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Empower

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Empower Your Business with the Empower Data Science Link

***Live: Wednesday, March 31, 2021 at 10am EDT | 3pm BST | 4pm CEST*** Learn how Empower Data Science Link enables your digital transformation via our new cloud-based data platform approach to standardize your data, harmonize it , and make it actionable - to improve the overall chromatographic workflows across your organization. Improve productivity, compliance and overall efficiency in your lab with Empower Data Science Link powered by TetraScience. ***On demand available after final airing until Mar. 31, 2022***


Laura Maxon

Latest:

Six Key Differentiators Between Liquid Chromatography and High-Resolution Ion Mobility

Using ion mobility, analytes that have the same molecular mass can be separated by their shape, centers of mass, and collision cross section, but challenges such as ion loss can still occur. A new development in ion mobility separation, high-resolution ion mobility (HRIM), addresses such problems, and is particularly well suited to challenging applications, such as glycosylation monitoring of biological drugs and vitamin D analysis.


LiuLin Deng

Latest:

Effectiveness of High-Resolution Ion Mobility for Complex Analyses

HRIM has emerged as a robust separation strategy for complex chemical analyses due to its ability to improve peak capacity and aid in the separation of isobaric signals.


Lucy Woods

Latest:

Accelerating the Understanding of Metabolomics in Disease Through Improved Sensitivity

By using MS-based techniques, thousands of metabolites can be measured.


Clinton R. Corman

Latest:

Evaluation of PGC Stationary Phases Under High-Temperature LC Conditions for the Analysis of Parabens in Food Samples

This article highlights an advantage of porous graphitic carbon columns, that is their resistance at high temperatures, for the analysis of parabens in foodstuffs.


Hui Li

Latest:

Determination of Fipronil and Its Metabolites in Eggs and Environmental Matrices by LC–MS/MS

An improved LC–MS/MS method that can rapidly detect fipronil, an insecticide harmful to human health, is presented here for chicken eggs, feed, and soil.


Lorenza Schettino

Latest:

Moving Toward Green and Sustainable Sample Preparation

Microextraction techniques have evolved since their appearance three decades ago, moving toward the use of greener and sustainable materials and solvents.


Benjamin P. Libert

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Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography Instrumentation

A recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.


Trevor Kempen

Latest:

Retention Factor is Independent of Pressure in Liquid Chromatography, Right?

Understanding when the effect is likely to be large enough to affect resolution is valuable for troubleshooting unexpected results that arise during both method development and the execution of established methods.


Daniel Meston

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ChromSoc Announces 2023 Martin and Jubilee Awards at HPLC 2023

Tony Edge, President of the Chromatographic Society (ChromSoc), announced the winners of both the 2023 Martin and the Silver Jubilee Awards as Professor Janusz Pawliszyn (University of Waterloo, Canada) and Jared Anderson (Iowa State University, USA), respectively.


Benny Neumark

Latest:

Gas Chromatography–Mass Spectrometry (GC–MS) with Cold Electron Ionization (EI): Bridging the Gap Between GC–MS and LC–MS

Gas chromatography–mass spectrometry (GC–MS) with cold electron ionization (EI) is based on interfacing the GC and MS instruments with supersonic molecular beams (SMB) along with electron ionization of vibrationally cold sample compounds in SMB in a fly-through ion source (hence the name cold EI). GC–MS with cold EI improves all the central performance aspects of GC–MS. These aspects include enhanced molecular ions, improved sample identification, an extended range of compounds amenable for analysis, uniform response to all analytes, faster analysis, greater selectivity, and lower detection limits. In GC–MS with cold EI, the GC elution temperatures can be significantly lowered by reducing the column length and increasing the carrier gas flow rate. Furthermore, the injector temperature can be reduced using a high column flow rate, and sample degradation at the cold EI fly-through ion source is eliminated. Thus, a greater range of thermally labile and low volatility compounds can be analyzed. The extension of the range of compounds and applications amenable for analysis is the most important benefit of cold EI that bridges the gap with LC–MS. Several examples of GC–MS with cold EI applications are discussed including cannabinoids analysis, synthetic organic compounds analysis, and lipids in blood analysis for medical diagnostics.


Duobin Mao

Latest:

Py-GC-MS Investigation of Pyrolysis Behaviours and Decomposition Products of α- and β-2,7,11-Cembratriene-4,6-Diols

The study of the thermal behaviour and pyrolysis products of these terpenoids could possibly suggest flavour precursors that could be used to provide specific flavours to tobacco.


Carl Pieper

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Comparing the Chemical Profiles of Plant-Based and Traditional Meats Using GC–MS-Based Metabolomics

Untargeted GC–MS metabolomics with sample derivatization is shown here to be effective for measuring the chemical profiles of traditional and plant-based meat products.


Jianzeng Xin

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Quantitative Determination of Four Lignans in Phyllanthus niruri L. by HPLC

A simple analytical method using high performance liquid chromatography (HPLC) with ultraviolet (UV) detection was developed for the simultaneous determination of four main lignans (niranthin, nirtetralin B, hypophyllanthin, and phyltetralin) in Phyllanthus niruri L. plant samples from Guangxi province.



Jana Hajslova

Latest:

Application of Liquid- and Supercritical Fluid Chromatography Coupled with High-Resolution Mass Spectrometry for the Analysis of Short-, Medium-, and Long-Chain Chlorinated Paraffins in Dietary Supplements

Scientists used supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC)—both coupled with high-resolution mass spectrometry (HRMS)—to analyze various types of chlorinated paraffins (CPs) in fish oil-based dietary supplements.


Bonnie A. Alden

Latest:

Modifying the Metal Surfaces in HPLC Systems and Columns to Prevent Analyte Adsorption and Other Deleterious Effects

A novel surface modification technology has been developed to reduce interactions between analytes and metal surfaces in HPLC instruments and columns. We demonstrate the impact of this technology on peak symmetry, peak area, and injection-to-injection and column-to-column reproducibility for several metal-sensitive analytes.


Stephen Cahoon

Latest:

Portable and Field‑Deployable Liquid Chromatography for Environmental Studies

Liquid chromatography (LC) is a platform technology amenable to portable and “at-site” or deployable applications. This has awoken end-users to new possibilities and potential cost savings and process improvements.


Kevin D. Clark

Latest:

Sample Preparation Strategies for Characterizing RNA Modifications in Small-Volume Samples and Single Cells

Advances in sample preparation have enabled analysis of RNA modifications in single cells, paving the way to discovering new insights into the functions of these molecules.


Jahziel Chase

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Trends in Biopharmaceutical Analysis: A Focus on Integrating Single-Cell Omics with Microfluidic Chips

Biopharmaceutical analysis is a rapidly evolving field that requires the development of new technologies and methods to keep pace with the increasing complexity of biologics. One of the most promising areas of research is the use of single-cell omics and microfluidic chips for the analysis of biopharmaceuticals. Single-cell omics has revolutionized our understanding of cellular heterogeneity, while microfluidic chips have enabled high-throughput analysis of single cells that provide an understanding of the complex biological network that complements the genomics and transcriptomics studies. This article will explore some of the emerging trends and technologies in biopharmaceutical analysis, with a particular focus on single-cell omics and microfluidic chips. We will also discuss the developments in ambient ionization mass spectrometry such as sub nanoampere ionization and the potential of low current ionization in studying cell-to-cell heterogeneity and its role in metabolomics.


Artemis Lioupi

Latest:

Innovation in Nutrition and Food Analysis: The FoodOmicsGR_Research Infrastructure

FoodOmicsGR_RI aims to characterize unique Greek products and highlight their value and quality using cutting-edge omics technology.


Cristian Azorín

Latest:

Moving Toward Green and Sustainable Sample Preparation

Microextraction techniques have evolved since their appearance three decades ago, moving toward the use of greener and sustainable materials and solvents.


Francis Diamond

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Novel GC–MS Software Programs for Analyzing Seized Drug Samples

The role of software to identify and distinguish seized drug samples.


Bruce Quimby

Latest:

Rapid Rinse and Shoot: A Screening Workflow for Pesticides in Fruit by GC–MS in Under Six Minutes Using Library Searching of Deconvoluted Spectra

Trace-level pesticides and environmental pollutants in the food supply continue to be a worldwide concern. Here we present a fast-screening workflow for residual pesticides present on the surface of fruits using a GC–MS system with direct heating technology and MS spectral deconvolution.


Owen Perlowski

Latest:

A Quick Approach to Screen Oligomers from Extractables Studies Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry (LC–QTOF-MS)

Analysis of extractables and leachables (E&L) from plastic packaging is of great importance for pharmaceutical product safety. Accurate and rapid identification of unknown compounds in E&L is often complex and challenging. To address this challenge, we demonstrate a quick method for oligomer determination using LC–QTOF-MS.


Elsie Peprah

Latest:

Per- and Polyfluoroalkyl Substances (PFAS) or Interference? Using High-Resolution Mass Spectrometry as an Investigative Tool in Food Analysis

Matrix interferences can impact routine analysis with triple quadrupole methods for monitoring and quantifying PFAS in food.



Tao Huan

Latest:

Turning Metabolomics Data Processing from a “Black Box” to a “White Box”

Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.


Lisa Strasser

Latest:

Exploring Capillary Electrophoresis–Mass Spectrometry for the In-Depth Intact Native Analysis of Cysteine-Conjugated Antibody-Drug Conjugates

This article explores the potential of microchip capillary electrophoresis–mass spectrometry (CE–MS) for the characterization of intact biopharmaceuticals, and how this technique can effectively be employed to monitor essential quality attributes of interest.


L.P. Samaranayake

Latest:

The Importance of Complete Overlapping of Analyte and Internal Standard Peaks in Eliminating Matrix Effects with Liquid Chromatography–Mass Spectrometry (LC–MS)

Ensuring complete overlapping (coelution) of analyte and internal standard peaks can be critical for eliminating matrix effects in LC–MS/MS analysis.