Author
Latest:
An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
Latest:
Multidimensional LC Approaches for Intact Protein Biopharmaceutical CharacterizationMultidimensional LC can automate sample preparation and provide a convenient way to analyze a sample with complementary columns.
Latest:
Simultaneous Determination of Amlodipine and Atorvastatin in Tablet Formulations and Plasma using Capillary ElectrophoresisCapillary electrophoresis (CE) with a UV photo-diode array (DAD) detector was used in a new method to detect the assay of amlodipine besylate (AML) and atorvastatin (ATO) in pharmaceutical formulations and human plasma.
Latest:
The Reality Behind Column Insertion DistanceColumn insertion distance is critical to good chromatography. What happens if the column is installed too low in the injection port? Is insertion distance more important when performing split injection or splitless injection? Does the position of the column in the injection port impact reproducibility?
Latest:
UCMR 3 Low-Level VOC Analysis by Purge and Trap Concentration and GC-MS Using Selective Ion MonitoringThe United States Environmental Protection Agency (US EPA) has established the Unregulated Contaminant Monitoring Program to collect data for contaminants suspected to be present in drinking water (1). The US EPA is currently proposing Unregulated Contaminant Monitoring Rule 3 (UCMR 3) which will collect data from January 2013 through December 2015. Because of the impact on public health and safety, it is vital to have a system that can detect and analyze for these compounds at low levels.
Latest:
Lenses or No Lenses? A Study of Ion Transfer Efficiency at Interfaces in a Lens-Free Triple Quadrupole MSThe efficiency of ion transfer between the quadrupole mass analyzers and the Q2 collision cell in a triple quadrupole mass spectrometry (MS) is critical for instrument robustness and sensitivity. Q2 is a radio frequency (RF) only non-mass filtering quadrupole containing only an inert collision gas such as Ar, He, or N2 to provide collision induced dissociation of the precursor ion selected in Q1.
Latest:
An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
Latest:
Changes in Retention TimeWhat happens when the same method gives different retention times on different instruments?
Latest:
Fast Analysis of “Dirty” Samples with Monolithic Silica LC and Silica Gel TLC Stationary PhasesThe development of sample prep, separation, and detection methods for the analysis of food and pharmaceutical samples are described.
Latest:
The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
Latest:
Evaluating the Temperature Shift in Analytical Temperature Rising Elution FractionationThis article presents a new method to evaluate the temperature shift observed in analytical temperature rising elution fractionation (ATREF). The evaluation is based on the dependence of the measured peak temperature as a function of heating rates. Application of the proposed method does not require any knowledge of the fluid circuit characteristics geometry and avoids the use of narrow preparative TREF standards. The results are found to be more accurate than the method that is usually applied.
Latest:
Lean, Green Food-Testing Machines: How Innovations in Microflow LC-MS Can Improve Food Safety Test MethodsThis article describes how a food testing laboratory can transition routine high performance liquid chromatography (HPLC) methods to microflow LC for improved sensitivity, throughput, and robustness of analysis.
Latest:
Capillary Electrophoresis-Mass Spectometry for the Analysis of BiopharmaceuticalsAn overview of the important and versatile role that capillary electrophoresis coupled to mass spectrometry plays in the biopharmaceutical analysis.
Latest:
Comparison of PFAS Sample Preparation Between WAX + Dispersive GCB and WAX/GCB Cartridges from Water and Soil Extracts Per Draft EPA 1633How to speed up sample prep time and equivalent acccuracy and precision.
Latest:
Significant Improvements in Pesticide Residue Analysis in Food Using the QuEChERS MethodThe analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.
Latest:
Challenges in the Analytical Characterization of VLPs Through HPLC-Based MethodsThis article discusses the challenges and effective solutions for high performance liquid chromatography (HPLC)-based analytical characterization of virus-like particles (VLPs).
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
Latest:
Blueberry Extracts in Dental HealthExtracts of wild blueberries (Vaccinium angustifolium Ait.) contain bioactive molecules that could be used in the development of new therapeutic treatments for the dental disease periodontitis.
Latest:
Ambient Ionization MS Analysis of Swabs Used for Explosives DetectionAn analysis of the capabilities of direct analysis in real time (DART) and desorption electrospray ionization (DESI) sources for the analysis of contaminated fabrics
Latest:
Optimizing Flavour Analysis Using Modern Heart-Cutting MDGCThis review discusses recent technological advances in classical heart-cuttting two-dimensional gas chromatography (GC–GC). These developments are then illustrated by application to analysis of important flavour compounds at trace levels in very complex matrices
Latest:
Assessing the Suitability of a Green Solvent for GPC and TREF Analyses of PolyethyleneThis study presents results of gel permeation chromatography (GPC) and analytical temperature rising elution fractionation (TREF) of polyethylene in butylal (dibutoxymethane, a halogen-free solvent).
Latest:
Rapid and Specific Determination of Contaminants, By-Products, and Additives in Insulating Mineral Oils with Tandem Mass SpectrometryThe use of electrospray ionization–mass spectrometry for rapid and specific determination of the widely used metal deactivators Irgamet-30 and Irgamet-39 is demonstrated here.
Latest:
Detailed Glycosylation Analysis of Therapeutic Enzymes Using Comprehensive 2D-LC–MSIn this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.
Latest:
Supercritical Fluid Chromatography for Chiral Analysis, Part 2: ApplicationsIn the second part of this review article, the recent progress in SFC for enantiomeric separations is evaluated. Several applications reported on the enantioselective separation of drugs and pharmaceutical compounds using chiral SFC are discussed, including pharmaceutical applications, clinical research, forensic toxicology, and environmental sciences.
