This article discusses how chromatographer's toolkits have evolved.
This article discusses how chromatographer's toolkits have evolved.
As the GC–MS market sees a trend toward high throughput and fast GC analyses, advances in data analysis software must be up to the task.
Extracting analytes from biological tissues often presents serious challenges for the analytical chemist. In this column, the guest authors provide an overview of human and animal tissue sample preparation, and compare conventional extraction technologies with novel approaches to these challenges.
The authors descrive the use of GC–MS to isolate and identify potentially toxic compounds in concentrated extracts of sewage treatment plant effluents.
Extracting analytes from biological tissues often presents serious challenges for the analytical chemist. In this column, the guest authors provide an overview of human and animal tissue sample preparation, and compare conventional extraction technologies with novel approaches to these challenges.
This month's column examines several possible causes of peak splitting and presents some guidelines for isolating the problem source.
Second column in a series that reviews impurity method validation guidelines.
This month's installment discusses the practical aspects of the scale-up process and the problems and costs of preparative separations within a mid-sized pharmaceutical company.
This month's installment discusses the practical aspects of the scale-up process and the problems and costs of preparative separations within a mid-sized pharmaceutical company.
This article describes the use of phases with extended polar selectivity to reduce analysis time for wide-polarity-range samples such as an insecticide, simulated carboxylic acid degradants, and phthalate esters.
This article presents a volatile ion-pairing reagent that enables good retention of highly polar anionic species using reversed-phase LC–MS.
Guest author Tindall's final installment of a three-part series about buffers.
In this paper, two adeno-associated virus (AAV) genome integrity analysis workflows are introduced; a standard sample preparation protocol and an accelerated procedure, both utilizing capillary gel electrophoresis with laser induced fluorescent detection (CGE–LIF) to analyze the released nucleic acids.
The authors describe GC product introductions at Pittcon 2003.
The authors discuss the advantages and disadvantages of evaporative light-scattering detection and chemiluminescent nitrogen detection for determining compounds lacking UV chromophores.
The guest authors describe sample preparation techniques based on liquid membrane extraction.
The authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
The authors discuss the advantages and disadvantages of evaporative light-scattering detection and chemiluminescent nitrogen detection for determining compounds lacking UV chromophores.
This article reviews several common applications of the critical-pair approach to column chromatography as it is applied under pharmaceutical guidelines and validation strategies.
The authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
The authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
The authors test and compare performance of three types of LC–MS systems for precision, linearity, selectivity, accuracy, and sensitivity in the quantitation of drug impurities.
The guest authors describe sample preparation techniques based on liquid membrane extraction.
The author reports a comparative study of the interaction of aromatic amino acids with a class of highly sulfated cyclodextrins as the chiral selectors by capillary electrophoresis.
The guest authors discuss current procedures for protein sample preparation, protein analysis, and automation.
The authors report the use of LC–MS for monitoring triterpenes in oak heartwoods, wines, and spirits.
This article reports an approach to applying intelligent automation for high-throughput LC}MS analysis of compound libraries using Microsoft Visual Basic software.
The authors present integrated microwave extraction as an enhanced version of microwave-assisted solvent extraction in which solvents are optimized for chemistry and microwave absorption is modified using secondary microwave absorbers.
The authors present integrated microwave extraction as an enhanced version of microwave-assisted solvent extraction in which solvents are optimized for chemistry and microwave absorption is modified using secondary microwave absorbers.