Application Notes: LC-MS

This non-IP-RP method, using ammonium bicarbonate as mobile phase additive, is highly sensitive and suitable for the bioanalysis of therapeutic oligonucleotides.

The optimized LC-MS/MS method covering 388 signaling lipids shows that the bioinert coated YMC Accura Triart C18 column combines high sensitivity with high resolution.

In this application note, the charge variant characterisation of IgG4-based mAbs was performed using a BioPro IEX QF anion exchange column coupled to an MS detector.

The non-targeted screening of polar metabolites in human plasma with high sensitivity is achieved using a bioinert YMC Accura Triart Diol HILIC column.

The analysis of human plasma samples using a bioinert coated YMC Accura Triart C8 column demonstrates that real-life lipidomic analysis in under 10 minutes is possible.

This non-IP-RP method, using ammonium bicarbonate as mobile phase additive, is highly sensitive and suitable for the bioanalysis of therapeutic oligonucleotides.

This application note demonstrates the analysis of 9 halogenated acetic acids, which are regulated by the EPA and the European Union, using ICPMS/MS for detection.

The optimized LC-MS/MS method covering 388 signaling lipids shows that the bioinert coated YMC Accura Triart C18 column combines high sensitivity with high resolution.

HPLC coupled with negative ESI-MS provides a reliable method with unique capabilities for separation and identification of (therapeutic) oligonucleotides.

Microplastics in water are a major concern, found even in tap water and human bodies. Learn how Sartorius Arium® Pro VF series removes them effectively.

In this poster, we explore parameters that could impact data integrity with the analytes in EPA Method 1633, UCMR 5 and the EU Drinking Water Directive regulations.

Measuring ultrashort-chain PFAS (C1-C4) in water is crucial due to their ubiquity and potential human exposure. Standard RPLC tests struggle with these compounds.

Achieve exceptional peak shapes in LC-MS analysis of the challenging phospholipids LPC and PC with the bioinert coated YMC Accura Triart C18 columns.

Explore the game-changing benefits of the bioinert YMC Accura Triart C18 columns for phosphorylated peptide analysis to achieve reproducible results.

The non-targeted screening of polar metabolites in human plasma with high sensitivity is achieved using a bioinert YMC Accura Triart Diol HILIC column.

The analysis of human plasma samples using a bioinert coated YMC Accura Triart C8 column demonstrates that real-life lipidomic analysis in under 10 minutes is possible.

The analysis of 3 different RNA and DNA oligonucleotide mixtures demonstrates the supremacy of the bioinert coated YMC Accura Triart Diol-HILIC columns.

Measuring ultrashort-chain PFAS (C1-C4) in water is crucial due to their ubiquity and potential human exposure. Standard RPLC tests struggle with these compounds.

Crucial phosphorylated compounds can be analyzed by a polymeric iHILIC-(P) Classic HILIC column and MS. The method is applicable for targeted and non-targeted metabolomics.

In this short note, we will consider the selection of LC procedures to separate diniconazol enantiomers and show how data automation improves the process.

This application note discusses how to streamline method transfer outcomes using ACD/Labs' method development software, Method Selection Suite.

This application note demonstrates a novel composite technology that enhances reproducibility of solid phase extraction compared to a traditional loose packed format.

This app note outlines SPE extraction of water samples following EPA Draft Method 1634, comparing polymeric HLD SPE cartridges and polymeric HLB SPE cartridges.

In this short note, we will consider the selection of LC procedures to isolate ezetimibe from several of its degradants and show how data automation improves the process.

Crucial phosphorylated compounds can be analyzed via polymeric iHILIC-(P) Classic HILIC columns and MS. This is applicable for targeted and non-targeted metabolomics.

ZipChip-MS streamlines mAb charge variant characterization, eliminating the need for method development. Data is seamlessly processed in Byos. This note outlines an expeditious workflow for biosimilarity assessment among mAbs.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.

identification and quantification of 34 target PFAS at parts-per-trillion levels in pork, plus retrospective analysis of sample data files for other untargeted PFAS.

This application note outlines a QuEChERS method for the simultaneous analysis of cannabis for 67 pesticide and 5 mycotoxin residues in cannabis flower.

This application note explores the benefits of using LNI lab benches to enhance the performance of LC–MS systems.