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Conversations with Michael Dong: Buffers for Mobile Phase A in Pharmaceutical Analysis

Does SPE Improve LC–MS/MS Plant Hormone Analysis?

The Future of GLP-1 Peptide Analysis: AI, Automation, and the Scientist's Role

GC–MS Screens Leaf Extract for Lung Cancer Drugs

AI ML Now: Gert Desmet on the Future of Artificial Intelligence and Machine Learning in Separation Science

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Quantitative non-targeted screening with predicted response factors is not for regulation, but can rank environmental chemicals by concentration and toxicity.

Gert Desmet explores the current role of AI/ML in separation science.

Gas chromatography–mass spectrometry (GC–MS) reveals a four-stage polycyclic aromatic hydrocarbons (PAH) breakdown in oil sludge co-composted with manure.

This new high-performance liquid chromatography-ultraviolet (HPLC-UV) method measures glutathione and thiol levels across 12 berries.

Piotr Alvarez explains how HILIC complements reversed-phase LC for GLP-1 peptides, and why the field is moving toward MS-friendly TFA alternatives.

In this third part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses the retention mechanism of hydrophobic interaction.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows hydrogel cuts dogs' peak bupivacaine blood levels fivefold.

HILIC VS RP: Separating Impurities in Fatty-Acid-Conjugated siRNAs (Part 2)
In the second part of our interview, Novartis's Martina Lioi talks about using IP-HILIC and RP for lipid-siRNA impurities

LCGC International spoke to David Hage, Sanduni Heenkenda, and Zoe Zingler of the University of Nebraska-Lincoln about how green chemistry principles are reshaping affinity chromatography.

Panelists identify the parameters that make or break peptide method robustness and tech transfer, including temperature, flow rate, and dwell volume.

In Part 2 of "Conversations with Michael Dong," the LCGC column editor discusses HPLC columns for pharmaceutical analysis and the case for short columns.

Gas chromatography-mass spectrometry (GC–MS) shows scarlet macaw feather scent varies by sex and mate status.

Martina Lioi pairs IP-HILIC and RP to map impurities in fatty acid–linked siRNAs

Gas chromatography-mass spectrometry (GC–MS) reveals bisphenol A and other lasting pollutants in Maricá Lagoon (Brazil) sediments.

This week, Chromatography Online covered automated GC-MS/MS testing for phthalates in oils, chemicals hidden in bioplastic packaging, troubleshooting tips for oligonucleotides and GLP-1 peptides, automated glycan profiling, NIST reference materials, and the experience of being the only woman in the laboratory.




















