Author
Latest:
Validation of Impurity Methods, Part IISecond column in a series that reviews impurity method validation guidelines.
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Practical Aspects of Preparative HPLC in Pharmaceutical Development and ProductionThis month's installment discusses the practical aspects of the scale-up process and the problems and costs of preparative separations within a mid-sized pharmaceutical company.
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Practical Aspects of Preparative HPLC in Pharmaceutical Development and ProductionThis month's installment discusses the practical aspects of the scale-up process and the problems and costs of preparative separations within a mid-sized pharmaceutical company.
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The Benefits of Reversed Phases with Extended Polar Selectivity in Analyzing Wide-Polarity-Range SamplesThis article describes the use of phases with extended polar selectivity to reduce analysis time for wide-polarity-range samples such as an insecticide, simulated carboxylic acid degradants, and phthalate esters.
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A Volatile Ion-Pairing Chromatography Reagent for an LC–MS Mobile PhaseThis article presents a volatile ion-pairing reagent that enables good retention of highly polar anionic species using reversed-phase LC–MS.
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Mobile-Phase Buffers, Part III — Preparation of BuffersGuest author Tindall's final installment of a three-part series about buffers.
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Rapid Adeno-Associated Virus Genome Integrity Analysis by Capillary Gel ElectrophoresisIn this paper, two adeno-associated virus (AAV) genome integrity analysis workflows are introduced; a standard sample preparation protocol and an accelerated procedure, both utilizing capillary gel electrophoresis with laser induced fluorescent detection (CGE–LIF) to analyze the released nucleic acids.
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GC Instruments and Accessories at the 54th Pittsburgh ConferenceThe authors describe GC product introductions at Pittcon 2003.
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Comparison of an Evaporative Light-Scattering Detector and a Chemiluminescent Nitrogen Detector for Analyzing Compounds Lacking a Sufficient UV ChromophoreThe authors discuss the advantages and disadvantages of evaporative light-scattering detection and chemiluminescent nitrogen detection for determining compounds lacking UV chromophores.
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Membrane Extraction for Sample PreparationThe guest authors describe sample preparation techniques based on liquid membrane extraction.
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Mobile-Phase Cleanup Using Solid-Phase Extraction DisksThe authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
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Comparison of an Evaporative Light-Scattering Detector and a Chemiluminescent Nitrogen Detector for Analyzing Compounds Lacking a Sufficient UV ChromophoreThe authors discuss the advantages and disadvantages of evaporative light-scattering detection and chemiluminescent nitrogen detection for determining compounds lacking UV chromophores.
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Critical Pairs in Column Chromatography: A Primer for Pharmaceutical Method ValidationThis article reviews several common applications of the critical-pair approach to column chromatography as it is applied under pharmaceutical guidelines and validation strategies.
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Mobile-Phase Cleanup Using Solid-Phase Extraction DisksThe authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
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Mobile-Phase Cleanup Using Solid-Phase Extraction DisksThe authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
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Breaking Down Barriers: Can LC–MS Revolutionize the Quantitation of Drug Product Impurities?The authors test and compare performance of three types of LC–MS systems for precision, linearity, selectivity, accuracy, and sensitivity in the quantitation of drug impurities.
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Membrane Extraction for Sample PreparationThe guest authors describe sample preparation techniques based on liquid membrane extraction.
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Interactions of Enantiomers of Aromatic Amino Acids with Highly Sulfated CyclodextrinsThe author reports a comparative study of the interaction of aromatic amino acids with a class of highly sulfated cyclodextrins as the chiral selectors by capillary electrophoresis.
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Directions in Automated Sample Preparation of ProteinsThe guest authors discuss current procedures for protein sample preparation, protein analysis, and automation.
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Estimation of Triterpenes in Wines, Spirits, and Oak Heartwoods by LC–MSThe authors report the use of LC–MS for monitoring triterpenes in oak heartwoods, wines, and spirits.
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Intelligent Automation of LC–MS Analysis for the Characterization of Compound LibrariesThis article reports an approach to applying intelligent automation for high-throughput LC}MS analysis of compound libraries using Microsoft Visual Basic software.
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Microwave-Assisted Organic Extraction and Evaporation: An Integrated ApproachThe authors present integrated microwave extraction as an enhanced version of microwave-assisted solvent extraction in which solvents are optimized for chemistry and microwave absorption is modified using secondary microwave absorbers.
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Microwave-Assisted Organic Extraction and Evaporation: An Integrated ApproachThe authors present integrated microwave extraction as an enhanced version of microwave-assisted solvent extraction in which solvents are optimized for chemistry and microwave absorption is modified using secondary microwave absorbers.
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Microchip Electrophoresis and the Analysis of Polymerase Chain Reaction ProductsThe author compares chip-based electrophoretic methods with existing methods and competitors.
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Intelligent Automation of LC–MS Analysis for the Characterization of Compound LibrariesThis article reports an approach to applying intelligent automation for high-throughput LC}MS analysis of compound libraries using Microsoft Visual Basic software.
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GC–MS Analysis of Heart-Cut Fractions During Evolved Gas Analysis of Polymeric MaterialsThe authors describe the characterization of polymers and additives using a novel heart-cut evolved gas analysis GC–MS method.
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GC–MS Analysis of Heart-Cut Fractions During Evolved Gas Analysis of Polymeric MaterialsThe authors describe the characterization of polymers and additives using a novel heart-cut evolved gas analysis GC–MS method.
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An Efficient Approach to Column Selection in HPLC Method DevelopmentThe authors present an efficient, informed approach to HPLC column selection based upon complementary decisions regarding bonded-phase and particle physical characteristics.
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GC–MS Analysis of Heart-Cut Fractions During Evolved Gas Analysis of Polymeric MaterialsThe authors describe the characterization of polymers and additives using a novel heart-cut evolved gas analysis GC–MS method.
Latest:
GC–MS Analysis of Heart-Cut Fractions During Evolved Gas Analysis of Polymeric MaterialsThe authors describe the characterization of polymers and additives using a novel heart-cut evolved gas analysis GC–MS method.
