Ion Chromatography

Paris-Saclay University scientists used hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS) and inductively coupled plasma mass spectrometry (ICP-MS) to assess thorium’s interaction with peptides.

Ion chromatography can be utilized in various ways to analyze halogens and similar substances within inorganic matrices.

Scientists from the Henan Academy of Sciences recently developed a new technique for the determination of hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) from urine.

Scientists from the National Institutes for Food and Drug Control have characterized antibody-drug conjugates (ADCs) using various mass spectrometry (MS)-based techniques.

Scientists at the Indian Institute of Technology Delhi recently created a new machine learning (ML)-based tool for process verification during process chromatography unit operations.

Jiangsu Police Institute scientists recently created a solid-phase microextraction (SPME)-based method for determining amphetamine-type stimulants.

This article highlights a curated selection of the most popular GC-related content, with a focus on the diverse applications of the technique, as featured in LCGC.

Organic solvents are generally not compatible with ion chromatography (IC) systems. The approach presented here assists the use of organic solvents for sample preparation and provides a mechanism for the removal of the organic solvents from the chromatographic flow path.

This installment of Tips & Tricks focuses on the determination of the molar mass using a light scattering detector as an absolute detection method.

During EAS 2024, Jay Sheffer, a Product Specialist at Metrohm USA, discussed how combustion ion chromatography (CIC) can help address PFAS’ impact on the environment.

The method of standard additions (MoSA) enables quantification of volatile impurities in condensed-phase samples, such as emulsions, for which matrix-matched calibration standards are required. The technique is, however, expensive because it requires multiple analyses of each sample.

This article will discuss an ion-pair reversed-phase liquid chromatography mass spectrometry (IP-RPLC–MS) workflow for the characterization of three messenger RNA (mRNA) key critical quality attributes: 5’ Cap, ORF, and poly(A) tail.

Here is some of the most popular content posted on LCGC International this week.

Here is some of the most popular content posted on LCGC International this week.

This review aims to provide a summary of the most current analytical techniques and their applications in per- and polyfluoroalkyl substances (PFAS) research, contributing to the ongoing efforts to monitor and mitigate PFAS contamination.

Hydrophilic interaction chromatography–mass spectrometry (HILIC-MS) offers a flexible and efficient alternative to ion-pairing reversed-phase liquid chromatography (IP-RPLC) for oligonucleotide analysis, with column selectivity and mobile phase pH being key factors in optimizing retention and detection.

Scientists from Institut de Combustion, Aérothermique, Réactivité et Environnement (ICARE-CNRS) in Orléans, France and Chromatotec in Saint-Antoine, France recently created a new algorithm for detecting volatile organic compounds (VOCs) in ambient air.

Here is some of the most popular content posted on LCGC International this week.

Supercritical fluid extraction (SFE) was combined with supercritical fluid chromatography (SFC) hyphenated to mass spectrometry (MS) to analyze plastic additives that could be transferred into the environment from laboratory gloves.

Here is some of the most popular content posted on LCGC International this week.

Posters at the 2024 conference will feature research on a variety of topics from PFAS testing to the HPLC analysis of soft drinks.

Shangdong University and Shandong Energy Group scientists recently used HS-GC-IMS was used alongside machine learning algorithms to detect the geographic origins of coal associated with larceny cases.

Scientists from the Guangdong Academy of Sciences and the Guangdong University of Technology used nanospray laser-induced plasma ionization mass spectrometry (nLIPI-MS) to analyze broad polarity organic pollutants under ambient and open-air conditions.

Karlstad University scientists modeled pH-dependent retention and competitive adsorption of solutes using mixed-mode and reversed-phase liquid chromatography.

Waters Corporation scientists recently examined how different mobile and stationary phases affect small interfering RNA (siRNA) duplex stability in liquid chromatography.

University of Saskatchewan scientists analyzed phosphorus compounds in soil using two-dimensional ion chromatography-tandem mass spectrometry (2D-IC-MS/MS).

Scientists from Shanghai Jiao Tong University and the Sichuan China Tobacco Industry Company used gas chromatography-ion mobility spectrometry (GC-IMS) to analyze the flavor profiles of different cigars.

Connecticut Agricultural Experiment Station scientists recently used gas chromatography with flame ionization detection (GC-FID) to measure different components in cannabis hemp samples.

Here are the top five articles published on LCGC International this week.

Ion chromatography (IC) is becoming increasingly important for pharmaceutical applications. In contrast to other technologies, IC can resolve multiple ionic species and polar analytes simultaneously.