Mass Spectrometry

New research using matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) has revealed the distinct distributions of acetaminophen and its metabolite in the kidneys at an unprecedented resolution of 10 μm. The study, conducted by Mitsutoshi Setou and his team from Hamamatsu University School of Medicine in Japan, provides valuable insights into drug distribution and metabolism, enhancing our understanding of the pharmacokinetics and potential nephrotoxicity of acetaminophen.

Pop quiz – can you define resolution? Would you be surprised at the number of correct answers? Which one is the best for chromatographers? In this LCGC Blog, we look at the various ways resolution can be interpreted scientifically.

Levoglucosan, which is emitted from the combustion of cellulose and hemicelluloses, can be transported over a long range of time to ice caps, where it may indicate fire activity both regionally and globally.

Gas chromatography coupled to mass spectrometry (GC–MS) has been the gold standard in this application, but its limitations in differentiating cancer subtypes have led to the exploration of newer related technologies.

Researchers have discovered that phospholipids form doubly charged lipid-metal ion complexes during electrospray ionization (ESI), providing valuable insights into the analysis of phospholipid structures.

Researchers have developed an ultrahigh-pressure liquid chromatography (UHPLC)—tandem mass spectrometry (MS/MS) method for the simultaneous determination of 10 aminoglycoside antibiotics in aquatic products.

A recent study reveals that pesticide residues in herbs have a low transfer rate to herbal infusions, ensuring safer consumption of these products. The validated analytical method used in the study provides valuable insights into the levels of pesticide residues in herbs and their limited presence in the resulting infusions.

The subatmospheric pressure laser desorption ionization-mass spectrometry platform proposed here showed potential for mapping low-abundance biomarkers.

Researchers said they have devised a novel setup using a secondary electrospray ionization-high resolution mass spectrometry (SESI-HRMS) platform to detect bacterial cultures in cells that are vital to immune and memory functions.

Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.

A research team has developed a new approach for selecting precursor ions in tandem mass spectrometry (MS/MS) experiments called DiffN, which increases the likelihood of biomarker discovery and provides a promising tool for lipidomic analyses.

With the potential for compact mobile devices, interferometric mass spectrometry (Interf-MS) is a pioneering technique that utilizes quantum interference and wave-like properties of samples for mass separation, offering a high dynamic range and complementing traditional methods such as accelerator mass spectrometry (AMS).

In a lecture at HPLC 2023, Valérie Pichon of ESPCI Paris and Sorbonne University said these advances address limitations of more traditional extraction techniques.

In a presentation at HPLC 2023, Kevin Pagel of Freie Universität in Berlin, Germany described methods he has found most effective for better understanding the roles of glycans and glycoconjugates in biological processes.

At HPLC 2023, Paola Dugo held a lecture on how combining two-dimensional liquid chromatography (LC×LC) with mass spectrometry (MS) can help scientists analyze food samples.

At HPLC 2023, Erin Baker held a lecture on how using liquid chromatography and mass spectrometry together can help scientists further understand diseases that can arise from chemical exposure.

Webinar Date/Time: Day One: Monday, August 7th, 2023 9am EDT | 6am PDT | 2pm BST | 3pm CEST Day Two: Tuesday, August 8th, 2023 9am EDT | 6am PDT | 2pm BST | 3pm CEST

In his plenary lecture at HPLC 2023, Michal Holčapek presented his team's findings on how chromatography can help scientists record the human lipodome and better our understanding of diseases.

Gunda Köllensperger spoke at HPLC 2023 about how using U13C-isotopically labelled biomass extracts can change how scientists approach metabolomics.

In this HPLC 2023 keynote lecture, Mario Thevis discusses how chromatographic–mass spectrometric approaches have led to important advancements in sports drug testing programmes.

At HPLC 2023, Hyukju Kwon hosted a lecture on the roles LC–MS and artificial intelligence can have in autonomous material discovery.

At HPLC 2023, Valerie Gabelica of the Institut Européen de Chimie et Biologie said much is still unknown about this approach to mass spectrometry.

At HPLC 2023, Oliver Fiehn of the University of California explained results gathered from a device that can be used during daily digestion.

An ultrahigh-pressure liquid chromatography–tandem mass spectrometry method (UHPLC–MS/MS) using polarity switching, preceded by solid-phase extraction (SPE), was used to quantify eight ultraviolet filter (UVF) compounds in chlorinated outdoor pools in Winnipeg.

Fresh garlic and aged garlic, both brown and black, were all analyzed for their bioactives, in an attempt to expand those compounds’ applications as food ingredients and dietary supplements.

A new study reveals that real-time library searching significantly improves the structural characterization of glycerophospholipids and sphingomyelins, offering enhanced selectivity and comprehensive analysis. By utilizing real-time identifications to trigger targeted MSn analyses, researchers gain deeper insights into these crucial lipid species.

Researchers have discovered diacylglycerols as potent biomarkers for the rapid diagnosis of breast cancer, using mass spectrometry imaging. This breakthrough study offers new possibilities for improved intraoperative assessment and personalized treatment strategies.

Scientists have developed a breakthrough MDLC–MS method for in-depth characterization of charge variants in therapeutic antibodies. The innovative approach enables the detection and evaluation of rare charge variants, facilitating improved safety and efficacy in antibody development.

Organic acids, flavonoids, iridoids, and saponins were among the compounds discovered, with significant α-glucosidase inhibitory behavior in vitro that was inconsistent with substance content level.

New research emphasize the importance of identifying metabolite interference in LC–MS targeted metabolomics analysis to ensure accurate results. The study highlights the need for thorough investigation and resolution of metabolite interferences for reliable metabolite measurement in targeted metabolomics.