Author

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Low Level PAH Detection with an Extensive Dynamic Range

The analysis of PAHs in less than 16 min using hydrogen as carrier gas and the PerkinElmer? Clarus? SQ 8 GC/MS operating in SIM mode is presented. Detection limits down to 0.5 pg on-column and a wide dynamic range are reported.

Werner Bernhard

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Screening by LC–MS-MS and Fast Chromatography: An Alternative Approach to Traditional Immunoassays?

A new technique was developed based on liquid chromatography coupled with tandem mass spectrometry to analyze drugs that are not part of current immunoassay screening, specifically zolpidem, zopiclone, and zaleplone, or "z-drugs."

B. Monrabal

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Column-based Preparative Fractionation for Polyolefins

Polymer Char

Aaron Kettle

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Recent Advances in Pressurized-Fluid Extraction

Current advances in commercial pressurized-fluid extraction (PFE) instrumentation are discussed, along with the advantages of performing PFE prior to chromatographic analysis.

Martin J. Iedema

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Probing Aqueous Surfaces by TOF-SIMS

A breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.

Sueki Leung

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Effective Cleanup and Analysis of Metronidazole from Foaming Facial Cleanser

When working with complex matrices such as personal care products, sample preparation is perhaps the most difficult step of the analysis process. By utilizing a targeted sample preparation technique, such as ion-exchange SPE, analysis can be significantly improved as compared to less targeted techniques such as liquid-liquid extraction.

Jean-Louis Brix

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Ultratrace Quantitive Analaysis of Catalyst Poisoners Using a Dedicated GC–MS Analyser

A dedicated GC– MS analyser was developed to address the increasing need for more sensitive catalyst poisoner analysis. The system combines the separation power and robustness of a classic backflush configuration with the selectivity and sensisitivitiy of mass spectrometry.

Fei Pang

Latest:

Fast Cap IC Determinations of Inorganic Anions and Cations in Drinking Water

Thermo Scientific Application Note

Ken Meadows

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LC–MS-MS Method for the Determination of Enalapril and Enalaprilat fro Human Plasma Using SOLA

A liquid chromatography tandem mass spectrometry method for enalapril and enalaprilat from human plasma has been developed using Thermo Scientific SOLA cartridges. Sample preparation is fast, efficient, and reproducible giving excellent recovery levels for each compound.

Michael Heidorn

Zhiyong Yang

Latest:

An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human Urine

A sensitive method that reduces the number of false-positive results

P.A. Ullucci

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The Spectro-Electro Array: A Novel Platform for the Measurement of Secondary Metabolites in Botanicals, Supplements, and Beverages

HPLC with diode-array and electrochemical-array detection overcomes sensitivity and specificity limitations in natural products analysis.

James A. Thorn

Ruediger Helling

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Developing a UHPLC Method for UV-based Detection and Quantification of Primary Aromatic Amines in Low Concentrations

Agilent Application Note

Spectra Analysis Instruments, Inc.

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Forensic Drug Identification, Confirmation and Quantification Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

Shanhua Lin

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Speeding Up the Analysis of Therapeutic Monoclonal Antibody Fragments Using Supermacroporous Reversed-Phase Particles

Monoclonal antibody (mAb) treatment is among the most effective method of diagnosis and treatment of a broad range of diseases, including autoimmune disorders, cardiovascular diseases, infectious diseases, cancer, and inflammation. There is an extensive development pipeline for protein and mAb therapeutics, emphasizing the need for innovative and efficient analytical tools that result in faster analysis times. This article explores the use of supermacroporous particles for the analysis of mAbs.

Ajeet Singh

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Rapid and Direct Quantitation of Pharmaceutical Drugs from Urine Using MALDI-MS

An application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.

Jun Chang

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Simultaneous Determination of Harpagoside and Its Metabolites in an Aspergillus niger Culture by Solid-Phase Extraction and HPLC

A new chromatography-based method for analyzing a traditional Chinese medicine and its metabolites.

Hoa K. Chau

Latest:

The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential Viscometry

The need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.

Pat Friel

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Analysis of Barbiturates in Urine with Agilent 6430 LC–MS–MS and Poroshell 120 EC-C18

Toxicology Laboratory at the Veterans Administration, Portland, Oregon, USA, Agilent Technologies

Sergey V. Rakov

Latest:

Analysis of Pharmaceuticals and Personal Care Products in River Water Samples by UHPLC–TOF-MS

A study of pharmaceuticals and personal care products in river water samples is presented from northeastern United States using ultrahigh-pressure liquid chromatography (UHPLC) coupled with TOF-MS for both targeted and nontargeted analytes

Jeff Patrick

Latest:

Comprehensive Analysis of Human Plasma Using Gas Chromatography–High Resolution Time-of-Flight Mass Spectrometry: A Workflow to Leverage Electron and Chemical Ionization

Gas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics. A major challenge in the utilization of GC–EI-MS in metabolomics is the identification of unknowns.

S. Kim Ratanathanawongs Williams