Process Analytical Technology (PAT)

Scientists from Politecnico di Milan in Milano, Italy created a new optimization approach for chromatographically purifying oligonucleotides.

For trace quantitative analysis, the splitless technique is most used as an inlet capable of performing both split and splitless injections. In this and upcoming installments, we take a closer look at splitless injection.

Here is some of the most popular content posted on LCGC International this week.

Sartorius recently announced the release of its new Vivaflow® Tangential Flow Filtration (TFF) Cassettes, which aim to streamline tangential flow filtration (TFF) in the laboratory.

Université d’Orleans and Chromisa Scientific scientists recently created a two-dimensional supercritical fluid chromatography (SFC) system with multiple heart-cutting (MHC) modes.

Polymer dispersions are used in numerous applications including paints, binders, and adhesives. These complex mixtures usually contain polymeric components that contribute significantly to their physical and chemical properties.

In a new study, scientists developed a new high-performance liquid chromatography (HPLC) system to optimize miniaturized liquid chromatography (LC).

Northwestern Polytechnical University scientists recently tested a new approach for integrating micro-lenses and slits into portable liquid chromatography (LC) systems.

Scientists from Roche Diagnostics in Germany are testing a new liquid chromatography (LC)-based approach for advancing process analytical technology (PAT) in biopharmaceutical processing.

Here are the top five articles that the editors of LCGC International published this week.

This article describes the contents and associated calculations of CoAs for small-molecule drugs. It explains how these documents help to ensure drug quality in the supply chain.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the Chinese Academy of Sciences recently tested out a new type of micro gas chromatographic column (µGCC) for separating light hydrocarbons.

Here are the top five articles that the editors of LCGC International published this week.

A team of scientists from Nanjing, China, have created a low-cost efficient online derivatization high-performance liquid chromatography (HPLC)-ultraviolet (UV) detector system, which they used to detect mono- and oligo-saccharides.

At the 2023 Gulf Coast Conference, LCGC spoke with Kevin Schug of the University of Texas at Arlington, about predicting gas phase vacuum ultraviolet spectra using machine learning. This interview was one of four conducted live at GCC 2023.

John Wasson, founder and president of Wasson-ECE Instrumentation, held a lecture at the Gulf Coast Conference in Galveston, Texas, which focused on the work his company is doing with process gas chromatographs (PGCs).

In this article, the author reviews how modern technology has changed laboratory science.

A study conducted by researchers at Rowan University explores column selection in compact capillary liquid chromatography (LC) systems.

Researchers compare the separation efficiency of olefins and paraffins using stationary phases containing silver(I) ions in ionic liquid (IL) and polymeric ionic liquid (PIL) matrices for gas chromatography techniques.

A new method for automatic z-axis correction during mass spectrometry imaging of uneven surfaces has been developed, allowing for accurate molecular analysis of complex samples. This advancement enhances the reliability and reproducibility of mass spectrometry imaging, enabling researchers to visualize the spatial distribution of molecules in challenging samples with uneven topographies.

This blog addresses the essential role software has in shaping the present and future of chromatography for the better.

At HPLC 2023, Dr. Joachim Richert held a plenary lecture about what steps need to be taken to reach true laboratory digitalization.

A new study reveals that real-time library searching significantly improves the structural characterization of glycerophospholipids and sphingomyelins, offering enhanced selectivity and comprehensive analysis. By utilizing real-time identifications to trigger targeted MSn analyses, researchers gain deeper insights into these crucial lipid species.

Researchers at Clemson University have developed a computational framework that integrates commercial software components to perform customizable technoeconomic feasibility analyses of monoclonal antibody capture chromatography platforms.

Incognito considers the future of laboratory training, questions the quality of current practices, and assesses the “easy wins” that can be learned across industries.

The use of a monolithic column reduces analysis time in an on-line biopharmaceutical HPLC analysis of granulocyte colony stimulating factor.

How to use these tools to develop an efficient and robust process

For PAT, you need to choose the right analytical methods. Here's how.

This paper outlines the current situation in manufacturing and quality operations relative to industry compliance initiatives and manufacturing challenges. It profiles an innovative ?method-centric? software platform, designed for the analyst or operator, to electronically execute and man-age quality control testing protocols and production batch records, yielding significant reductions in overall product release cycle time.