Author
Latest:
Simultaneous Determination of 17 Residual Monomers in Adhesives by Gas Chromatography–Mass SpectrometryAdhesives often contain toxic materials like residual monomers; here, we demonstrate quantitative analysis of residual monomers in adhesives using GC–MS.
Latest:
Novel Automated Method for Sample Preparation for Peptide MappingThis article explores how automation can enhance laboratory productivity and reduces errors in peptide mapping.
Latest:
An Assessment of Stationary Phase Selectivity in SFCSustainability concerns are renewing interest in SFC, often as a substitute for HPLC. With the broader application of SFC, we need a better understanding of selectivity in SFC, where stationary phase classification is not well established. This study assessed and measured the selectivity differences afforded by three prototype SFC phases.
Latest:
Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography InstrumentationA recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.
Latest:
Dispersive Miniaturized Solid‑Phase Extraction Using the CIM‑81 Metal‑Organic Framework and Gas Chromatography–Mass Spectrometry to Determine Personal Care Products in WatersThe analysis of contaminants found in environmental waters and originating from personal care products using metalorganic frameworks (MOFs) combined with liquid chromatography (LC) is described. This work expands the use of MOFs from gas chromatography to LC and also meets the requirements of green analytical chemistry.
Latest:
Online Solid-Phase Extraction–Gas Chromatography–Flame Ionization Detection System for Monitoring Contaminants at Parts-Per-Trillion Concentrations in Process WatersOnline monitoring of odour and taste components that occur at parts-per-trillion (ppt) levels in industrial process waters requires specialized analytical hardware that is generally not compatible with the harsh environmental conditions in these typical industrial settings. An alternative instrumental method is proposed that uses dynamic extraction in combination with gas chromatography (GC) equipped with a simple flame ionization detector (FID) to achieve these extremely low detection limits.
Latest:
Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography InstrumentationA recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.
Latest:
Analytical Applications of Immobilized Enzyme Reactors (IMERs) Coupled to LC–MS/MS for Bottom- and Middle-Up Characterization of ProteinsFlow-through immobilized-enzyme reactors (IMERs) can streamline protein digestion for bottom- and middle-up LC–MS characterization while providing high accuracy and reproducibility.
Latest:
Wastewater Surveillance of Pharmaceuticals and Genes: Challenges and OpportunitiesSample preparation and analysis of pharmaceuticals in wastewater present unique challenges. Here, we describe those challenges.
Latest:
Analytical Chemistry: There is No Green Like More GreenAn examination of how greening analytical methods is directly connected to greening the sample preparation step
Latest:
Pressure–Enhanced Liquid Chromatography as a Suitable Approach to Improve Selectivity for Large Molecule SeparationsPressure-enhanced liquid chromatography (PE-LC) offers a new approach for improving selectivity for large molecule separations. Examples shown here include short oligonucleotides in ion-pairing reversed-phase (IP-RP) liquid chromatography and larger nucleic acids in ion-exchange (IEX) chromatography.
Latest:
Analytical Advantages of Highly Stable Stationary Phases for Reversed-Phase LCDuring the past five years, many manufacturers of HPLC columns have focused on improving stationary phase stability and reproducibility. In this study, the authors use a variety of test solutes to compare the efficiency, selectivity, and hydrophobic retention mechanisms of five commercially available HPLC columns based silica, alumina, zirconia, and polystyrene cross-linked with divinylbenzene as the support.
Latest:
Control Strategies and Method Development for Nitrosamines in APIs and Drug ProductsWebinar Date/Time: Thu, Nov 7, 2024 9:00 AM PST (12:00 PM EST)
Latest:
An Adventurous Journey Around the Thermodynamics of Liquid ChromatographyThe values determined by van’t Hoff analysis only have practical significance if we analyze the results obtained with well-planned and systematically varied experiments.
Latest:
Prioritizing Purity: How Pure is Pure Enough? (December 2023)When it comes to high-purity inorganic raw materials, the key to analytical success is knowing how to define purity. A variety of factors can impact this definition, including the specific application as well as the chemist’s needs.
Latest:
Versatile technique for validating HPLC methodsA new technical study demonstrates the utility of a non-invasive liquid flowmeter for validating the performance of HPLC systems across a range of 9 different solvents.
Latest:
Polysorbate Analysis in Biopharmaceutical Applications—A Snapshot of the Analytical ToolboxAn overview of different approaches for the qualitative and quantitative analysis of polysorbates.
Latest:
Let’s Get Small: Miniaturizing Separations for Single-Cell AnalysisFurther miniaturization of separations will greatly extend the reach of single-cell proteomics, metabolomics, and lipidomics, but key challenges in instrumentation, column technology, and ionization sources must be addressed.
Latest:
A Rapid, Automated Extraction Platform to Assess Drug Product Potency by Online Liquid Chromatography (LC)A new automated active pharmaceutical ingredient (API) extraction approach with integrated analysis by online liquid chromatography (LC) to assess drug product potency is presented.
Latest:
Investigating Decomposition Odor in a Tropical Climate by Comprehensive Two-Dimensional Gas Chromatography (GC×GC) Coupled with Mass Spectrometry (MS) and Flame Ionization Detection (FID)Decomposing animal tissue releases volatile organic compounds (VOCs), of interest in forensic science. We describe the use of GC×GC–qMS/FID retrofitted with a reverse fill/flush (RFF) flow modulator for analyzing these VOCs in a tropical climate.
Latest:
Separation Science: The State of the Art: Graph Neural Networks for Improved Retention Time PredictionsIn this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.
Latest:
Enhancing Evaporation Efficiency: The Impact of Temperature and Gas Flow on Blowdown EvaporationEvaporation enhances method sensitivity. This study investigates the impact of gas temperature and flow rate on blowdown evaporation of solvents and their mixtures
Latest:
Analysis of UV-Treated Mushrooms: Dietary Source of Vitamin D2?In our study, a fast and sensitive liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) method for the determination of vitamin D2 in fresh mushrooms and its metabolite 25(OH)D2 in the blood of volunteers regularly consuming UV-treated mushrooms has been introduced.
Latest:
Authentication of Panax Ginseng‑Based Herbal Teas Using “Chemical Markers” StrategyThis article describes the method development involved in the authentication of nutraceuticals, particularly those containing Panax ginseng, which is popular because of possible positive effects on human health.
Latest:
A Suitable Therapeutic Drug Monitoring Method for Amoxicillin in Plasma by High Performance Liquid Chromatography–UV (HPLC–UV) in NeonatesThis simple, rapid, and accurate HPLC-UV method can facilitate routine therapeutic drug monitoring in neonates.
Latest:
Using the Empore EZ-Trace SPE Workstation to Perform Efficient and Reproducible Extractions of SVOCsThis application note demonstrates how the Empore EZ-Trace SPE system is used to perform multiple extractions simultaneously while achieving clean and reproducible results using EPA Method 525.3 as an example application.
Latest:
Per- and Polyfluoroalkyl Substances (PFAS) or Interference? Using High-Resolution Mass Spectrometry as an Investigative Tool in Food AnalysisMatrix interferences can impact routine analysis with triple quadrupole methods for monitoring and quantifying PFAS in food.
