Mass Spectrometry

Mixed-mode cationic exchange (MCX) sorptive tapes combined with direct infusion mass spectrometry enable selective extraction and rapid analysis of cationic compounds in complex samples, such as opioids in saliva.

Internal energy distributions of five classes of ion sources based on dielectric barrier discharge (DBD) were measured, with results suggesting that one particular type of DBD can minimize fragmentation of ions with labile bonds.

A research team has developed a fast and sensitive method using UHPLC–MS/MS to simultaneously detect the nematicide fluensulfone (FSF) and its two major metabolites in different agricultural soils, providing valuable insights into the environmental behavior of FSF in soil systems.

A simultaneous, single-run analysis was sought for metabolites of the central carbon metabolism pathway, which is closely related to the occurrence and development of most diseases in humans.

New method enables comprehensive analysis of secondary formation markers in ambient organic aerosols, providing valuable insights into atmospheric pollutants using HPLC–ESI-TOF-MS.

The development of a newly-designed Girard's reagent, HBP, as charged isobaric mass tags has enabled selective capture and sensitive detection of aldehyde metabolites. The LC–dNLS-MS/MS screening approach using this reagent has successfully facilitated the discovery of natural aldehydes and their profiling in complex samples.

Researchers have developed an innovative strategy for compound annotation in offline 2D-LC–MS analysis. The approach combines hand-in-hand alignment with targeted molecular networking (TMN) and was successfully applied to analyze the chemical profile of Yupingfeng (YPF), a traditional Chinese medicine prescription, resulting in the identification of 497 compounds and demonstrating its efficiency and scalability in complex sample analysis.

Nails were evaluated for their suitability as non-invasive biomarkers for exposure to antibiotics, even those that are commonly prescribed.

A newly developed UHPLC–MS/MS method allows for the accurate analysis of bioactive compounds, including apigenin, apigenin 7-glucoside, and chlorogenic acid, in goat serum.

In a talk at ASMS 2023, Stephanie Rankin-Turner of the Johns Hopkins Bloomberg School of Public Health detailed how thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS) analyzed the body odor of humans to quantify mosquitos' attraction to them.

At ASMS 2023, Sarah Rogstad of the US Food and Drug Administration reviewed and updated a retrospective analysis originally published in 2016.

Agilent and Metrohm join forces, and Waters Corporation completes acquisition of Wyatt Technology.

Applying headspace-SIFT-MS to untargeted screening of food products and ingredients.

At ASMS 2023, Tabitha Hambidge of LGC presented a novel method for automating the certification of reference materials with the help of double exact matching isotope dilution mass spectrometry (DEM-IDMS).

A new method for monitoring tricyclic antidepressants (TCA) in biological fluids and tissues in real time was proposed for the purposes of improving their effects or determining causes of death.

In a talk at ASMS 2023, Rebecca L. Beres of the University of North Carolina at Chapel Hill focused on two types of analysis methods: liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) and a liquid chromatography, ion mobility spectrometry, and mass spectrometry (LC–IMS-MS) platform.

An oral session recognizing the John B. Fenn Distinguished Contribution in Mass Spectrometry Award winner and the Al Yergey MS Scientist Award winners took place on Monday, June 5th, from 4:45–5:30 pm.

Speaking at ASMS 2023, Sara Schlange of the University of Nebraska-Lincoln discussed a mass spectrometry (MS)-based alternative for matrices problematic in current immunoassays regarding the detection of peanut allergens.

At ASMS 2023, LCGC spoke with Erin Baker of the University of North Carolina at Chapel Hill. This segment previews one of several ASMS interviews that were conducted at the conference.

At ASMS 2023, Bayan Almasri of the University of Lille proposed a combination of techniques for the deciphering of insoluble polyester polymer structure.

Characterizing lipid nanoparticles (LNPs) is a developing delivery modality in biotherapeutic analysis. We address some of the current challenges and opportunities in this field, including an examination of the most common tools used to characterize LNPs.

This study suggests a 2D-LC screening method to evaluate peak purity and ensure specificity in pharmaceutical analysis, thereby promoting the safe production of medicines by detecting active pharmaceutical ingredients (API) and related substances.

The latest developments and challenges of using liquid chromatography (LC) for copolymer analysis are discussed.

Here, we preview the 16 Wednesday evening workshops that will take place from 5:45–7:00 pm at ASMS.

Today from 2:30–4:30 pm, an oral session on non-targeted analysis and emerging environmental contaminants will take place. We preview this session here.

ASMS 2023 is excited to be hosting its annual conference in Houston, Texas. Here is what to expect on Sunday evening.

We offer a sneak peek at some of the award presentations that will be taking place at the ASMS 2023 Conference this week.

ASMS will conclude its conference at the Houston Museum of Natural Science (HMNS) on Thursday June 8th, from 7:00 to 10:00 pm. The HMNS is known for their paleontology display, giving attendees the opportunity to embark on a one-of-a-kind prehistoric journey while socializing with friends and colleagues.

The upcoming 2023 ASMS Conference will feature two concurrent tutorial sessions on Sunday, June 4, from 5:00–5:45 pm, along with a Special Keynote Section from 5:45–6:30 pm that will feature local activists from the Houston community.

A novel system combining hydrogel-modified human umbilical vein endothelial cell membrane chromatography with high-performance liquid chromatography-mass spectrometry revolutionizes the screening and purification of active ingredients in herbal medicines.