Author




Christopher O. McGovern

Latest:

Development of an Ultrasensitive LC–MS-MS Method for Determination of 5-Fluorouracil in Mouse Plasma

5-Fluorouracil (5-FU) is a low-molecular-weight anticancer drug in clinical use for several solid tumors in humans. Currently, the most widely used methodology for 5-FU quantitation is liquid chromatography–tandem mass spectrometry (LC–MS-MS) with either liquid–liquid extraction (LLE), protein precipitation, or a combination of both as sample cleanup procedures.



Taylor Hayward

Latest:

Determination of Sulphur-based Odourants in Commercially Available Natural Gas with Flow Modulated Comprehensive Two-Dimensional Gas Chromatography

Pulsed-flow-modulated comprehensive two-dimensional gas chromatography with flame ionisation detection was used to separate and identify all common sulphur compounds found in natural gas.


Haijing Li

Latest:

Analysis of Four Phthalate Monoesters in Human Urine Using Liquid Chromatography Tandem Mass Spectrometry

A fast, sensitive and accurate quantitative method was developed using HPLC–MS–MS for analysis of phthalate metabolites in urine samples.


Jennifer A. Tripp

Latest:

Single-Compound Isotopic Analysis of Organic Materials in Archaeology

The authors review chromatographic separations of archaeological biomolecules for their analysis using accelerator mass spectrometry or isotope ratio mass spectrometry.


Jianhua Cheng

Latest:

Analysis of Four Phthalate Monoesters in Human Urine Using Liquid Chromatography Tandem Mass Spectrometry

A fast, sensitive and accurate quantitative method was developed using HPLC–MS–MS for analysis of phthalate metabolites in urine samples.



Xianzhong Yan

Latest:

Analysis of Four Phthalate Monoesters in Human Urine Using Liquid Chromatography Tandem Mass Spectrometry

A fast, sensitive and accurate quantitative method was developed using HPLC–MS–MS for analysis of phthalate metabolites in urine samples.


Boon K. Ng

Latest:

Tools for Simulation and Optimization of Separations in Ion Chromatography

Computer-based methods can simulate separations for a wide variety of analytes, columns, and eluents.



Olga Shimelis

Latest:

Analysis of Active Cannabis Compounds in Edible Food Products: Gummy Bears and Brownies

Potency testing in marijuana-infused edibles is a problematic task due to the complexity of the matrices. The concentration of active ingredients in edibles can range from a few ppm to 3.5% (1). In this application, active cannabinoid compounds were extracted from gummy bears (and also brownies, results not shown), followed by HPLC analysis.


Sharon Lupo

Latest:

LC–MS Sensitivity: Practical Strategies to Boost Your Signal and Lower Your Noise

Various strategies to improve LC-MS sensitivity in order to enhance signal-to-noise ratio, and help you realize the hidden potential of this method are discussed.



Katerina Naumoska

Latest:

Variable Retention Times — A Case Study

This troubleshooting study of a problem of retention time variation provides a good example of how to track down the source of a problem and how to speculate on probable cause.


Ana Butler

Latest:

Development of an Ultrasensitive LC–MS-MS Method for Determination of 5-Fluorouracil in Mouse Plasma

5-Fluorouracil (5-FU) is a low-molecular-weight anticancer drug in clinical use for several solid tumors in humans. Currently, the most widely used methodology for 5-FU quantitation is liquid chromatography–tandem mass spectrometry (LC–MS-MS) with either liquid–liquid extraction (LLE), protein precipitation, or a combination of both as sample cleanup procedures.






M.R. Lutz Jr

Latest:

Assay for ppm Levels of Azide in Drug Substances

The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of this impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC. The method is shown to be suitable for the intended purpose on three example test materials. Potential issues for wider applications are discussed.


Venkateswarlu Panchagnula

Latest:

Rapid and Direct Quantitation of Pharmaceutical Drugs from Urine Using MALDI-MS

An application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.


Peter J. Butler

Latest:

Development of an Ultrasensitive LC–MS-MS Method for Determination of 5-Fluorouracil in Mouse Plasma

5-Fluorouracil (5-FU) is a low-molecular-weight anticancer drug in clinical use for several solid tumors in humans. Currently, the most widely used methodology for 5-FU quantitation is liquid chromatography–tandem mass spectrometry (LC–MS-MS) with either liquid–liquid extraction (LLE), protein precipitation, or a combination of both as sample cleanup procedures.


Adam Heuberger

Latest:

Nontargeted Metabolite Profiling in Next-Generation Plant Breeding: A Case Study in Malting Barley

The power of nontargeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley that are predictive of desirable malting quality for brewing applications. The metabolite extraction, detection, and analysis methods are high throughput and reproducible, and therefore, this approach represents a practical addition to the plant breeder’s molecular toolbox.


Matej Orešic

Latest:

Ultrahigh-Performance Liquid Chromatography–Mass Spectrometry in Lipidomics

An analytical method for the global profiling of molecular lipids in biological samples, with particular emphasis on the plasmalogen lipids, is described.



Alicia Cannon

Latest:

Automated Solid-Phase Extraction (SPE) and GC–MS Analysis of Pond Water Samples According to EN16691 for PAHs

Polycyclic aromatic hydrocarbons (PAHs) are found worldwide and are emitted from a number of sources including fossil fuel, coal and shale oil derivatives, coke production, and burning wood for home heating, and generally arise from incomplete combustion. Surface water supplies, such as water in ponds, may be used for recreational purposes or become a drinking water source. Characterization of PAHs and their concentration is of interest in maintaining public health.


Mauro DePra

Latest:

Immunoaffinity Solid-Phase Extraction with HPLC-FLD Detection for the Determination of Aflatoxins B2, B1, G2, and G1 in Ground Hazelnut

Using highly specific immunoaffinity solid-phase extraction to selectively extract and enrich aflatoxins prior to HPLC-FLD analysis, without derivatization, low LOQ values-far below the European regulations-can be achieved even in highly complex and fatty matrices.


Roger Reeve

Latest:

Meeting Review: Latest Advances in the Analysis of Complex Environmental Matrices, 2019

A biennial meeting jointly organized by the Environmental Chemistry Group, Separation Sciences Group, and the Water Science Forum, and discussing the latest advances in the analysis of complex environmental matrices, is now in its eighth year. The most recent iteration of the event occurred on Friday 22 February 2019 in the Science Suite, Royal Society of Chemistry, Burlington House, in London, UK. This meeting review offers an overview of what is happening in the industry.