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Authentication and Routine Screening of Ginsenoside Isomers in Functional Food Products: UHPLC Coupled with Ion Mobility Mass SpectrometryGinseng has been used worldwide for thousands of years. Thought to possess therapeutic effects, it has been marketed as a natural product for the treatment of disease. This article describes how ultrahigh-performance liquid chromatography (UHPLC) can be coupled with ion mobility mass spectrometry (IMS-MS) to profile phytochemicals contained within ginseng and confirm quality.
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Yoshio Kato: In MemoriamDr. Yoshio Kato, a noted researcher in chromatography, has passed away. Kato was a quiet personality who presented scientific findings in simple, understandable words, and he was a good friend. He passed away at the end of August 2015, at the age of 70.
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Yoshio Kato: In MemoriamDr. Yoshio Kato, a noted researcher in chromatography, has passed away. Kato was a quiet personality who presented scientific findings in simple, understandable words, and he was a good friend. He passed away at the end of August 2015, at the age of 70.
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Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass SpectrometryThe US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.
Latest:
Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass SpectrometryThe US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.
Latest:
Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass SpectrometryThe US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.
Latest:
Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass SpectrometryThe US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.
Latest:
Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass SpectrometryThe US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.
Latest:
Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass SpectrometryThe US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.
Latest:
Combining Thermal Desorption GC and TOF-MS for the Determination of Melon VOC ProfilesA method based on thermal desorption with gas chromatography–time-of-flight mass spectrometry (GC–TOF-MS) can elucidate how key volatiles vary with the size of the melon pieces. Such analytical information is of value in efforts to improve the quality and safety of ready-to-eat foods.
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Hamish Small: Experimenter ExtraordinaireHamish Small spoke to AndrО Striegel about the secrets of his success in separation science, including the development of ion chromatography, and the value of vague thoughts in scientific progress.
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Ex Vivo Stabilization of Small Molecule Compounds and Peptides in EDTA Plasma for LC–MS-MS Analysis Using Frozen AliquottingThe ex vivo lability of some drug compounds and molecules in bio-analytical assays can add complexity and uncertainty to results and can pose significant challenges in drug development efforts. This can be especially true for compounds that are subjected to long-term cryogenic storage and that may need to be tested multiple times (for example, samples collected for clinical trials). Frozen aliquotting technology may offer a simple solution for stabilizing target compounds in frozen biological specimens, helping to streamline bio-analytical assay development and execution. The CXT 750 Frozen Sample Aliquotter, an automated instrument capable of generating quantitative aliquots of frozen plasma without thawing the sample, was evaluated at GlakoSmithKline for integration into biaonalytical workflows and the stabilization of labile compounds in EDTA plasma.
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GC–MS and UHPLC–MS-MS Analysis of Organic Contaminants and Hormones in Whale Earwax Using Selective Pressurized Liquid ExtractionHere we highlight some of the opportunities associated with combining advanced sample preparation techniques with state-of-the-art chemical analysis techniques. This article considers the unique combination of selective pressurized liquid extraction (SPLE) with gas chromatography coupled with mass spectrometry (MS) and ultra-performance liquid chromatography coupled with tandem MS-MS (UPLC-MS-MS). We use this powerful combination to develop a novel analytical technique capable of measuring hormones and organic contaminants in whale earwax plugs. We explore the analytical challenges with such combinations and the advantages of focusing both on sample preparation as well as instrumentation associated with chemical analysis.
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Gel Permeation Chromatography (GPC) for Process Control and Quality Control in Polyethylene and Polypropylene Manufacturing PlantsA method specifically developed to measure the molar mass distribution (MMD) of polyolefins in a manufacturing plant laboratory has been developed. It is demonstrated that the total cycle time, including the sample dissolution step, can be reduced to around 30 min, well in line with the process control requirements.
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The State of UK Separation ScienceWhat is the state of separation science in UK and what steps can be taken to promote the importance of the subject?
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Environmental Forensics in the WorkplacePopulations worldwide are exposed to polychlorinated biphenyls (PCBs) that can be harmful to human health. The Column spoke to David Megson from Ryerson University in Toronto, Canada, about recent developments in assessing human exposure to PCBs and chiral enantiomer fractions (EFs) in the workplace.
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Meeting Review: Advances in Microcolumn and Related Separation TechnologiesThe first meeting in The Chromatographic Society’s diamond anniversary year brought together world-renowned speakers alongside past presidents of the Society and delegates from academia, industry, and scientific instrument and technology companies at the Institute of Engineering and Technology in central London. The presentations included discussions on gas chromatography (GC), liquid chromatography (LC), capillary electrochromatography (CEC), and supercritical fluid chromatography (SFC) from both academic and industrial perspectives - providing valuable insight into contemporary trends in chromatographic techniques.
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Building Small But Thinking BigThe Column spoke to Brett Paull from the University of Tasmania in Hobart, Australia, about the development of truly portable LC systems for use in the pharmaceutical industry and in environmental analysis. Why are they necessary, and where can improvements still be made?
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Ghost Peak Investigation in a Reversed-Phase Gradient LC SystemHere is a step-by-step approach to investigate the source of ghost peaks in a gradient LC method.
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Lab-on-a-Chip GC for Environmental ResearchThe development of a microfabricated comprehensive GC that can be used as a portable measurement device.
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Separation Science in Drug Development, Part 4: Quality ControlThis fourth and last instalment in the “Separation Science in Drug Development” series provides an overview of modern practices of quality control in small-molecule drug development, including activities such as setting specifications, method validation and transfer, release and stability testing, and authoring chemistry, manufacturing, and controls (CMC) sections of regulatory filings.
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Meeting the Challenges of Bioanalysis with Time-of-Flight High Resolution Mass Spectrometry (TOF-HRMS)In an era where “more data in less time” is expected, bioanalytical scientists have had to become more resourceful. Consequently, bioanalytical laboratories are adopting and extending the use of high-resolution mass spectrometry (HRMS) and, in particular, time-of-flight high-resolution mass spectrometry (TOF-HRMS). One of the key benefits of TOF-HRMS is consistent resolution, sensitivity, and mass accuracy - even at high scan speeds with large molecules being analyzed.
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Analysis of Proteins, Biologics, and Nanoparticles in Biological Fluids Using Asymmetrical Flow Field-Flow FractionationAspects of applying AF4 to plasma, serum, milk, and cerebrospinal fluid in the field of analysis and characterization of proteins, biologics, and nanoparticles in biological fluids are reviewed.
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Practical Applications of Asymmetrical Flow Field-Flow Fractionation: A ReviewThis review highlights applications for which AF4 is particularly well suited, and explains when not to use the technique.
