New Advancements in Biopharma Protein Characterization Using HRIM
Webinar Date/Time: Friday, September 29, 2023 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
Unlock a new realm of molecular analysis in biopharma as we delve into the MOBIE® platform's unprecedented gas-phase separation capabilities, offering superior insights into isomeric N-glycans, peptide PTMs, and intact proteins. Don't miss this opportunity to discover how the MOBIE platform empowers enhanced structural understanding, increased throughput, and greater reproducibility, revolutionizing biopharmaceuticals and more.
Register Free: https://www.chromatographyonline.com/lcgc_w/biopharma-protein
Event Overview
This seminar will demonstrate the utilization of the MOBIE® platform, a high-resolution ion mobility-mass spectrometry (HRIM-MS) instrument based on structures for lossless ion manipulation (SLIM) technology. The platform provides the highest commercially available IM resolution across the full mass range for a variety of biopharma relevant applications. This technology adds a new dimension of gas-phase separation to molecular analysis and is an orthogonal technique to existing MS workflows, which enables increased throughput, additional structural insights, and higher reproducibility. This webinar will focus on peptide therapeutic relevant applications such as:
- LC-HRIM-MS characterization of released N-Glycans.
- Isomeric/isobaric post-translational modifications (PTMs).
- Intact proteins, including mAbs, using the additional dimension of gas-phase separation.
Key Learning Objectives:
- Receive an overview of SLIM technology and the MOBIE platform.
- Learn the advantages of digital separations on throughput, resolution, and reproducibility.
- Understand the real-world impact of HRIM analysis on biotherapeutic analysis.
Who Should Attend:
- Scientists, lab directors, R&D scientists, QA/QC scientists and directors
Speaker:
Greg Kilby
Distinguished Scientist
MOBILion Systems, Inc
With a distinguished career spanning more than 15 years in biopharmaceutical research, Dr Greg Kilby has emerged as a prominent figure in the realm of molecular analysis and mass spectrometry. Holding a PhD in analytical chemistry, Greg's expertise encompasses the pioneering application and development of cutting-edge ion mobility-mass spectrometry technologies. His transformative work revolves around harnessing these innovative platforms to decipher intricate biomolecular structures, shedding light on the complexities of peptide therapeutics and biopharmaceuticals. As an advocate for scientific advancement, Greg's contributions continue to shape the landscape of biopharmaceutical analysis, consistently pushing the boundaries of knowledge and discovery.
Register Free: https://www.chromatographyonline.com/lcgc_w/biopharma-protein
Study Explores Thin-Film Extraction of Biogenic Amines via HPLC-MS/MS
March 27th 2025Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.
Quantifying Microplastics in Meconium Samples Using Pyrolysis–GC-MS
March 26th 2025Using pyrolysis-gas chromatography and mass spectrometry, scientists from Fudan University and the Putuo District Center for Disease Control and Prevention detected and quantified microplastics in newborn stool samples.
Multi-Step Preparative LC–MS Workflow for Peptide Purification
March 21st 2025This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.
