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A novel SFC–QTOF-MS method accurately detected 10 drugs in oral fluid, matching LC–MS/MS in 83 DUID cases while reducing run time by 42% and organic solvent use by 81%.

Supercritical fluid extraction (SFE) and high-pressure liquid chromatography (HPLC) team up to recover olive waste antioxidants. Marina Russo of the University of Messina (Italy) discusses the details.

Waters' Erin Chambers says combining column chemistry and particle-physics innovation cut a GLP-1 impurity profiling workflow from three hours to under one.

Analytical science's real unwritten rule is that you don't need to feel ready, and good results simply take patience.

Justin Miller-Schulze and Smith Purdum explain how machine learning and chemometrics can improve fire debris classification in forensic science applications.

Ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC-MS) reveals how temperature and life stage shift jellyfish venom.

Gas chromatography-mass spectrometry (GC-MS) chromatography reveals elevated polycyclic aromatic hydrocarbons (PAH) levels in wildfire smoke over Nevada.

As PFAS analysis pushes into trace-level territory, laboratories face a fast-moving mix of vast chemical scope, method fragmentation, and background contamination.

Best of the Week: National Forensic Science Week, and Chromatography Is On the Case
This week, the Chromatography Online website observed National Forensic Science Week with expert interviews on how chromatography helps solve cases, plus career stories from women in analytical science and new research on detecting rat poison in cats and tracking mold toxins in gluten-free pasta.

Kinjal Bhatt argues inclusion advocacy shouldn't fall on women alone, while Ina Varfaj credits sharing the load and learning to say no for avoiding burnout.

Steven Ray Wilson defines organ-on-a-chip as organoids on microfluidic devices, tracing their small, complex samples to the case for automated online LC–MS.

Liquid chromatography-mass spectrometry (LC-MS) detects Maillard byproducts in hay after steaming and storage.

Liquid chromatography-high resolution mass spectrometry (LC-HRMS) finds aflatoxin and fumonisins stay stable in gluten-free pasta.

Paper spray-mass spectrometry vs. liquid chromtography-tandem mass spectrometry (LC-MS/MS): Can rapid screening rival the gold standard in ER drug testing?

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) finds high fentanyl levels do not predict toxicity in tolerant users.




















