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The chemistry of samples analyzed using gel permeation chromatography/size-exclusion chromatography/gel filtration chromatography (GPC/SEC/GFC) is very diverse. Different chemistries of stationary phases are required to allow for true size separation. Several types of materials are available, all of which have their advantages and limitations. While silica‑based stationary phases are most common in high performance liquid chromatography (HPLC), for macromolecules polymer-based phases are popular.

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PCDDs, PCDFs, and PCBs are toxic compounds categorized as POPs and are ubiquitous throughout the world. Detecting trace levels of PCDD and PCDF is important to monitor food supplies and to ensure industrial emissions meet regulatory standards. In line with the ongoing innovation in dioxin analysis technology, the US EPA is currently evaluating a new method-APGC–MS/MS-for PCDD and PCDF confirmatory analysis. Joe Romano and Douglas Stevens from Waters Corporation discuss the benefits of this new method.

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PCDDs, PCDFs, and PCBs are toxic compounds categorized as POPs and are ubiquitous throughout the world. Detecting trace levels of PCDD and PCDF is important to monitor food supplies and to ensure industrial emissions meet regulatory standards. In line with the ongoing innovation in dioxin analysis technology, the US EPA is currently evaluating a new method-APGC–MS/MS-for PCDD and PCDF confirmatory analysis. Joe Romano and Douglas Stevens from Waters Corporation discuss the benefits of this new method.

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This article describes possible sources of error that may contribute to significant inaccuracy in peptide assay methods: The fi ltration material (cellulose) used in sample clean up and the vial material (glass and plastic) used in LC analysis. This study is based on ?-endorphin but has relevance for most peptide assays.

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Torion Technologies Inc.

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A simple and sensitive high performance liquid chromatography (HPLC) method with ultra-violet (UV) detection has been developed for the analysis of phenylurea herbicides.

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The fundamental mechanisms of band broadening are usually introduced to students through the van Deemter equation. Dimensional analysis of this equation can give physical meaning to the equation coefficients and enhance our understanding relative to qualitative descriptions. This approach can also guide improvements to future liquid chromatography (LC) column designs.

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A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.

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A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.

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A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.

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A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.

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A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.

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A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.

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Paper-based sorptive phases are promising tools in sample preparation because of their high surface-to-volume ratio, porosity, and versatility. This article discusses the synthesis of paper-based sorptive phases by dip coating. This procedure has allowed a wide variety of phases coated with polymers, nanoparticles, and their combination to be synthesized. This article presents the synthesis, types of coatings, and extraction devices, to highlight the versatility and potential of these materials to the analytical community, particularly for sample preparation.

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This article outlines the relevance of extraction techniques, including exhaustive and non-exhaustive ones, in onsite strategies.

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This article outlines the relevance of extraction techniques, including exhaustive and non-exhaustive ones, in onsite strategies.

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The “State-of-the-Art in Capillary Liquid Chromatography” panel discussion at the 43rd International Symposium on Capillary Chromatography (ISCC 2019) in Fort Worth, Texas, USA, was a thoughtful dialogue on current challenges and potential future directions in the field. The session included a general overview of the current state of the field, key drawbacks preventing widespread use of capillary liquid chromatography (LC) columns, and how these challenges might be overcome. In this article, we highlight some of the common themes that were discussed as part of this panel.

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The return of the in-person HPLC Conference was welcomed by the separation science community. There were a lot of developments to share.

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This information is supplementary to the article “The Effect of Carrier Liquid Composition on the Molecular Properties of Caseinate Solutions Studied by AF4” that was published in the March 2020 issue of LCGC Europe.

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This information is supplementary to the article “The Effect of Carrier Liquid Composition on the Molecular Properties of Caseinate Solutions Studied by AF4” that was published in the March 2020 issue of LCGC Europe.

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In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

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A simple and fast ion-pair chromatography method to detect sodium alkyl sulphates in environmental samples using conductivity detection is described.

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In this article, we examine how tandem and tandem hybrid mass spectrometry has opened up new frontiers already. We go further and examine how lesser-known experiments are breaking new ground, with alternative fragmentation techniques, as well as the addition of extra levels of orthogonality by parallel separations techniques.

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Sulphite is a preservative added to a vast range of foods and beverages to prevent browning or oxidation. Some individuals are sensitive to sulphite additives and may experience a range of allergic reactions. Therefore, both the U.S. Food and Drug Administration (FDA) and European Union (EU) laws require that the presence of sulphites be declared on food labels when the concentration exceeds 10 mg/L. Several analytical methods exist to measure sulphite in food and beverages, however, they suffer from repeatability issues, and can be quite cumbersome to perform. A patent has been filed for an innovative, fast, and accurate ion chromatographic (IC) method based on direct current (DC) mode electrochemical detection. This article explains more.

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An improved method for determining total galactooligosaccharide (GOS) content in food and supplements using high performance anion exchange chromatography with pulsed amperometric detection is described.

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This article describes the importance of magnetic bead and chromatographic media selection for hybrid LBA/LC–MS/MS workflows.

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A demonstration of how to successfully convert from capillary zone electrophoresis to dual-opposite injection capillary zone electrophoresis for routine experiments is outlined.

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SFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.

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A fast, selective, and reproducible high performance liquid chromatography (HPLC) method was developed and validated for the analyses of third-generation cephalosporin antibiotics, namely, ceftriaxone, cefixime, and cefdinir in human plasma. The analysis was carried out on a 150 mm Ã- 4.6 mm, 5.0-µm C18 column. The mobile phase used was 80:20 (v/v) 50 mmM phosphate buffer (pH 5.0)–methanol at a flow rate of 1.0 mL/min with 230-nm UV detection.