Podcasts

Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.

In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias discuss highlights and observations from HPLC 2024, which was held in Denver, Colorado in July.

The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.

Purity is often viewed through the lens of the application or the chemist using a material. One level of purity can be good for a specific application and fail in another situation, making it a very relative benchmark. In this paper, we will discuss the importance of defining purity, impurities, and the situations in which high-purity inorganic raw materials are essential for analytical success.

Here in Episode #17, podcast host Dr. Jerry Workman speaks with Dr. Jake Shelley about the latest developments and research in the field of atomic spectroscopy.

In this episode, “Improving Chromatography of Basic Compounds” brought to you by Advanced Materials Technology, Stephanie Rosenberg, Director of Sales & Marketing discusses How utilizing the new HALO® positively charged surface columns impact the performance of LC and LCMS separations.

In this episode, “LC Column Hardware Evolution and its Role in Sustainability” brought to you by Advanced Materials Technology, Brett Paull Ph.D., Director of the ARC Training Centre for Hyphenated Analytical Separation technologies (HyTECH) at the University of Tasmania discusses the relationship of HPLC column technology and sustainability at the laboratory level.

Mistakes in the QC lab come in many forms: forgotten samples, incorrect solvent levels, or not verifying correct system performance. These mistakes can lead to repeated procedures and possibly time-consuming investigations, compromising lab productivity and efficiency. When combined, the Alliance iS HPLC System and Empower Software version 3.8.0 provide several new features designed to reduce errors and improve productivity in QC labs. Join Neil Lander and Denise Heyburn as they provide an overview of the top three advanced capabilities unlocked by combining the intuitively simple Alliance iS HPLC System with the latest version of Empower Software.

Pharmaceutical science has used the same slow analytical quality testing techniques for more than 40 years. Dr. Fred Regnier, CTO of Novilytic and one of the world’s top analytical chemists, explains how a new method is being utilized to expedite the molecular analysis of antibodies and to eliminate sample prep and mass spectrometry.

Adeno-associated viruses (AAVs) have recently gained significant attention in the field of gene and cell therapy. In this podcast, an overview of chromatography techniques for the characterization of AAVs will be discussed by Dr. Phu Duong. The discussion will highlight the most versatile and powerful detection technique to accurately characterize AAVs that is easy to adapt and implement.

In this episode of Trends in Modern Bio Separation Workflows brought to you by Advanced Materials Technology, Joseph Glajch Ph.D., President and Chief Consultant, JLP AP Consulting LLC,discusses how the landscape of bio separations has evolved, how monoclonal antibodies have dominated the market, the current challenges for research scientists and the tools available to them and lastly where he sees the future of LC bio separations.