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Analysis of UV-Treated Mushrooms: Dietary Source of Vitamin D2?In our study, a fast and sensitive liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) method for the determination of vitamin D2 in fresh mushrooms and its metabolite 25(OH)D2 in the blood of volunteers regularly consuming UV-treated mushrooms has been introduced.
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Authentication of Panax Ginseng‑Based Herbal Teas Using “Chemical Markers” StrategyThis article describes the method development involved in the authentication of nutraceuticals, particularly those containing Panax ginseng, which is popular because of possible positive effects on human health.
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A Suitable Therapeutic Drug Monitoring Method for Amoxicillin in Plasma by High Performance Liquid Chromatography–UV (HPLC–UV) in NeonatesThis simple, rapid, and accurate HPLC-UV method can facilitate routine therapeutic drug monitoring in neonates.
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Using the Empore EZ-Trace SPE Workstation to Perform Efficient and Reproducible Extractions of SVOCsThis application note demonstrates how the Empore EZ-Trace SPE system is used to perform multiple extractions simultaneously while achieving clean and reproducible results using EPA Method 525.3 as an example application.
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Per- and Polyfluoroalkyl Substances (PFAS) or Interference? Using High-Resolution Mass Spectrometry as an Investigative Tool in Food AnalysisMatrix interferences can impact routine analysis with triple quadrupole methods for monitoring and quantifying PFAS in food.
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Liquid Chromatographic Peak Purity Assessments in Forced Degradation Studies: An Industry PerspectiveThis review article discusses scientific rationales and current best practices in the pharmaceutical industry for performing chromatographic peak purity assessments (PPA). These activities are associated with the development and validation of liquid chromatographic (LC) stability-indicating analytical methods applicable to regulatory submissions of small-molecule drug candidates. The discussion includes a comprehensive overview of the PPA-related regulatory and scientific landscape and common industry approaches to obtain PPA results, as well as the strengths and weaknesses of PDA-facilitated ultraviolet (UV) PPA and other PPA techniques.
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Advanced LC–MS Analysis for PFAS Analysis in EggsThe European Commission's regulation on maximum levels for certain contaminants in food highlights the need for precise and reliable methods to quantify per- and polyfluoroalkyl substances (PFAS) in various food matrices. This article discusses development and validation of a robust method for analyzing 21 PFAS compounds in chicken eggs using solid-phase extraction (SPE) and liquid chromatography–mass spectrometry (LC–MS).
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A Hydrophilic Strong Anion-Exchange Hybrid Monolith for Capillary Liquid ChromatographyThis article presents a new hydrophilic SAX hybrid monolithic column prepared by in‑capillary coating 5 μm bare silica particles with functional organic polymers. After preparation conditions were investigated and selected, the resulting column was characterized in detail.
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Innovation in Nutrition and Food Analysis: The FoodOmicsGR_Research InfrastructureFoodOmicsGR_RI aims to characterize unique Greek products and highlight their value and quality using cutting-edge omics technology.
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Polysorbate Analysis in Biopharmaceutical Applications — A Snapshot of the Analytical ToolboxAn overview of different approaches for the qualitative and quantitative analysis of polysorbates.
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Dispersive Miniaturized Solid‑Phase Extraction Using the CIM‑81 Metal‑Organic Framework and Gas Chromatography–Mass Spectrometry to Determine Personal Care Products in WatersThe analysis of contaminants found in environmental waters and originating from personal care products using metalorganic frameworks (MOFs) combined with liquid chromatography (LC) is described. This work expands the use of MOFs from gas chromatography to LC and also meets the requirements of green analytical chemistry.
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Development of a “Freeze-Pour” Sample Preparation Method for the GC Analysis of Semivolatile Flavouring Chemicals Present in E-cigarette Refill LiquidsHS-GC analysis is presented as an excellent method for the analysis of high volatile components in e-liquids. For the analysis of semivolatile ingredients, an additional sample preparation step is proposed based on a LLE followed by a freeze-out of the matrix components.
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Innovation in Nutrition and Food Analysis: The FoodOmicsGR_Research InfrastructureFoodOmicsGR_RI aims to characterize unique Greek products and highlight their value and quality using cutting-edge omics technology.
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The Importance of Analyzing Sulphur Compounds in FoodThe identification and quantification of sulphur are real analytical challenges, demanding selective and sensitive methods. Analysis of products such as beer, wine, coffee, and vegetables are discussed.
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Moving Toward Green and Sustainable Sample PreparationMicroextraction techniques have evolved since their appearance three decades ago, moving toward the use of greener and sustainable materials and solvents.
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Good Laboratory Practice (GLP): An Overview for the Analytical ChemistGLP helps ensure the quality of different studies during drug development. Here, the authors outline practices relevant to analytical and bioanalytical chemists.
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Micro-Pillar Array Column Separations for Proteomics of Liver OrganoidsA micro-pillar array format for mapping the proteome of human stem cell-derived liver organoids using timsTOF–MS is presented.
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SEP21 PreviewThe 14th Congress of the French-speaking Association for Separative Sciences (SEP21) will take place at the Porte de Versailles in Paris, France, from 5–7 October 2021. This preview explores what visitors can look forward to from the conference.
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Separation of All Classes of Carbohydrates by HPAEC-PADHigh performance anion-exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD) is a potential method of choice for the analysis of carbohydrates.
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Simultaneous Determination of 17 Residual Monomers in Adhesives by Gas Chromatography–Mass SpectrometryAdhesives often contain toxic materials like residual monomers; here, we demonstrate quantitative analysis of residual monomers in adhesives using GC–MS.
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Breaking Through LC/MS Barriers: Advancing Cyclic Peptide Characterization in Drug Development With the MOBIE Next-Gen Separations PlatformWebinar Date/Time: Tue, Nov 12, 2024 11:00 AM EST
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Nexera SFC Systems Combine Analysis, Purification & ExtractionAre you working with LC and GC in pharmaceutical discovery, development, or QC/QA? Looking for higher speeds, increased sensitivity, reduced solvent consumption and automated sample prep/collection?
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The LCGC Blog: Whence the Next Generation of Macromolecular Separations Scientists?It is of paramount importance that companies develop their in-house macromolecular separations expertise, not only polymer manufacturing companies but also those employing macromolecules for any of a host of applications, from drug-delivery and tablet coatings to ink-jet printer formulations and food additives, to name but a few.
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Development of a Standardized Protocol for the Classification of Column Sets in Comprehensive Two-Dimensional Gas ChromatographyThe article discusses the classification and characterization of GC×GC column sets based on polarity and orthogonality, introducing a standardized approach using a reference mixture called the Century Mix to evaluate the selectivity and performance of these column sets.
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Comparing the Chemical Profiles of Plant-Based and Traditional Meats Using GC–MS-Based MetabolomicsUntargeted GC–MS metabolomics with sample derivatization is shown here to be effective for measuring the chemical profiles of traditional and plant-based meat products.
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Retaining Talent in Field-Flow Fractionation: An InitiativeThe authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.
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High-Throughput Profiling of Long Chain Fatty Acids and Oxylipins by LC–MSLong chain fatty acids (LCFAs) function as a source of metabolic energy, substrates for membrane biogenesis, and storage of metabolic energy. Oxylipins, oxygenated derivatives of LCFAs, regulate the activity of many cellular processes. Existing methods for the analysis of LCFAs and oxylipins have limited compound coverage and sensitivity that, therefore, prevent their application in biological studies. In this work, we developed a high-throughput LC–MS method for analysis of 51 LCFAs and oxylipins. LCFAs and oxylipins were first extracted from biological samples via solid-phase extraction. The extracted molecules were analyzed by targeted comparative metabolomics. Saturated and monounsaturated LCFAs were analyzed in single ion reaction mode, while polyunsaturated LCFAs and oxylipins were analyzed in multiple reaction monitoring mode. Using this method, we successfully quantified 31 LCFAs and oxylipins from mouse livers.
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Mass Spectrometry–Based Process Analytical Technologies for Cell TherapiesEven compared to other biopharmaceuticals, chimeric antigen receptor (CAR) T-cell therapies are particularly complex. Mass spectrometry (MS)–based process analytical technologies can be a powerful tool in identifying and monitoring key attributes throughout the manufacturing process.
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Lowering Limits of Quantitation in LC–MS/MS Analyses for Food Safety and Environmental ApplicationsHow to lower the limits of quantitation as the regulatory landscape continues to evolve.
