Author
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GC–MS Analysis of Heart-Cut Fractions During Evolved Gas Analysis of Polymeric MaterialsThe authors describe the characterization of polymers and additives using a novel heart-cut evolved gas analysis GC–MS method.
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Operational and Performance QualificationGuest authors discuss equipment qualification for good laboratory and manufacturing practices compliance.
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Operational and Performance QualificationGuest authors discuss equipment qualification for good laboratory and manufacturing practices compliance.
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Uncovering Deficiencies in Mass Balance Using HPLC with Chemiluminescence Nitrogen-Specific DetectionThe author describes using HPLC with chemiluminescence nitrogen-specific detection and aperometric detection to determine organic impurities in a tedisamil dihydrochloride drug substance.
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GC–MS Analysis of Heart-Cut Fractions During Evolved Gas Analysis of Polymeric MaterialsThe authors describe the characterization of polymers and additives using a novel heart-cut evolved gas analysis GC–MS method.
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High-Throughput Separations Using Multiplexed Capillary Electrophoresis with Laser-Induced Fluorescence DetectionThe authors evaluate the performance of multiplexed 96-lane CE with laser-induced fluorescence detection for high-throughput separation–based assays using fluorescein isothiocyanate as a model compound and fluorescein as an internal standard.
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High-Throughput Separations Using Multiplexed Capillary Electrophoresis with Laser-Induced Fluorescence DetectionThe authors evaluate the performance of multiplexed 96-lane CE with laser-induced fluorescence detection for high-throughput separation–based assays using fluorescein isothiocyanate as a model compound and fluorescein as an internal standard.
Latest:
High-Throughput Separations Using Multiplexed Capillary Electrophoresis with Laser-Induced Fluorescence DetectionThe authors evaluate the performance of multiplexed 96-lane CE with laser-induced fluorescence detection for high-throughput separation–based assays using fluorescein isothiocyanate as a model compound and fluorescein as an internal standard.
Latest:
High-Throughput Separations Using Multiplexed Capillary Electrophoresis with Laser-Induced Fluorescence DetectionThe authors evaluate the performance of multiplexed 96-lane CE with laser-induced fluorescence detection for high-throughput separation–based assays using fluorescein isothiocyanate as a model compound and fluorescein as an internal standard.
Latest:
High-Throughput Separations Using Multiplexed Capillary Electrophoresis with Laser-Induced Fluorescence DetectionThe authors evaluate the performance of multiplexed 96-lane CE with laser-induced fluorescence detection for high-throughput separation–based assays using fluorescein isothiocyanate as a model compound and fluorescein as an internal standard.
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Validation of Bioanalytical Capillary Gel Electrophoresis Methods for the Determination of OligonucleotidesGuest authors describe how this validation is performed routinely in their laboratory.
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On the Interpretation of GC × GC DataThe authors present their observations from developing data-handling software for GC × GC separations.
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Fused-Silica Capillary — The Story behind the TechnologyGuest author Steve Griffin identifies the fundamental problems in capillary manufacturing techniques that cause capillary defects and suggests some corrective actions.
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Validation of Bioanalytical Capillary Gel Electrophoresis Methods for the Determination of OligonucleotidesGuest authors describe how this validation is performed routinely in their laboratory.
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Validation of Bioanalytical Capillary Gel Electrophoresis Methods for the Determination of OligonucleotidesGuest authors describe how this validation is performed routinely in their laboratory.
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Validation of Bioanalytical Capillary Gel Electrophoresis Methods for the Determination of OligonucleotidesGuest authors describe how this validation is performed routinely in their laboratory.
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Validation of Bioanalytical Capillary Gel Electrophoresis Methods for the Determination of OligonucleotidesGuest authors describe how this validation is performed routinely in their laboratory.
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Practical Considerations of the Influence of Organic Modifiers on the Ionization of Analytes and Buffers in Reversed-Phase LCThis article provides theoretical background, experimental data, and practical considerations about the effects of organic modifiers on analyte ionization in reversed-phase LC.
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The Retention Behavior of Reversed-Phase HPLC Columns with 100% Aqueous Mobile PhaseThe authors studied the retention behavior of reversed-phase HPLC columns under 100% aqueous mobile-phase conditions.
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The Retention Behavior of Reversed-Phase HPLC Columns with 100% Aqueous Mobile PhaseThe authors studied the retention behavior of reversed-phase HPLC columns under 100% aqueous mobile-phase conditions.
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Practical Considerations of the Influence of Organic Modifiers on the Ionization of Analytes and Buffers in Reversed-Phase LCThis article provides theoretical background, experimental data, and practical considerations about the effects of organic modifiers on analyte ionization in reversed-phase LC.
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The Retention Behavior of Reversed-Phase HPLC Columns with 100% Aqueous Mobile PhaseThe authors studied the retention behavior of reversed-phase HPLC columns under 100% aqueous mobile-phase conditions.
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Ion Mobility Spectrometry (IMS): How It Works and Its Use in BiotechnologyIMS is a valuable tool for biopharmaceutical analysis. Two formats in particular have proven useful: cyclic IMS and structures for lossless manipulations (SLIM).
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Requirements for Validating a Capillary Isoelectric Focusing Method for Impurity QuantitationThe guest authors present a strategy for validating a capillary isoelectric focusing method intended to quantitate impurities in a protein drug substance.
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Requirements for Validating a Capillary Isoelectric Focusing Method for Impurity QuantitationThe guest authors present a strategy for validating a capillary isoelectric focusing method intended to quantitate impurities in a protein drug substance.
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Multidimensional Chromatography and the Signature Peptide Approach to ProteomicsThis article examines the role that multidimensional chromatography systems will play in high-throughput proteomics.
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Indirect Photometric Detection in CE Using Buffered Electrolytes — Part II, Practical RulesPart II of this series describes different ways electrolytes can be buffered while maintaining compatibility with indirect detection.
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Indirect Photometric Detection in CE Using Buffered Electrolytes — Part II, Practical RulesPart II of this series describes different ways electrolytes can be buffered while maintaining compatibility with indirect detection.
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Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
