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Determination of Phenylurea in Tap Water and Soft Drink Samples by HPLC–UV and Solid-Phase ExtractionA simple and sensitive high performance liquid chromatography (HPLC) method with ultra-violet (UV) detection has been developed for the analysis of phenylurea herbicides.
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Comparison of Supercritical Fluid Extraction (SFE) and Pressurized Solvent Extraction (PSE) for the Recovery of gamma-Tocopherols in Walnut OilGamma-Tocopherol is the dominant form of Vitamin E in many commonly ingested foods in the human diet, such as plant seeds and nuts. In the past, supplement companies have focused on the health benefits of alpha-tocopherol.
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Improving the Universal Response of Nebulization-Based UHPLC DetectionHigh performance liquid chromatography (HPLC) with light absorbance detection (UV) is limited by the dependence of detector response on the structure of the analyte. Some detection techniques based on nebulization of the mobile phase and formation of Aerosol particles demonstrate an analyte independent response that approaches "universal."
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Evaluation of Achiral Stationary Phases for Gradient Screening with Supercritical Fluid ChromatographyUnlike reversed-phase liquid chromatography, SFC lacks a universal stationary phase. Thus, it is important to re-evaluate the default column screening library used with SFC. In this study, three uncommon achiral SFC columns were investigated and compared to three popular stationary phases.
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Mass Spectrometry in Analytical LipidomicsAn overview on the present state of analytical lipidomics is presented from the perspective of mass spectrometry (MS) and the MS strategies most frequently used in lipidomics are highlighted.
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The Analysis of Chlorinated Dioxins, Difurans, and Polychlorinated Biphenyls in Edible OilsThe dioxin family consists of 210 compounds, of which 17 contain the 2,3,7,8 pattern of chlorination. These 2,3,7,8-containing compounds are of extreme concern to human health because of their high level of toxicity. Approximately, 12 of the 209 polychlorinated biphenyls have also been identified as human toxins. For this reason, the US FDA and EU have established strict regulations for the monitoring of food products for human consumption, in particular edible oils. Manual extractions of oils can be a time-consuming procedure often delaying lab turnaround times. By automating the process with the PowerPrep®, food oil samples can be reliably processed with routine 24 h turnaround times.
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Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from HaystacksIon mobility–mass spectrometry (IM-MS) is outlined as a separations method, several examples of the utility of IM-MS for complex biological measurements are illustrated, and the implications of this approach for systems biology research are discussed.
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New Sample Preparation Products and Accessories for 2024This yearly report on new products introduced in the preceding year, since March 2023, covers sample preparation instrumentation, supplies, and accessories.
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PTR-TOF Mobile Air Quality MonitoringIONICON real-time VOC analyzers are frequently deployed in mobile laboratories, contributing to public safety, tracking air pollution where and when it matters.
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Analytical Tools for Enabling Process Analytical Technology: HPLC and Quantitative Polymerase Chain ReactionHow to use these tools to develop an efficient and robust process
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Characterization of Polymeric Excipients by SEC-IRExcipients are pharmacologically inactive substances used as carrier and release controllers for active drug ingredients. A significant amount (30–80% solid) of polymeric excipients such as hydroxyl propyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxypropyl methyl cellulose acetate succinate (HPMCAS), and povidone are used.
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Practical Tips for Operating UHPLC Instruments and ColumnsThe authors explain modern UHPLC instrument design and outline simple procedures to identify causes of poor column and method performance.
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Chiral Purification with Stacked Injections and Collections Using the Prep 100 SFC MS Directed SystemChiral chromatography has become the preferred tool for enantiomer separations in the early stages of pharmaceutical development for the purpose of accurately identifying single pure enantiomers with pharmacologic, toxicological, and clinical information, as stipulated by the FDA.1
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IC–ICP–MS for Monitoring the Fate of Iodinated X-ray Contrast Media after OzonationThis article shows the potential of IC–ICP–MS for monitoring iodine-containing ionic oxidation by-products that form during ozonation of iodinated X-ray contrast media.
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Practical Tips for Operating UHPLC Instruments and ColumnsThe authors explain modern UHPLC instrument design and outline simple procedures to identify causes of poor column and method performance.
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SFC–GCxGC to Analyse Matrices from Petroleum and CoalSFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.
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Consolidated GC-MS/MS Analysis of OCPs, PAHs, and PCBs in Environmental SamplesAnalysis of OCPs, PAHs and PCBs in environmental samples through a consolidated GC-MS/MS method using the Thermo Scientific™ TRACE™ 1310 GC and the TSQ™ 8000 triple quadrupole GC-MS/MS.
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IC–ICP–MS for Monitoring the Fate of Iodinated X-ray Contrast Media after OzonationThis article shows the potential of IC–ICP–MS for monitoring iodine-containing ionic oxidation by-products that form during ozonation of iodinated X-ray contrast media.
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Ion Chromatography for Small Molecule Determination in Clinical and Pharmaceutical Studies .This article presents possible uses of ion chromatography and related techniques combined with various detection methods for clinical and pharmaceutical analysis of common inorganic and organic anions and cations. An overview of achievements in this area from the past 10 years is presented and the most important trends and development perspectives for ion chromatography are described.
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Haloacetic Acid Analysis Using Two-Dimensional Matrix-Elimination Ion ChromatographyThe disinfectants commonly used to treat public drinking water can react with naturally occurring organic and inorganic matter in the source water to form disinfection byproducts such as haloacetic acids. Here, we describe the use of two-dimensional matrix-elimination ion chromatography (MEIC) for haloacetic acid analysis. This method minimizes the impact of matrix ions.
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Enhancing the Sensitivity of Atmospheric Pressure Ionization Mass Spectrometry Using Flow Modulated Gas ChromatographyThe past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics.
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A Generic Method for Target (Group) Analysis in Edible Oils and Fats: Combined Normal-Phase Liquid Chromatography and Capillary Gas ChromatographyEdible oils and fats are complex mixtures of compounds. This article describes the role of normal-phase liquid chromatography as a generic sample pretreatment tool prior to detailed gas chromatography (GC) analysis.
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Liquid Chromatography of Carbohydrates in Human Food and Animal Feeding StuffsFood for human consumption and animal feedstuffs contain a variety of mono-, di-, oligo-, and polysaccharides with different functions. In this article specific liquid chromatographic (LC) systems (column, mobile phase, and detector), which are used to determine different carbohydrates in food and feed matrices, are described.
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Improving the Universal Response of Nebulization-Based UHPLC DetectionHigh performance liquid chromatography (HPLC) with light absorbance detection (UV) is limited by the dependence of detector response on the structure of the analyte. Some detection techniques based on nebulization of the mobile phase and formation of Aerosol particles demonstrate an analyte independent response that approaches "universal."
Latest:
Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from HaystacksIon mobility–mass spectrometry (IM-MS) is outlined as a separations method, several examples of the utility of IM-MS for complex biological measurements are illustrated, and the implications of this approach for systems biology research are discussed.
Latest:
Harmonization of Experimental Methods Used to Measure the True Hold-Up Volume of Liquid Chromatography ColumnsA harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.
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LC–MS-Compatible Separation of Polar Compounds Using Silica Hydride ColumnsA guide to using HPLC in an iterative form to clarify decision-making during method development
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Comprehensive Two-dimensional Liquid Chromatography (LC×LC): A ReviewIn this review, practical principles and guidelines for designing LCxLC methods are given.
Latest:
Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from HaystacksIon mobility–mass spectrometry (IM-MS) is outlined as a separations method, several examples of the utility of IM-MS for complex biological measurements are illustrated, and the implications of this approach for systems biology research are discussed.
