Mass Spectrometry

FDA scientists have expanded the number of analytes in their analytical method for per- and polyfluoroalkyl substances (PFAS), partly in response to updated guidance out of the European Union (EU) on method parameters and limits of quantification (LOQs).

Researchers in Tianjin, China, have employed all ion unfolding–ion mobility–mass spectrometry (AIU–IM–MS) to enhance the differentiation of therapeutic polyclonal antibodies, offering insights into improvements in conformational stability and advantages in cost-effectiveness.

Valérie Pichon's review in Analytical and Bioanalytical Chemistry delves into sophisticated liquid chromatography techniques for detecting albumin adducts, vital biomarkers in retrospective mustard agent exposure monitoring, offering a broader window of detection than urine-based methods.

A comprehensive analytical approach utilizing online two-dimensional liquid chromatography coupled with hybrid linear ion trap orbital trap mass spectrometry, has enabled the in-depth analysis of Huangqi Guizhi Wuwu decoction, identifying 170 chemical constituents and offering insights into its complex chemical composition and potential therapeutic properties.

A molecular dynamics trajectory approach was shown by a research team to improve ion mobility predictions with deviations of mere percentage points from experimental values.

A research team from India recently explored how GC–MS can help target the metabolic profile of IM-resistant chronic myeloid leukemia (CML) cells.

At HPLC 2023, John Langley, a professor at the University of Southampton in Southampton, UK, presented a talk called "(R)evolution of Hyphenations, Through Open-Access RP-HPLC–MS, Open-Access UHPSFC–MS and 2D-LC–IMS-MS in Academia". He spoke with LCGC on the importance of open-access hyphenation, and how to implement it in your research.

The benefits and challenges of using hydrogen in the laboratory, specifically regarding GC and GC–MS procedures, are discussed.

Researchers from the University of Poitiers and CNES have developed a groundbreaking gas chromatography method, detailed in the journal Chemosensors, which enables the detection of amino acid-like compounds on Mars, offering a vital tool in the quest for extraterrestrial life.

Scientists from the University of Utah in Salt Lake City, Utah, created a new technique to characterize lipids, specifically glycolipids, using ion mobility spectrometry–mass spectrometry (IMS-MS).

Untargeted analysis using liquid chromatography with tandem mass spectrometry (LC–MS/MS) chemical profiling is a valuable tool, but care needs to be taken with experimental design.

Scientists used supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC)—both coupled with high-resolution mass spectrometry (HRMS)—to analyze various types of chlorinated paraffins (CPs) in fish oil-based dietary supplements.

How can low-resolution mass spectrometry (LRMS) and high-resolution (HR) MS work together to provide unambiguous results in clinical and forensic toxicology?

The author discusses the benefits and challenges of using hydrogen in the laboratory, specifically regarding gas chromatography and GC–MS procedures.

The methodologies demonstrated here open the way to fully compliant at-line monitoring of monoclonal antibody quality attributes.

An overview of GLP regulations and related public standards.

Results from our recent survey on sample preparation techniques uncover trends in the field over the last generation and their impact going forwards.

Alasdair Matheson spoke to Jacob de Boer of Vrije Universiteit Amsterdam about a recent innovative research project investigating per- and polyfluoroalkyl substances (PFAS) in fast food packaging.

Researchers have developed a multitargeted internal calibration method for precise quantification of chronic kidney disease (CKD)-related endogenous metabolites using liquid chromatography–mass spectrometry (LC–MS).

To analyze circulating tumor cells (CTCs) more efficiently in clinical whole blood samples, a team of scientists from Chengdu, China, created their own simplified CTC analysis system.

Webinar Date/Time: Wednesday, October 18th, 2023 12:30 pm BST 7:30 am EDT 13:30 pm CEST Thursday, October 19th, 2023 12:30pm BST | 7:30am EDT | 13:30pm CEST

Alexander Makarov was awarded the honor first introduced by the British Mass Spectrometry Society in 1987.

At the Cannabis Sciences Conference, Zacariah Hildenbrand held a talk which focused on various analytical methods and how they affect the cannabis production process.

Webinar Date/Time: Tue, Oct 24, 2023 11:00 AM EDT

Okadaic acid (OA) is considered a marine toxin with distributed hydroxyl, polycyclic ether, and carboxyl groups, easily accumulated in shellfish and known to cause food poisoning in humans.

Webinar Date/Time: Friday, September 29, 2023 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST

Scientists from the National Institute of Pharmaceutical Education and Research (NIPER) in India used a variety of techniques to characterize erdafitinib and its various products.

Researchers investigated the benefits of the efficient and environmentally friendly approach of direct solid-phase microextraction-mass spectrometry (SPME–MS) for rapid analysis.

Researchers from Corteva Agriscience tested a new approach for separating and quantifying small molecule structure elucidation.

In a recent study, researchers from the University of Wisconsin–Madison introduce a set of isobaric tags called DiLeuC, which are designed to aid quantitative analysis of complex samples.