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Top articles published this week highlight several important analytical techniques, including LC–MS/MS and QuEChERS–GC–MS/MS.

A chromatographic approach based on isotope dilution high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) was used to objectively quantify serum cotinine as a biomarker of environmental tobacco smoke exposure in non-smoking women. The findings highlight the value of HPLC–MS/MS chromatography for sensitive biomarker quantification in epidemiological studies and support the role of second-hand smoke as a modifiable risk factor for pelvic inflammatory disease.

A spatially resolved proteomics workflow was established by combining nanosecond mid-infrared laser layer-by-layer ablation of human corneal tissue with liquid chromatography–tandem mass spectrometry (LC–MS/MS). The approach provided insights into metabolic activity, immune function, and wound-healing processes within individual corneal layers, demonstrating the power of LC–MS/MS-based chromatography for elucidating corneal biology, disease mechanisms, and potential pharmacological targets.

Thermo Fisher Scientific has entered a strategic collaboration with NVIDIA to integrate advanced AI technologies into scientific instruments and laboratory workflows.

A validated chromatographic method was developed for monitoring organochlorine pesticide residues in sesame seeds using QuEChERS sample preparation coupled with gas chromatography–tandem mass spectrometry (GC–MS/MS). The results demonstrate that QuEChERS combined with GC–MS/MS in multiple reaction monitoring (MRM) mode provides a robust, efficient, and reliable chromatographic solution for routine food safety monitoring and regulatory compliance in sesame seed analysis.

Waters Corporation has announced that its shareholders approved the issuance of Waters common stock to shareholders of Becton, Dickinson and Company (BD) in connection with the proposed combination of BD’s Biosciences and Diagnostic Solutions business with Waters.

A comprehensive analytical strategy combining inductively coupled plasma mass spectrometry (ICP-MS) with untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) was applied to evaluate the chemical composition of commercially available tattoo inks in Australia. The results demonstrate the critical role of LC–MS/MS-based chromatography in uncovering previously uncharacterized toxicants in tattoo inks and underscore the need for harmonized regulatory frameworks and routine chromatographic surveillance to ensure consumer safety.

Rapid native hydrophobic interaction chromatography–mass spectrometry methods have been developed using ammonium tartrate, enabling robust drug-to-antibody ratio and drug load distribution characterization, as well as real-time process analytical technology monitoring of antibody–drug conjugates bioconjugation without complex multidimensional workflows. LCGC International spoke to Bingchaun Wei of the research team about these methods.

Top articles published this week include an interview about a label-free quantitative native proteomics workflow and a preview of the upcoming 44th International Symposium on Capillary Chromatography (ISCC) and the 21st GC×GC Symposium.

Luigi Mondello and leading lights from the organizing team spoke with LCGC International about the return of the 44th International Symposium on Capillary Chromatography (ISCC) and the 21st GC×GC Symposium, to be held May 17–22, 2026, at the Conference Centre in Riva del Garda, Italy, and why this is an essential event for the global separation science community.

Restek Corporation has launched its next-generation RMX gas chromatography (GC) columns incorporating a new TriMax deactivation technology onto the market.

Researchers evaluated the antibacterial activity of shiitake mushroom extracts prepared with different solvents and characterized their bioactive constituents using gas chromatography–mass spectrometry (GC–MS). Ethyl acetate extracts showed the strongest antibacterial effects against multiple pathogens, while chromatographic analysis identified ergosterol and linoleic acid as key antimicrobial contributors.

In a valproic acid–induced autism rat model, voluntary exercise improved social and cognitive behaviors by reshaping gut microbiota and metabolic signaling. Gas chromatography (GC) and liquid chromatography-mass spectrometry (LC–MS)–based chromatographic analyses revealed exercise-driven changes in short-chain fatty acids and neurotransmitters, with fecal microbiota transplantation reproducing these behavioral and metabolic benefits.