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The History of Slalom Chromatography
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The History of Slalom Chromatography
2 days ago
by
Fabrice Gritti
What are NADES? Making Science Sustainable
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What are NADES? Making Science Sustainable
6 days ago
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Kate Jones
How Green Solvents are Revolutionizing Food Safety Analysis
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How Green Solvents are Revolutionizing Food Safety Analysis
7 days ago
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Kate Jones
Addressing Persistent, Mobile, and Toxic Compounds
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Addressing Persistent, Mobile, and Toxic Compounds
14 days ago
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Kate Jones
Tackling Complex Molecules in the Lab
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Tackling Complex Molecules in the Lab
20 days ago
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Kate Jones
Future Trends in the Laboratory
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Future Trends in the Laboratory
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Kate Jones
Key Application Areas for 2026
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Key Application Areas for 2026
a month ago
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Kate Jones
The Future of Column Technology
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The Future of Column Technology
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Kate Jones
Bringing FFF to Industry
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Bringing FFF to Industry
a month ago
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Kate Jones
3 Biggest Advances in GC and GC-MS
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3 Biggest Advances in GC and GC-MS
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Caroline Hroncich

The Column December Issue

A Look at the Latest Applications, Articles, and Interviews from the World of Chromatography

The Column December Issue

Challenges and Solutions in Oligonucleotide Analysis

An Overview of LC Methods and Applications

Challenges and Solutions in Oligonucleotide Analysis

LCGC International November/December Issue

Read the Latest Cutting-Edge Articles from LCGC

LCGC International November/December Issue

The Present and Future of Automation in Analytical Laboratories

Where Are We Heading?

The Present and Future of Automation in Analytical Laboratories

Chromatography Basics

Mastering Theoretical Plates for Better Separations

Chromatography Basics

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A chromatographic approach based on isotope dilution high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) was used to objectively quantify serum cotinine as a biomarker of environmental tobacco smoke exposure in non-smoking women. The findings highlight the value of HPLC–MS/MS chromatography for sensitive biomarker quantification in epidemiological studies and support the role of second-hand smoke as a modifiable risk factor for pelvic inflammatory disease.

A spatially resolved proteomics workflow was established by combining nanosecond mid-infrared laser layer-by-layer ablation of human corneal tissue with liquid chromatography–tandem mass spectrometry (LC–MS/MS). The approach provided insights into metabolic activity, immune function, and wound-healing processes within individual corneal layers, demonstrating the power of LC–MS/MS-based chromatography for elucidating corneal biology, disease mechanisms, and potential pharmacological targets.

A validated chromatographic method was developed for monitoring organochlorine pesticide residues in sesame seeds using QuEChERS sample preparation coupled with gas chromatography–tandem mass spectrometry (GC–MS/MS). The results demonstrate that QuEChERS combined with GC–MS/MS in multiple reaction monitoring (MRM) mode provides a robust, efficient, and reliable chromatographic solution for routine food safety monitoring and regulatory compliance in sesame seed analysis.

A comprehensive analytical strategy combining inductively coupled plasma mass spectrometry (ICP-MS) with untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) was applied to evaluate the chemical composition of commercially available tattoo inks in Australia. The results demonstrate the critical role of LC–MS/MS-based chromatography in uncovering previously uncharacterized toxicants in tattoo inks and underscore the need for harmonized regulatory frameworks and routine chromatographic surveillance to ensure consumer safety.

Rapid native hydrophobic interaction chromatography–mass spectrometry methods have been developed using ammonium tartrate, enabling robust drug-to-antibody ratio and drug load distribution characterization, as well as real-time process analytical technology monitoring of antibody–drug conjugates bioconjugation without complex multidimensional workflows. LCGC International spoke to Bingchaun Wei of the research team about these methods.

Researchers used Design of Experiments approach to optimize gas chromatography with flame ionization detection (GC–FID) for essential oil analysis. The harmonized GC method enables robust, reproducible separation of 87 terpenes using a single column and sample preparation protocol, improving efficiency, standardization, and sustainability for essential oil quality control.

Luigi Mondello and leading lights from the organizing team spoke with LCGC International about the return of the 44th International Symposium on Capillary Chromatography (ISCC) and the 21st GC×GC Symposium, to be held May 17–22, 2026, at the Conference Centre in Riva del Garda, Italy, and why this is an essential event for the global separation science community.

Researchers evaluated the antibacterial activity of shiitake mushroom extracts prepared with different solvents and characterized their bioactive constituents using gas chromatography–mass spectrometry (GC–MS). Ethyl acetate extracts showed the strongest antibacterial effects against multiple pathogens, while chromatographic analysis identified ergosterol and linoleic acid as key antimicrobial contributors.

In a valproic acid–induced autism rat model, voluntary exercise improved social and cognitive behaviors by reshaping gut microbiota and metabolic signaling. Gas chromatography (GC) and liquid chromatography-mass spectrometry (LC–MS)–based chromatographic analyses revealed exercise-driven changes in short-chain fatty acids and neurotransmitters, with fecal microbiota transplantation reproducing these behavioral and metabolic benefits.