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Changes in Retention TimeWhat happens when the same method gives different retention times on different instruments?
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Fast Analysis of “Dirty” Samples with Monolithic Silica LC and Silica Gel TLC Stationary PhasesThe development of sample prep, separation, and detection methods for the analysis of food and pharmaceutical samples are described.
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The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
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Evaluating the Temperature Shift in Analytical Temperature Rising Elution FractionationThis article presents a new method to evaluate the temperature shift observed in analytical temperature rising elution fractionation (ATREF). The evaluation is based on the dependence of the measured peak temperature as a function of heating rates. Application of the proposed method does not require any knowledge of the fluid circuit characteristics geometry and avoids the use of narrow preparative TREF standards. The results are found to be more accurate than the method that is usually applied.
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Lean, Green Food-Testing Machines: How Innovations in Microflow LC-MS Can Improve Food Safety Test MethodsThis article describes how a food testing laboratory can transition routine high performance liquid chromatography (HPLC) methods to microflow LC for improved sensitivity, throughput, and robustness of analysis.
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Capillary Electrophoresis-Mass Spectometry for the Analysis of BiopharmaceuticalsAn overview of the important and versatile role that capillary electrophoresis coupled to mass spectrometry plays in the biopharmaceutical analysis.
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Comparison of PFAS Sample Preparation Between WAX + Dispersive GCB and WAX/GCB Cartridges from Water and Soil Extracts Per Draft EPA 1633How to speed up sample prep time and equivalent acccuracy and precision.
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Significant Improvements in Pesticide Residue Analysis in Food Using the QuEChERS MethodThe analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.
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Challenges in the Analytical Characterization of VLPs Through HPLC-Based MethodsThis article discusses the challenges and effective solutions for high performance liquid chromatography (HPLC)-based analytical characterization of virus-like particles (VLPs).
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Blueberry Extracts in Dental HealthExtracts of wild blueberries (Vaccinium angustifolium Ait.) contain bioactive molecules that could be used in the development of new therapeutic treatments for the dental disease periodontitis.
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Ambient Ionization MS Analysis of Swabs Used for Explosives DetectionAn analysis of the capabilities of direct analysis in real time (DART) and desorption electrospray ionization (DESI) sources for the analysis of contaminated fabrics
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Optimizing Flavour Analysis Using Modern Heart-Cutting MDGCThis review discusses recent technological advances in classical heart-cuttting two-dimensional gas chromatography (GC–GC). These developments are then illustrated by application to analysis of important flavour compounds at trace levels in very complex matrices
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Assessing the Suitability of a Green Solvent for GPC and TREF Analyses of PolyethyleneThis study presents results of gel permeation chromatography (GPC) and analytical temperature rising elution fractionation (TREF) of polyethylene in butylal (dibutoxymethane, a halogen-free solvent).
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Rapid and Specific Determination of Contaminants, By-Products, and Additives in Insulating Mineral Oils with Tandem Mass SpectrometryThe use of electrospray ionization–mass spectrometry for rapid and specific determination of the widely used metal deactivators Irgamet-30 and Irgamet-39 is demonstrated here.
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Detailed Glycosylation Analysis of Therapeutic Enzymes Using Comprehensive 2D-LC–MSIn this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.
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Supercritical Fluid Chromatography for Chiral Analysis, Part 2: ApplicationsIn the second part of this review article, the recent progress in SFC for enantiomeric separations is evaluated. Several applications reported on the enantioselective separation of drugs and pharmaceutical compounds using chiral SFC are discussed, including pharmaceutical applications, clinical research, forensic toxicology, and environmental sciences.
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Ambient Ionization MS Analysis of Swabs Used for Explosives DetectionAn analysis of the capabilities of direct analysis in real time (DART) and desorption electrospray ionization (DESI) sources for the analysis of contaminated fabrics
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LC–HRMS Determination of Anticancer Drugs as Occupational Contaminants Applied to Photocatalytic Degradation of Molecules of Different StabilityHere, degradation compounds similar to those formed in metabolic or environmental pathways were generated by adopting a photocatalytic process, quantified in environmental samples by liquid chromatography with multiple-stage mass spectrometry (LC–MSn) analysis using an orbital trap instrument with an electrospray interface, and then identified in indoor environments alongside parent compounds.
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Analysis of Fusarium Toxins Using LC–MS-MS: Application to Various Food and Feed MatricesCo-occurrence of several mycotoxins (deoxynivalenol, zearalenone, T-2-toxin, HT-2 toxin) produced by field fungi, such as Fusarium graminearum and Fusarium culmorum, requires several analysis methods for their characterization. A reliable method for the determination of type A- and B-trichothecenes and zearalenone in cereal-based samples is presented. To achieve optimal mass spectrometric detection, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) were compared. Best results were obtained with ESI by implementing a two-period switching for the ionization polarity. The limit of quantification differs for each individual substance within the range 1–10 ppb. Mean recoveries using a standardized clean-up procedure were in the 54–93% range.
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Simultaneous Determination of Harpagoside and Its Metabolites in an Aspergillus niger Culture by Solid-Phase Extraction and HPLCA new chromatography-based method for analyzing a traditional Chinese medicine and its metabolites.
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The Spectro-Electro Array: A Novel Platform for the Measurement of Secondary Metabolites in Botanicals, Supplements, and BeveragesHPLC with diode-array and electrochemical-array detection overcomes sensitivity and specificity limitations in natural products analysis.
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SweetSep™ ColumnsLatest:
Modern Size-Exclusion Chromatography Separations of Biosimilar Antibodies at Physiological pH and Ionic StrengthThe state of protein-derived self-associated, aggregated, and fragmented impurities in therapeutics are critical quality attributes (CQAs) and are widely monitored using non-denaturing size-exclusion chromatography (SEC).
