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The production and sale of counterfeit drugs has risen sharply in recent years. The World Health Organization (WHO) estimates that counterfeit medicines account for approximately 1% of sales in developed countries and well over 10% in developing countries.

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The latest applications for carbon nanotubes in chromatography and sample preparation are outlined.

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The authors present the most common and fundamental techniques that address common matrix issues and discuss the critical chemistry considerations.

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The development of sample prep, separation, and detection methods for the analysis of food and pharmaceutical samples are described.

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Miniaturized separation techniques are advantageous for the analysis of illicit drugs and new psychoactive substances.

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GPC/SEC analysis can be easily optimized to yield improved results when analysing oligomers and low molar mass macromolecules.

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An improved LC–MS/MS method that can rapidly detect fipronil, an insecticide harmful to human health, is presented here for chicken eggs, feed, and soil.

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This article focuses on the progression that chiral stationary phases (CSPs), specifically developed for HPLC, are currently undergoing because of the pressing need of an easy switch to UHPLC.

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The article discusses the application of a hybrid organic/inorganic surface technology that forms a barrier between the sample and the metal surfaces of both the HPLC system and chromatographic column. Formed by a vapor deposition of an ethylene-bridged siloxane polymer on metal substrates), this technology effectively addresses common chromatographic challenges such as analyte loss, carryover, and peak tailing due to metal-analyte interactions. It improves peak symmetry and areas, as well as reproducibility, thereby not only benefiting challenging analytes but also increasing confidence in analytical results. We demonstrate the benefits of this technology through the analysis of B-group vitamins, steviol glycosides, and dextran oligosaccharides typically found in food, beverages, and dietary supplements, showcasing its critical role in improving chromatographic performance.

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This application note demonstrates the use of the Thermo Scientific Syncronis C18 1.7 ?m column for the determination of esomeprazole by UHPLC-UV.

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Advantages of the planar, off-line format of TLC relative to on-line column HPLC, the steps in TLC analyses, and future prospects of TLC are discussed.

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This article describes ways to apply quality-by-design principles to build in a more scientific and risk-based multifactorial strategy in the development of an ultrahigh-pressure liquid chromatography (UHPLC) method for omeprazole and its related impurities.

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Simple, rapid and accurate methods have been developed for the analysis of simple carbohydrates including mono- or disaccharides, or as fairly small glycans (6–11 residues) liberated from glycoproteins using charged aerosol detection combined with mass spectrometry techniques.

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This article discusses what recent advances in gel permeation chromatography/size-exclusion chromatography (GPC/SEC) can deliver in polymer development.

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LC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?

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This proof-of-principle study shows that polymer-based sorptive extraction probes, coupled with secondary focusing by thermal desorption and analysis by flow-modulated GC×GC–TOF-MS/FID, can be used to separate and identify flavour compounds in milk. As well as comparing the profiles of dairy and non-dairy milks, this article highlights the practical benefits of this sampling procedure, the ability of two-dimensional GC to physically separate components that would coelute in one-dimensional GC, and the use of software tools to improve workflow.

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A review article that summarizes the successful sample preparation strategies that have led to some of the highest peptide and protein identification rates reported in the literature

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The need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.

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A carefully chosen analytical technique can enhance the inherent advantages of passive sampling of watercourses over more traditional "grab" or "spot" sampling.

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Microwave-accelerated extraction (MAE) is described and evaluated. The latest enhancements to this technology are discussed from a hardware and applications perspective.

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LCGC NA - The Quantification of Clopidogrel in Human Plasma

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The development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.

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An overview of different approaches for the qualitative and quantitative analysis of polysorbates.

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The variation in selectivity of aromatic hydrocarbons with bisubstituted polar groups is investigated in systems consisting of C18 stationary phase and ternary eluents. The solutions of the ternary eluents were obtained by mixing binary solvents (organic modifier + water) of similar eluent strength. Acetonitrile, methanol and tetrahydrofuran were the organic modifiers applied. The influence of the organic solvent type and its concentration in the ternary mobile phase on retention and selectivity of the solutes is discussed. An approach previously presented by our group was adapted to explain the selectivity changes.