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Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Multidimensional Chromatography and the Signature Peptide Approach to ProteomicsThis article examines the role that multidimensional chromatography systems will play in high-throughput proteomics.
Latest:
Multidimensional Chromatography and the Signature Peptide Approach to ProteomicsThis article examines the role that multidimensional chromatography systems will play in high-throughput proteomics.
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New Directions for Concentration Sensitivity Enhancement in CE and Microchip TechnologyNorberto Guzman and Ron Majors look at three areas in which progress has been made in improving concentration limits of detection for CE and CE microchip techniques: preconcentration methods, detector enhancements, and derivatization methods to improve separation selectivity and to enhance detection.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Scaling Gradient LC Methods to LC–MSThe authors focus on problems that may occur when converting conventional methods to LC–MS.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Method Validation Issues for the Resource Conservation and Recovery Act ProgramGuest author Barry Lesnik attempts to clarify the multiple uses of the term validation in environmental analysis.
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Optimizing Sample Preparation for Capillary Gel ElectrophoresisThis installment of "Directions in Discovery" describes experiments performed to optimize a standard quality-control method for protein purity evaluation using reducing capillary gel electrophoresis.
Latest:
Multidimensional Chromatography and the Signature Peptide Approach to ProteomicsThis article examines the role that multidimensional chromatography systems will play in high-throughput proteomics.
Latest:
Optimizing Sample Preparation for Capillary Gel ElectrophoresisThis installment of "Directions in Discovery" describes experiments performed to optimize a standard quality-control method for protein purity evaluation using reducing capillary gel electrophoresis.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
Analytical Procedures and Method Validation: Highlights of the FDA's Draft GuidanceThe FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.
Latest:
The Preparation of Calibration Standards for Volatile Organic Compounds — A Question of TraceabilityThis month's column looks at methods for preparing calibration standards for VOC analysis.
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Indirect Photometric Detection in CE Using Buffered Electrolytes — Part II, Practical RulesPart II of this series describes different ways electrolytes can be buffered while maintaining compatibility with indirect detection.
Latest:
Multidimensional Chromatography and the Signature Peptide Approach to ProteomicsThis article examines the role that multidimensional chromatography systems will play in high-throughput proteomics.
Latest:
Multidimensional Chromatography and the Signature Peptide Approach to ProteomicsThis article examines the role that multidimensional chromatography systems will play in high-throughput proteomics.
Latest:
Characterization and Source Identification of an Unknown Spilled Oil Using Fingerprinting Techniques by GC–MS and GC–FIDThis article describes a case study in which forensic chemical analyses were conducted to determine the liability for the release of an unknown petroleum product into a river.
Latest:
Characterization and Source Identification of an Unknown Spilled Oil Using Fingerprinting Techniques by GC–MS and GC–FIDThis article describes a case study in which forensic chemical analyses were conducted to determine the liability for the release of an unknown petroleum product into a river.
Latest:
New Environmental Applications of Accelerated Solvent ExtractionThe authors discuss two environmental applications for accelerated solvent extraction.
Latest:
Characterization and Source Identification of an Unknown Spilled Oil Using Fingerprinting Techniques by GC–MS and GC–FIDThis article describes a case study in which forensic chemical analyses were conducted to determine the liability for the release of an unknown petroleum product into a river.
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Development and Validation of an HPTLC Method for Determination of Aflatoxin B1A high performance thin-layer chromatographic (HPTLC) method was developed for the determination of aflatoxin B1 in cereals.
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The Problem of Late Elution — A Case StudyThis month's installment illustrates some potential problems that may arise during method transfer.
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Evaluating the Isolation and Quantification of Sterols in Seed Oils by Solid-Phase Extraction and Capillary Gas–Liquid ChromatographyThe authors describe two tests performed using SPE. The first involved sterol isolation and cleanup of seed oils, and the second analyzed crude seed oils.
Latest:
Evaluating the Isolation and Quantification of Sterols in Seed Oils by Solid-Phase Extraction and Capillary Gas–Liquid ChromatographyThe authors describe two tests performed using SPE. The first involved sterol isolation and cleanup of seed oils, and the second analyzed crude seed oils.
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A.A. Zhukhovitskii — A Russian Pioneer of Gas ChromatographyThis column discusses the activities of a Russian pioneer of GC and outlines the principles of some of the techniques he developed.
