Application Notes: Biological, Medical, and Clinical

Providing guidance for optimizing the analytical performance of sorbent tube sampling and thermal desorption–GC–MS for disease diagnosis via breath and bio-monitoring.

The unique design of the 50 cm μPAC™ GEN2 nanoLC column provides superior performance over state-of-the-art packed bed columns, achieving peak capacities of over 1000.

Antec Scientific ALEXYS FDG analyzer for seamless QC of the radiolabeled FDG and its by-products according to the European and US Pharmacopeia monographs.

In this application note we evaluate the benefits of Real-Time Search for SPS MS3 (Orbitrap Eclipse MS) to enhance TMT quantification accuracy and proteome coverage.

PharmaFluidics’ μPAC capLC is evaluated for different user needs ranging from 12 samples per day in comprehensive mode to 65 samples per day in throughput mode.

Overall gain in performance and increase in detection sensitivity that can be achieved for the separation of plant metabolite extracts by using µ¬PAC columns.

PharmaFluidics also offers a 50 cm long μPAC column which is perfectly suited to perform more throughput analyses with shorter gradient solvent times.

Analyzing skin ceramides using PharmaFluidics’ µPAC column technology reveals a substantial structural diversity and isomeric resolved sphingolipids.

Monitoring the excellent separation performance of PharmaFluidics’ µPAC columns by using peptide retention time calibration mixtures for bottom-up proteomics.

PharmaFluidics’ μPAC columns have the potential to be less prone to sample related column failure and to withstand more sample injections without losing performance.

When SEC does not provide optimal separation of proteins for characterization by multi-angle light scattering, MALS can be coupled to ion-exchange chromatography.

• Methods for sports doping control using high resolution mass spectrometry • Using HRMS, one GC–MS and LC–MS method offers efficient, accurate screening

This application note shows how to achieve higher recoveries for commercially available MAbs using 15 % isopropanol as modifier in HIC mode.

Shodex HILICpak VT-50 is suitable for the analysis of phosphorous-containing amino acids herbicids including glyphosate, glufosinate and their metabolites using ESI-MS detection.

Antibody molecular weight analysis can now be easily performed on the Shodex PROTEIN LW-803.

• Methods for sports doping control using high resolution mass spectrometry • Using HRMS, one GC–MS and LC–MS method offers efficient, accurate screening

Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.

Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.

Strata-X PRO consists of a new type of polymeric SPE sorbent combined with matrix removal technology to revolutionize sample extractions and matrix clean-up by eliminates the conditioning and equilibration steps.

This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.

Strata-X PRO consists of a new type of polymeric SPE sorbent combined with matrix removal technology to revolutionize sample extractions and matrix clean-up by eliminates the conditioning and equilibration steps.

This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.

Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.

Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.

Implementing a peptide screening SPE plate determines the appropriate choice for a wide range of chemically diverse peptides.

The optimized dual solid phase extraction (SPE) method was developed to significantly reduce the surfactant background from formulated drug products.

A HILIC solid phase extraction (SPE) and LC method that results in sensitive, effective, and a time savings for the clean-up of N-Glycans.

A fast analytical method including both sample preparation and LC–ƒMS/MS analysis of ibuprofen in human plasma.

Implementing a peptide screening SPE plate determines the appropriate choice for a wide range of chemically diverse peptides.