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Researchers have developed an advanced gas chromatography-mass spectrometry (GC–MS)-based chromatographic method for faster and more sensitive detection of volatile and semi-volatile PFAS in soil, improving environmental monitoring of “forever chemicals” and related contaminants. LCGC International spoke to Maria Chiara Corviseri and Flavio A. Franchina of the University of Ferrara, two of the authors of a paper presenting their method.

This "LC Troubleshooting" column discusses how inline mixing and feed injection mitigate solvent mismatch and peak distortion in liquid chromatography.

Exact mass, isotopic distribution, and MS/MS library matching are used together to differentiate PFAS hits from sulfur-rich food compounds that share a similar mass defect range.

Ion-exchange chromatography (IEC) revealed tree species-driven differences in soil carbon and microbial life.

This week, Chromatography Online compiled peer-reviewed research, expert interviews, and news articles spanning chromatography and spectrometry in food analysis.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed vitamin D deficiency strongly linked to childhood obesity.

Antonio Ferracane addresses regulator concerns about cleanup-free PAH methods, noting cleanup isn't mandatory if matrix validation proves reliable.

The approach remains non-targeted by prioritizing PFAS-like ions in the first DDA pass; the tunable mass tolerance window can be adjusted to capture structurally unusual PFAS subclasses.

Christine Fisher describes her method using mass defect filtering at the data acquisition stage to improve non-targeted PFAS detection in complex food matrices.

Blood markers reliably shifted toward healthy diet patterns after counseling.

Antonio Ferracane explains how each sample prep step adds error and can strip target PAHs, so skipping cleanup can improve recovery, accuracy, and precision.

Color imaging and high-performance liquid chromatography (HPLC) reliably predicted pigment levels in carrots.

Hydrophilic interaction chromatography-mass spectrometry (HILIC-MS) profiling tied a senescence gene region to chlorophyll loss and seed protein in sunflowers.