Analytical Instrumentation

The new benchtop encloser can be equipped with interchangeable onboard air filtration options to protect samples from contamination or reduce user exposure to harmful chemical gases.

University College London scientists recently created a new technique for selecting two-dimensional liquid chromatography (2D-LC) columns.

Waters Corporation recently announced two new columns to their MaxPeak Premier Reversed-Phase Column portfolio during the conference in Washington, DC.

Here is some of the most popular content posted on LCGC International this week.

In this edition of “Inside the Laboratory,” Jillian Goldfarb of Cornell University discusses her laboratory’s work with using gas chromatography–mass spectrometry (GC–MS) to characterize compounds present in biofuels.

Researchers from Bristol Myers Squibb and Sanofi recently tested a new means of using hydrophobic interaction chromatography (HIC) for removing impurities in monoclonal antibodies (mAbs).

This paper describes the content of a well-written analytical procedure for regulated high-performance liquid chromatography (HPLC) testing. A stability-indicating HPLC assay for a drug product illustrates the required components for regulatory compliance, including additional parameters to expedite a laboratory analyst’s execution.

The article discusses the application of a hybrid organic/inorganic surface technology that forms a barrier between the sample and the metal surfaces of both the HPLC system and chromatographic column. Formed by a vapor deposition of an ethylene-bridged siloxane polymer on metal substrates), this technology effectively addresses common chromatographic challenges such as analyte loss, carryover, and peak tailing due to metal-analyte interactions. It improves peak symmetry and areas, as well as reproducibility, thereby not only benefiting challenging analytes but also increasing confidence in analytical results. We demonstrate the benefits of this technology through the analysis of B-group vitamins, steviol glycosides, and dextran oligosaccharides typically found in food, beverages, and dietary supplements, showcasing its critical role in improving chromatographic performance.

In this column, we look at the current version and the update of USP <621> on high-performance liquid chromatography (HPLC) that becomes effective 1st May 2025.

At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to Brett Paull from the University of Tasmania and HyTECH about his talk entitled: “Analytical Performance and Disruptive Potential of Fully Portable Portable and Field Deployable LC–MS Technology.”

Are you a chromatographer or a chromatography user?

In this edition of "The LCGC Blog," Jonathan Shackman discusses the differences between chromatographers and chromatography users, as well as advancements that have made chromatography a more accessible field.

A group of Malaysian and American scientists recently analyzed the benefits of using green metrics for detecting emerging contaminants (ECs) using analytical methods.

Splitless modes of operation using an optimized pulse injection are described.

A collaborative multi-analyte method developed utilizes HPLC and UHPLC to analyze more than 70 active ingredients. This method offers a validated approach for determining technical AI alongside linearity, precision, accuracy, and specificity tests for seven active ingredients.

Mary Ellen McNally and Doug Raynie covered green chemistry and sustainable separations, from sample preparation through analysis with chromatographic techniques, at EAS 2023.

The impact of contamination on each part of the inlet is examined.

The author discusses the benefits and challenges of using hydrogen in the laboratory, specifically regarding gas chromatography and GC–MS procedures.

Studies published over the last five years have focused on fully or semi-automated approaches and their applications in extraction of both organic and inorganic pollutants, while modern robotic tools and 3D printing are starting to make impacts.

This instalment explores the challenges involved in detecting the effluent from a capillary gas chromatographic column and summarizes the many detector options.

Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.

A new way to control ion transports in microfluidic systems has the potential to improve the technology and expand applications.

With Shimadzu Corporation's new location, the company hopes to innovate their research and technological efforts.

This comparison of various silica-based HILIC stationary phases with different types of coatings provides a better understanding of how stationary phase selectivity can be influenced.

When the unique shape-selective properties of PGC are appropriately identified, PGC stationary phases can be harnessed for fine separations of structurally related compounds.

An examination of the new high performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products that were introduced over the last year.

Given that artificial intelligence (AI) seems to be on everyone’s mind, it’s worth pausing to look at how AI works, and how it can fit into analytical chemistry.

This installment of Tips & Tricks will provide some helpful pointers to keep your GPC/SEC system in good shape.

With suspect PFAS screening becoming more popular, and the list of known PFAS now in the thousands, novel analytical tools are needed to generate transferable data sets. We highlight key updates here.