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LC–MS-MS Method for the Determination of Enalapril and Enalaprilat fro Human Plasma Using SOLAA liquid chromatography tandem mass spectrometry method for enalapril and enalaprilat from human plasma has been developed using Thermo Scientific SOLA cartridges. Sample preparation is fast, efficient, and reproducible giving excellent recovery levels for each compound.
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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The Spectro-Electro Array: A Novel Platform for the Measurement of Secondary Metabolites in Botanicals, Supplements, and BeveragesHPLC with diode-array and electrochemical-array detection overcomes sensitivity and specificity limitations in natural products analysis.
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Speeding Up the Analysis of Therapeutic Monoclonal Antibody Fragments Using Supermacroporous Reversed-Phase ParticlesMonoclonal antibody (mAb) treatment is among the most effective method of diagnosis and treatment of a broad range of diseases, including autoimmune disorders, cardiovascular diseases, infectious diseases, cancer, and inflammation. There is an extensive development pipeline for protein and mAb therapeutics, emphasizing the need for innovative and efficient analytical tools that result in faster analysis times. This article explores the use of supermacroporous particles for the analysis of mAbs.
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Rapid and Direct Quantitation of Pharmaceutical Drugs from Urine Using MALDI-MSAn application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.
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Simultaneous Determination of Harpagoside and Its Metabolites in an Aspergillus niger Culture by Solid-Phase Extraction and HPLCA new chromatography-based method for analyzing a traditional Chinese medicine and its metabolites.
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The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
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Analysis of Barbiturates in Urine with Agilent 6430 LC–MS–MS and Poroshell 120 EC-C18Toxicology Laboratory at the Veterans Administration, Portland, Oregon, USA, Agilent Technologies
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Analysis of Pharmaceuticals and Personal Care Products in River Water Samples by UHPLC–TOF-MSA study of pharmaceuticals and personal care products in river water samples is presented from northeastern United States using ultrahigh-pressure liquid chromatography (UHPLC) coupled with TOF-MS for both targeted and nontargeted analytes
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Comprehensive Analysis of Human Plasma Using Gas Chromatography–High Resolution Time-of-Flight Mass Spectrometry: A Workflow to Leverage Electron and Chemical IonizationGas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics. A major challenge in the utilization of GC–EI-MS in metabolomics is the identification of unknowns.
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Field-Flow Fractionation for Biological, Natural, and Synthetic Polymers: Recent Advances and TrendsA review of the latest trends in field-flow fractionation (FFF) for various types of polymer analysis.
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Mass Spectrometry — Sustaining Growth in a Challenging WorldA focused outlook on how laboratory mass spectrometry techniques will fare this year compared to 2012.
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Advances in Microsampling for In Vivo Pharmacokinetic StudiesAdvances in Microsampling for In Vivo Pharmacokinetic Studies in Rodents
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
Latest:
The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
Latest:
An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Trends in Enantioselective High Performance Liquid ChromatographyEnantioselective high performance liquid chromatography (HPLC) is slowly adopting the modern particle technologies (sub-2-µm fully porous particles [FPPs] and sub-3-µm superficially porous silica particles [SPPs]) that have been well known in reversed-phase LC for the past decade. The most significant benefit is that enantiomer separations can be performed much faster, which is of interest in high-throughput screening applications and multidimensional enantioselective HPLC analysis. The state of the art is briefly discussed with some examples documenting the potential of core–shell particle technology and comprehensive multidimensional separations.
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Ultra-High Resolution Chromatography Using 500 mm UHPLC Columns for Detection Of Hidden Sample ComponentsLC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?
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Advances in Supercritical Fluid Chromatography for the Analysis of Chiral and Achiral PharmaceuticalsThis article provides an overview of the most recent advances in the field of chiral and achiral separations in SFC. This involves research focused on the most critical parameters in SFC separations, but also on practical issues such as the serial coupling of columns.
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Field-Flow Fractionation for Biological, Natural, and Synthetic Polymers: Recent Advances and TrendsA review of the latest trends in field-flow fractionation (FFF) for various types of polymer analysis.
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Advances in Sample Preparation: Removing Phospholipids from Biological SamplesAdvances in Sample Preparation: Removing Phospholipids from Biological Samples
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Ionic Liquids and Their Applications in Sample PreparationThis short review covers the use of ionic liquids (ILs) and polymeric ionic liquids (PILs) in solid-phase microextraction (SPME) and dispersive microextraction (DLLME)
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Microwave-Accelerated Extraction — SW-846 Method 3546 and BeyondMicrowave-accelerated extraction (MAE) is described and evaluated. The latest enhancements to this technology are discussed from a hardware and applications perspective.
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Applying Comprehensive Analysis to EPA Method 1613B Samples — Discover Those Compounds Usually Discounted in Environmental SamplesThis article compares results from samples prepared and analyzed according to EPA Method 1613B on a sector instrument with those from a high-resolution, accurate mass TOF mass spectrometer and a low-resolution TOF mass spectrometer interfaced to a comprehensive two-dimensional gas chromatography (GC) system (GC?C–TOF-MS).
