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Latest:
Py-GC-MS Investigation of Pyrolysis Behaviours and Decomposition Products of α- and β-2,7,11-Cembratriene-4,6-DiolsThe study of the thermal behaviour and pyrolysis products of these terpenoids could possibly suggest flavour precursors that could be used to provide specific flavours to tobacco.
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Comparing the Chemical Profiles of Plant-Based and Traditional Meats Using GC–MS-Based MetabolomicsUntargeted GC–MS metabolomics with sample derivatization is shown here to be effective for measuring the chemical profiles of traditional and plant-based meat products.
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The Role of mD-LC–MS for Antibody Analysis in the Biopharmaceutical IndustryHow is mD-LC–MS changing the way we evaluate HPLC peaks and assess performance?
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Quantitative Determination of Four Lignans in Phyllanthus niruri L. by HPLCA simple analytical method using high performance liquid chromatography (HPLC) with ultraviolet (UV) detection was developed for the simultaneous determination of four main lignans (niranthin, nirtetralin B, hypophyllanthin, and phyltetralin) in Phyllanthus niruri L. plant samples from Guangxi province.
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Application of Liquid- and Supercritical Fluid Chromatography Coupled with High-Resolution Mass Spectrometry for the Analysis of Short-, Medium-, and Long-Chain Chlorinated Paraffins in Dietary SupplementsScientists used supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC)—both coupled with high-resolution mass spectrometry (HRMS)—to analyze various types of chlorinated paraffins (CPs) in fish oil-based dietary supplements.
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Modifying the Metal Surfaces in HPLC Systems and Columns to Prevent Analyte Adsorption and Other Deleterious EffectsA novel surface modification technology has been developed to reduce interactions between analytes and metal surfaces in HPLC instruments and columns. We demonstrate the impact of this technology on peak symmetry, peak area, and injection-to-injection and column-to-column reproducibility for several metal-sensitive analytes.
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Portable and Field‑Deployable Liquid Chromatography for Environmental StudiesLiquid chromatography (LC) is a platform technology amenable to portable and “at-site” or deployable applications. This has awoken end-users to new possibilities and potential cost savings and process improvements.
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Sample Preparation Strategies for Characterizing RNA Modifications in Small-Volume Samples and Single CellsAdvances in sample preparation have enabled analysis of RNA modifications in single cells, paving the way to discovering new insights into the functions of these molecules.
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Trends in Biopharmaceutical Analysis: A Focus on Integrating Single-Cell Omics with Microfluidic ChipsBiopharmaceutical analysis is a rapidly evolving field that requires the development of new technologies and methods to keep pace with the increasing complexity of biologics. One of the most promising areas of research is the use of single-cell omics and microfluidic chips for the analysis of biopharmaceuticals. Single-cell omics has revolutionized our understanding of cellular heterogeneity, while microfluidic chips have enabled high-throughput analysis of single cells that provide an understanding of the complex biological network that complements the genomics and transcriptomics studies. This article will explore some of the emerging trends and technologies in biopharmaceutical analysis, with a particular focus on single-cell omics and microfluidic chips. We will also discuss the developments in ambient ionization mass spectrometry such as sub nanoampere ionization and the potential of low current ionization in studying cell-to-cell heterogeneity and its role in metabolomics.
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Innovation in Nutrition and Food Analysis: The FoodOmicsGR_Research InfrastructureFoodOmicsGR_RI aims to characterize unique Greek products and highlight their value and quality using cutting-edge omics technology.
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Moving Toward Green and Sustainable Sample PreparationMicroextraction techniques have evolved since their appearance three decades ago, moving toward the use of greener and sustainable materials and solvents.
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Novel GC–MS Software Programs for Analyzing Seized Drug SamplesThe role of software to identify and distinguish seized drug samples.
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Rapid Rinse and Shoot: A Screening Workflow for Pesticides in Fruit by GC–MS in Under Six Minutes Using Library Searching of Deconvoluted SpectraTrace-level pesticides and environmental pollutants in the food supply continue to be a worldwide concern. Here we present a fast-screening workflow for residual pesticides present on the surface of fruits using a GC–MS system with direct heating technology and MS spectral deconvolution.
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A Quick Approach to Screen Oligomers from Extractables Studies Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry (LC–QTOF-MS)Analysis of extractables and leachables (E&L) from plastic packaging is of great importance for pharmaceutical product safety. Accurate and rapid identification of unknown compounds in E&L is often complex and challenging. To address this challenge, we demonstrate a quick method for oligomer determination using LC–QTOF-MS.
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Per- and Polyfluoroalkyl Substances (PFAS) or Interference? Using High-Resolution Mass Spectrometry as an Investigative Tool in Food AnalysisMatrix interferences can impact routine analysis with triple quadrupole methods for monitoring and quantifying PFAS in food.
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Turning Metabolomics Data Processing from a “Black Box” to a “White Box”Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.
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Exploring Capillary Electrophoresis–Mass Spectrometry for the In-Depth Intact Native Analysis of Cysteine-Conjugated Antibody-Drug ConjugatesThis article explores the potential of microchip capillary electrophoresis–mass spectrometry (CE–MS) for the characterization of intact biopharmaceuticals, and how this technique can effectively be employed to monitor essential quality attributes of interest.
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The Importance of Complete Overlapping of Analyte and Internal Standard Peaks in Eliminating Matrix Effects with Liquid Chromatography–Mass Spectrometry (LC–MS)Ensuring complete overlapping (coelution) of analyte and internal standard peaks can be critical for eliminating matrix effects in LC–MS/MS analysis.
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Polymer REACH: Pray or be Prepared? A Polymer Chromatography Viewpoint on What to ExpectTimo F. Beskers previews his tutorial lecture at HPLC 2023 in Düsseldorf, where he will give an overview on polymer REACH, its expected regulatory requirements, challenges, and analytical needs, as well as strategies to deal with those from the perspective of polymer chromatography.
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Multivariate Optimization Procedure for Dynamic Headspace Extractions Coupled to GC(×GC)A generalized approach using DoE is presented for the optimization of DHS extraction parameters.
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The Role of mD-LC–MS for Antibody Analysis in the Biopharmaceutical IndustryHow is mD-LC–MS changing the way we evaluate HPLC peaks and assess performance?
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Not (Only) Reversed-Phase Liquid Chromatography–Mass Spectrometry: Alternative LC–MS ApproachesReversed-phase LC–MS has limitations in numerous analytical applications. Alternative MS-compatible chromatographic techniques separate analytes in the liquid phase based on different retention mechanisms compared with reversed-phase LC. This article describes these alternative chromatographic approaches, relevant applications, and the future of these techniques.
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The 3rd Advances in Separation Science Workshop: From Extraction to Chromatographic ApplicationsFrom June 12–13, 2025, the 3rd Advances in Separation Science Workshop will take take place in Gembloux, Belgium.
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Analyze Charge Variants in Antibody-Based Therapeutics Using Cation Exchange ChromatographyThis application note discusses the latest development on high performance cation exchange bio-separation columns for determining charge variants in protein-based biotherapeutics, as well as the strategy on method development.
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Analytical Chemistry: There is No Green Like More GreenAn examination of how greening analytical methods is directly connected to greening the sample preparation step
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Extending the Reach: Non-Proximate Sampling for Mass Spectrometry Analysis of Large Objects and SurfacesNon-proximate MS presents challenges for ion transmission and preventing loss of analyte signal. For continuous, direct MS analysis, there are four models for non-proximate MS that work best.
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A Full Scan Data Review Tool to Match the Speed of Acoustic Ejection Mass SpectrometryAcoustic ejection mass spectrometry (AEMS) has recently emerged as the premier ultrahigh-throughput mass spectrometric methodology for drug discovery and related fields.
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Anomalous Retention Prediction Using Modelling Software in Gradient Reversed-Phase Liquid Chromatography: Why it Can Occur and How to Prevent ItThe success of screening column and mobile phase combinations that generate dissimilar selectivity is highlighted in a typical method development strategy.
