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Retention and Selectivity of Aromatic Hydrocarbons with Polar Groups in Ternary Reversed-Phase–HPLC Systems with Tetrahydrofuran as ModifierThe variation in selectivity of aromatic hydrocarbons with bisubstituted polar groups is investigated in systems consisting of C18 stationary phase and ternary eluents. The solutions of the ternary eluents were obtained by mixing binary solvents (organic modifier + water) of similar eluent strength. Acetonitrile, methanol and tetrahydrofuran were the organic modifiers applied. The influence of the organic solvent type and its concentration in the ternary mobile phase on retention and selectivity of the solutes is discussed. An approach previously presented by our group was adapted to explain the selectivity changes.
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How to Tackle an Unknown: Notes from the Fourth Method Development Olympics at CoSMoSPut yourself in their spot: How would you tackle analyzing a bag of gummy bears that showed up on your lab bench? Here, we offer some insights from the very capable finalists at The Conference on Small Molecule Science (CoSMoS), which was held in August 2015 in San Diego, California.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Ultratrace Quantitative Analysis of Catalyst Poisoners Using a Dedicated GC-MS AnalyzerCan databases of column characteristics be used to help with HPLC column selection ahead of method development?
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Using GC–MS to Observe Changes in the Essential Oil Concentrations in Cedar Tree (Juniperus virginiana) Leaves During a Drought YearA look at how the concentration of essential oils in cedar leaves is affected by changes in temperature and the amount of rainfall
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Hexavalent Chromium Determination HamiltonAnalysis of chromium species is made challenging due to the nature of the element and diverse sample matrices
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Green Chemistry Perspectives on Analytical ExtractionsThis article introduces some of the concepts behind green chemistry, covering solvent selection and extraction techniques.
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Detailed Glycosylation Analysis of Therapeutic Enzymes Using Comprehensive 2D-LC–MSIn this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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Separation of Macrocyclic LactonesAvermectins are a series of 16-membered macrocyclic lactone derivatives that are used extensively in animal and crop protection
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Analyzing Per- and Polyfluoroalkyl Substances in Drinking Water Using EPA Methods 533 and 537.1 with Semi-Automated Solid-Phase Extraction (SPE)There is a need for fast and reliable PFAS analyses to monitor drinking water quality. We report on the use of semi-automated sample preparation with EPA methods 533 and 537.1, assessing performance and processing time.
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Advances in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical AnalysisHydrophilic interaction liquid chromatography (HILIC) has recently become more important, particularly for the analysis of polar drugs, metabolites and biologically relevant compounds in glycomics, proteomics, metabolomics and clinical analysis. HILIC makes it possible to increase the retention of polar compounds, achieve orthogonal selectivity and increase mass spectrometry (MS) sensitivity, compared with reversed-phase liquid chromatography. This article discusses the advantages and limitations of HILIC in a variety of practical applications in the pharmaceutical industry.
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The Role of Injection SolventsThe solvent chosen for injection can affect the apearance of chromatographic peaks.
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Ionic Liquids and Their Applications in Sample PreparationThis short review covers the use of ionic liquids (ILs) and polymeric ionic liquids (PILs) in solid-phase microextraction (SPME) and dispersive microextraction (DLLME)
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Characterization of Allergens in Cosmetics by GCXGC–TOF–MS with Variable-Energy Electron IonizationThe detection and quantitation of allergens in complex cosmetics extracts using two-dimensional gas chromatography?time-of-flight mass spectrometry (GC?GC?TOF-MS) is described.
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Significant Improvements in Pesticide Residue Analysis in Food Using the QuEChERS MethodThe analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.
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Intelligent Automation of LC–MS Analysis for the Characterization of Compound LibrariesThis article reports an approach to applying intelligent automation for high-throughput LC}MS analysis of compound libraries using Microsoft Visual Basic software.
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Advantages of HILIC Mobile Phases for LC–ESI–MS–MS Analysis of NeurotransmittersThe aim of this work was to find the optimal conditions to achieve sufficient limits of detection (LOD) that would permit the detection of neurotransmitters by LC–MS–MS in biological samples. An optimized HILIC–ESI–MS–MS system for the analysis of the 12 selected compounds was proposed.
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The LCGC Blog: Molecular Feature Generation for Machine Learning in Analytical MeasurementsIn this LCGC Blog, Kevin Schug discusses the potential machine learning has in helping predict physicochemical properties of molecules and optimizing chemical analysis processes.
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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Improved Resolution of Triazine Herbicides in Drinking Water and WastewaterPhenomenex Application Note
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Semivolatiles Analysis Using Split InjectionAnalyzing a broad range of semivolatile environmental pollutants at low levels requires a sensitive detector as well as an inert sample pathway. While semivolatiles analysis by methods such as EPA 8270 and EPA 625 typically does not require reporting sub nanogram-on-column concentrations, the latest generation of sensitive mass spectrometers and inert GC columns and inlet liners allow analysts to take advantage of the benefits of split injection while maintaining standard method reporting limits.
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Ultra-High Resolution Chromatography Using 500 mm UHPLC Columns for Detection Of Hidden Sample ComponentsLC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?
