the University of Tasmania discusses the relationship of HPLC column technology and sustainability at the laboratory level.

Mistakes in the QC lab come in many forms: forgotten samples, incorrect solvent levels, or not verifying correct system performance. These mistakes can lead to repeated procedures and possibly time-consuming investigations, compromising lab productivity and efficiency. When combined, the Alliance iS HPLC System and Empower Software version 3.8.0 provide several new features designed to reduce errors and improve productivity in QC labs. Join Neil Lander and Denise Heyburn as they provide an overview of the top three advanced capabilities unlocked by combining the intuitively simple Alliance iS HPLC System with the latest version of Empower Software.

Pharmaceutical science has used the same slow analytical quality testing techniques for more than 40 years. Dr. Fred Regnier, CTO of Novilytic and one of the world’s top analytical chemists, explains how a new method is being utilized to expedite the molecular analysis of antibodies and to eliminate sample prep and mass spectrometry.

MALS detection coupled with AEX chromatography can aid in the characterization of AAVs.

Joseph Glajch, Ph.D., shares his expert perspective on the future of LC bio separations, hinting at the exciting possibilities that lie ahead for this transformative field.

James Edwards, an Application Scientist and Chromatographer at Porvair Sciences, discusses the challenges and advancements in solid-phase extraction (SPE) as a sample preparation technique for chromatography.

Polymers are gaining more attention in many new fields such as pharmaceutical applications. However, optimizing the final properties of the polymers associated with these new application areas is challenging for chemists and analysts. Polymer architecture plays a crucial role to optimize the end use or process-related properties. Size exclusion chromatography in combination with advanced detectors such as light scattering, viscometer, and refractive index is a powerful tool for the comprehensive characterization of macromolecules with various architectures. In this podcast, Dr. Subin Damodaran will explain how to understand the structural properties of a polymer by providing their molecular sizes such as radius of gyration (Rg ) and hydrodynamic radius (Rh), and intrinsic viscosity.

Quantitative measurement of biotherapeutic and clinically important biomarker proteins using LC-MS/MS has seen great development in the last 15 years. Stable Isotope Labelled Internal Standards are a cornerstone of accurate quantitation and there are several options ranging from signature peptides to “winged” longer peptides or full 13C and/or 15N labelled proteins to choose from. In this video Kevin Ray, Kwasi Mawunyega and Anders Fridstrom will discuss pros and cons with different SIL IS approaches as well as similarities and differences between biopharmaceutical bioanalysis and biomarkers for disease research & diagnosis.

Quantitative measurement of biotherapeutic and clinically important biomarker proteins using LC-MS/MS has seen great development in the last 15 years. Stable Isotope Labelled Internal Standards are a cornerstone of accurate quantitation and there are several options ranging from signature peptides to “winged” longer peptides or full 13C and/or 15N labelled proteins to choose from. In this video Kevin Ray, Kwasi Mawunyega and Anders Fridstrom will discuss pros and cons with different SIL IS approaches as well as similarities and differences between biopharmaceutical bioanalysis and biomarkers for disease research & diagnosis.