A Fast and Novel Chromatography-Free Forensics Toxicology Urine Screen With DART-MSMS

This webinar will present a rapid, simple, and mass spectrometry (MS)-based urine screen that vastly improves screening and is amenable to quick response to new drug targets. Learn about direct analysis in real time (DART), an ambient ionization technique, and understand how it is used in conjunction with MS in toxicology screening.

Register Free: https://www.chromatographyonline.com/lcgc/chromatography-free

Event Overview

Conventional toxicology urine screens often employ immunoassay, which are prone to false negatives and positives, cross talk, and a variety of other issues. Additions of new test targets are slow and cannot adequately respond to a fast-moving introduction of new substances in today’s world. This webinar will present a rapid, simple, and mass spectrometry (MS)-based urine screen that vastly improves screening and is amenable to quick response to new drug targets.

• Direct analysis in real time-MSMS (DART-MSMS) is combined with ToxBox® (PinPoint Testing, LLC) to offer a fast and simple solution for a wide-audience urine screening workflow.
• The primary goal is to enhance data quality by combining MS with chromatography-free workflows, resulting in seconds per sample analysis time.
• The secondary goal is to simplify the workflow using high-quality commercial kits to lower the threshold of entry into mass spectrometry.
• During the webcast, the entire process will be demoed from samples to results.

Key Learning Objectives:

• Learn about direct analysis in real time (DART), an ambient ionization technique.
• Understand how DART is used in conjunction with MS in toxicology screening.
• Appreciate the simplicity and universality of using kits to promote wider access to cutting-edge technology by general operators.

Who Should Attend:
All parties interested in simplifying and accelerating toxicology screening in production environments while improving data quality.

Speakers:

Terry Bates, PhD
Applications Specialist
Bruker Applied Mass Spectrometry

Terry Bates earned his PhD under the supervision of Dr Gavin Sacks lab at Cornell University where his work focused on the development of novel extraction geometries and rapid throughput analysis for trace level (ng/kg-mg/kg) analytes in complex matrices using solid-phase mesh-enhanced sorption from headspace-direct analysis in real time-mass spectrometry (SPMESH-DART-MS). Terry has additional experience working with chromatography-based techniques (e.g., SPME-GC-MS, LCMS). Prior to his PhD program, Terry earned his BS in molecular biology from the University of Denver and his MS in analytical chemistry at Cornell University. Most recently, Terry began as an application specialist in the Bruker Applied Mass Spectrometry (BAMS) division developing high-throughput chromatography-free workflows for the forensic toxicology, food and beverage, and environmental monitoring industries.

François Espourteille, PhD
Application Manager
Bruker Applied Mass Spectrometry

François Espourteille brings over 25 years of expertise in LC-MSMS applications. He earned a BS and MS from The College of William and Mary in Virginia and received a PhD from Rutgers University, followed by a post-doctoral position at Rensselaer Polytechnic Institute. He joined Cohesive Technologies of Franklin, MA in the application group and subsequently managed the application group for Aria and Transcend platforms within Thermo Fisher Scientific until 2014. For the following decade, François has focused on clinical/toxicological LC-MSMS assays, high-throughput workflows, and 2D LCMS platforms as a consultant. He joined Bruker Applied Mass Spectrometry (BAMS) in 2021 as the DART-MS and Triple Quadrupole Application Manager.

Register Free: https://www.chromatographyonline.com/lcgc/chromatography-free