Capillary Electrophoresis

Here is some of the most popular content posted on LCGC International this week.

Edinburgh Napier University and University of Helsinki scientists recently compared two techniques for their effectiveness in assessing drug passage through respiratory mucosa.

At HPLC 2024 in Denver, Colorado, various sessions will be led by experienced scientists, covering different aspects of chromatography techniques and maximizing their effectiveness. Here is some information about tomorrow’s sessions.

Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.

Scientists from Manipal Academy of Higher Education in India recently discussed different protein profile pattern analysis techniques and how they can help allow for universal screening.

Scientists from the Chinese Academy of Inspection and Quarantine recently published a review on how green solvents can further the evolution of microextraction techniques.

LCGC International sat down with Katarina Marakova to discuss her group’s work in top-down analysis of proteins using capillary zone electrophoresis–mass spectrometry (CZE–MS).

The advantages of a native anion exchange method coupled to mass spectrometry for charge heterogeneity analysis of immunoglobulin G4 (IgG4)-based mAbs are described.

At Pittcon 2024, LCGC International editor Patrick Lavery sat down with Wolfgang Lindner of the University of Vienna to talk about his career in liquid chromatography (LC).

A recent study examined how capillary electrophoresis (CE) could identify new 4-aryl-pyrido[1,2-c]pyrimidine derivatives in human serum.

Wolfgang F. Lindner and Martina Catani are the winners of the 17th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively. These awards honor the work of talented separation scientists at different stages in their career. The award winners will be honored in March in an oral symposium at the Pittcon 2024 conference in San Diego, California.

Scientists from the University of Calgary recently developed a novel method for externally adjusting the column length during gas chromatography (GC) operation.

This month we spoke to Zhuoheng Zhou from the Vrije Universiteit Brussel in Belgium about his research on advancing instrumental and column technologies for modern chromatography and its applications in novel biopharmaceutical modalities and proteomics.

Chromatography is predicted to be a major player among instrument technologies, but spectroscopy and electrophoresis may also increase their market shares.

Microfluidic capillary electrophoresis mass spectrometry (CE-MS) using ZipChip technology provides intact mass evaluations and efficient separation of oligonucleotides.

In this study, an efficient technique is described for extracting and quantifying barbiturates in serum samples, combining ultrasound and surfactant-assisted dispersive liquid–liquid microextraction (dLLME) with poly(ethylene oxide)-mediated stacking in capillary electrophoresis.

Professor Mary J. Wirth, W. Brooks Fortune Distinguished Professor Emerita at Purdue University, has been named the winner of the 2023 EAS Award for Outstanding Achievements in Separation Science.

An upcoming study revealed more information about the folding dynamics of i-motif DNA structures.

Scientists from the University of Maryland have created a system to analyze changes in a brain’s chief circadian pacemaker.

A recent study enhances capillary electrophoresis by streamlining the preparation process for linear polyacrylamide (LPA)-coated capillaries.

Small modifications to the way measurements are approached can enable reductions in the waste generated and carbon dioxide produced during an analysis.

The 27th International Symposium on Separation Sciences (ISSS 2023) will be held 24–27 September 2023 in Cluj-Napoca, Romania. Here’s a sneak preview of what attendees can look forwards to.

Researchers investigated a three-dimensional fluorinated covalent organic framework (3D-FCOF) as a stationary phase in capillary electrochromatography.

Microfluidic devices are considered ideal for fabricating portable diagnostic equipment for point-of-care testing, but substrates more environmentally friendly than glass or plastics are attracting interest.

Scientists at NACRW discussed using CE–MS to analyze highly polar agrochemicals.

Researchers have synthesized a chiral metal-organic framework (MOF) called L-histidine-zeolitic imidazolate framework-67 (L-His-ZIF-67) for enantioseparation of drugs in capillary electrochromatography. The chiral MOF demonstrated excellent separation efficiency for five chiral drugs, offering promising possibilities for pharmaceutical analysis and quality control.

Representatives of three subclasses of flavonoids were targeted for identification and quantitation in non-destructive single seed evaluation of Medicago sativa and Melilotus officinalis.

Researchers have discovered that the combined use of deep eutectic solvents (DESs) and amino acid-based ionic liquids (AAILs) with cyclodextrin-based chiral selectors can significantly enhance the chiral separation of amphetamine derivatives.

New MSPE-CE-DAD study indicates that efficiency remained above 75% even when a magnetic solid-phase extraction (MSPE) method was repeated five times, noting that the magnetic porous carbon (MPC) used in the extraction can be easily recycled.