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Green Chemistry Perspectives on Analytical ExtractionsThis article introduces some of the concepts behind green chemistry, covering solvent selection and extraction techniques.
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Detailed Glycosylation Analysis of Therapeutic Enzymes Using Comprehensive 2D-LC–MSIn this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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Separation of Macrocyclic LactonesAvermectins are a series of 16-membered macrocyclic lactone derivatives that are used extensively in animal and crop protection
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Analyzing Per- and Polyfluoroalkyl Substances in Drinking Water Using EPA Methods 533 and 537.1 with Semi-Automated Solid-Phase Extraction (SPE)There is a need for fast and reliable PFAS analyses to monitor drinking water quality. We report on the use of semi-automated sample preparation with EPA methods 533 and 537.1, assessing performance and processing time.
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Advances in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical AnalysisHydrophilic interaction liquid chromatography (HILIC) has recently become more important, particularly for the analysis of polar drugs, metabolites and biologically relevant compounds in glycomics, proteomics, metabolomics and clinical analysis. HILIC makes it possible to increase the retention of polar compounds, achieve orthogonal selectivity and increase mass spectrometry (MS) sensitivity, compared with reversed-phase liquid chromatography. This article discusses the advantages and limitations of HILIC in a variety of practical applications in the pharmaceutical industry.
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The Role of Injection SolventsThe solvent chosen for injection can affect the apearance of chromatographic peaks.
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Ionic Liquids and Their Applications in Sample PreparationThis short review covers the use of ionic liquids (ILs) and polymeric ionic liquids (PILs) in solid-phase microextraction (SPME) and dispersive microextraction (DLLME)
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Characterization of Allergens in Cosmetics by GCXGC–TOF–MS with Variable-Energy Electron IonizationThe detection and quantitation of allergens in complex cosmetics extracts using two-dimensional gas chromatography?time-of-flight mass spectrometry (GC?GC?TOF-MS) is described.
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Significant Improvements in Pesticide Residue Analysis in Food Using the QuEChERS MethodThe analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.
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Intelligent Automation of LC–MS Analysis for the Characterization of Compound LibrariesThis article reports an approach to applying intelligent automation for high-throughput LC}MS analysis of compound libraries using Microsoft Visual Basic software.
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Advantages of HILIC Mobile Phases for LC–ESI–MS–MS Analysis of NeurotransmittersThe aim of this work was to find the optimal conditions to achieve sufficient limits of detection (LOD) that would permit the detection of neurotransmitters by LC–MS–MS in biological samples. An optimized HILIC–ESI–MS–MS system for the analysis of the 12 selected compounds was proposed.
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The LCGC Blog: Molecular Feature Generation for Machine Learning in Analytical MeasurementsIn this LCGC Blog, Kevin Schug discusses the potential machine learning has in helping predict physicochemical properties of molecules and optimizing chemical analysis processes.
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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Improved Resolution of Triazine Herbicides in Drinking Water and WastewaterPhenomenex Application Note
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Semivolatiles Analysis Using Split InjectionAnalyzing a broad range of semivolatile environmental pollutants at low levels requires a sensitive detector as well as an inert sample pathway. While semivolatiles analysis by methods such as EPA 8270 and EPA 625 typically does not require reporting sub nanogram-on-column concentrations, the latest generation of sensitive mass spectrometers and inert GC columns and inlet liners allow analysts to take advantage of the benefits of split injection while maintaining standard method reporting limits.
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Ultra-High Resolution Chromatography Using 500 mm UHPLC Columns for Detection Of Hidden Sample ComponentsLC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Multidimensional LC Approaches for Intact Protein Biopharmaceutical CharacterizationMultidimensional LC can automate sample preparation and provide a convenient way to analyze a sample with complementary columns.
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Simultaneous Determination of Amlodipine and Atorvastatin in Tablet Formulations and Plasma using Capillary ElectrophoresisCapillary electrophoresis (CE) with a UV photo-diode array (DAD) detector was used in a new method to detect the assay of amlodipine besylate (AML) and atorvastatin (ATO) in pharmaceutical formulations and human plasma.
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The Reality Behind Column Insertion DistanceColumn insertion distance is critical to good chromatography. What happens if the column is installed too low in the injection port? Is insertion distance more important when performing split injection or splitless injection? Does the position of the column in the injection port impact reproducibility?
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UCMR 3 Low-Level VOC Analysis by Purge and Trap Concentration and GC-MS Using Selective Ion MonitoringThe United States Environmental Protection Agency (US EPA) has established the Unregulated Contaminant Monitoring Program to collect data for contaminants suspected to be present in drinking water (1). The US EPA is currently proposing Unregulated Contaminant Monitoring Rule 3 (UCMR 3) which will collect data from January 2013 through December 2015. Because of the impact on public health and safety, it is vital to have a system that can detect and analyze for these compounds at low levels.
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Lenses or No Lenses? A Study of Ion Transfer Efficiency at Interfaces in a Lens-Free Triple Quadrupole MSThe efficiency of ion transfer between the quadrupole mass analyzers and the Q2 collision cell in a triple quadrupole mass spectrometry (MS) is critical for instrument robustness and sensitivity. Q2 is a radio frequency (RF) only non-mass filtering quadrupole containing only an inert collision gas such as Ar, He, or N2 to provide collision induced dissociation of the precursor ion selected in Q1.
Latest:
An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
