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Identification and Quantification of Different Cannabinoids in Cannabis Sativa (Dec 2022)The presented methods are suitable for the quantification of THC and THCA (and other cannabinoids) in Cannabis sativa and to check THC-free cannabis for compliance.
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Analyzing Synthetic Cathinones Using Direct Sample Analysis Time-of-Flight Mass SpectrometryDirect sample analysis coupled to high-resolution time-of-flight mass spectrometry (TOF-MS) may be effective at analyzing synthetic cathinones, especially for qualitative analysis, because it does not require potentially tedious sample preparation.
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Explaining Silyl Ether Formation (SEF) in Supercritical Fluid Chromatography (SFC)Explaining Silyl Ether Formation (SEF) in Supercritical Fluid Chromatography (SFC)
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Low Phase Ratio Stationary Phase Column Technology for the Characterization of Highly Volatile and Reactive Compounds by Gas-Liquid ChromatographyRecent advances in coating techniques and improved polymers employed as gas chromatographic stationary phases have resulted in commercializing low phase ratio capillary column technology with respectable chromatographic efficiency and inertness.
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Nanomaterials Have Come to Stay: An Overview of their Use as Sorbents in Sample PreparationThis article reviews how nanomaterials are being used in a variety of sample preparation techniques, such as dispersive solid-phase extraction (dSPE), solid-phase microextraction (SPME), stir-bar sorptive extraction (SBSE), and matrix solid-phase dispersion (MSPD).
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The Effect of Draw-Out Lens Diameter on Sensitivity of GC–MS AnalysisGas chromatography–mass spectrometry (GC–MS) allows isolation and identification of individual analytes within a complex mixture. Helium has traditionally been the first-choice carrier gas, owing to its inertness, performance, and relatively cheap price. Since 2001, however, helium has become increasingly expensive with a reported global increase in price of 500% between 2001 and 2016 (1). In 2012–2013, the global helium shortage increased the number of GC users switching to alternative carrier gases and improved the availability of information on their use.
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Ion Chromatography Yesterday and Today: DetectionA look at the current status of detection in ion chromatography, focusing on the most popular detectors in IC: the conductivity detector and the charge detector
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Nontargeted Metabolite Profiling in Next-Generation Plant Breeding: A Case Study in Malting BarleyThe power of nontargeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley that are predictive of desirable malting quality for brewing applications. The metabolite extraction, detection, and analysis methods are high throughput and reproducible, and therefore, this approach represents a practical addition to the plant breeder’s molecular toolbox.
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Ion Chromatography Yesterday and Today: DetectionA look at the current status of detection in ion chromatography, focusing on the most popular detectors in IC: the conductivity detector and the charge detector
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Application of Mass Spectrometry to Support Verification and Characterization of Counterfeit PharmaceuticalsThe production and sale of counterfeit drugs has risen sharply in recent years. The World Health Organization (WHO) estimates that counterfeit medicines account for approximately 1% of sales in developed countries and well over 10% in developing countries.
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Light Scattering for the Masses Monoclonal Antibodies and the Preparative Use of Flow Field-Flow Fractionation (AF4)Proteins - especially monoclonal antibodies (MABs) - have become increasingly important in pharmaceutical work. However, there are some important differences between conventional, chemically-synthesized drugs and proteins. Because of the complex and weak structure of proteins, even a slight change in conditions, such as pH value, temperature, or mechanical stress, may lead to aggregation and a loss of activity or stability.
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The Evolution of Chiral Stationary Phases from HPLC to UHPLCThis article focuses on the progression that chiral stationary phases (CSPs), specifically developed for HPLC, are currently undergoing because of the pressing need of an easy switch to UHPLC.
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EAS Conference Preview of Chromatography Sessions and New FeaturesThe Eastern Analytical Symposium (EAS) will be held this year from November 18 to 20, 2013, in Somerset, New Jersey. EAS is the second largest conference and exposition for laboratory science in the United States dedicated to the needs of analytical chemists and those in the allied sciences.
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Advantages of Hybrid Surface Technology to Improve Chromatographic Analysis of Food, Beverages, and Dietary SupplementsThe article discusses the application of a hybrid organic/inorganic surface technology that forms a barrier between the sample and the metal surfaces of both the HPLC system and chromatographic column. Formed by a vapor deposition of an ethylene-bridged siloxane polymer on metal substrates), this technology effectively addresses common chromatographic challenges such as analyte loss, carryover, and peak tailing due to metal-analyte interactions. It improves peak symmetry and areas, as well as reproducibility, thereby not only benefiting challenging analytes but also increasing confidence in analytical results. We demonstrate the benefits of this technology through the analysis of B-group vitamins, steviol glycosides, and dextran oligosaccharides typically found in food, beverages, and dietary supplements, showcasing its critical role in improving chromatographic performance.
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Helium Supply: The Search For AlternativeThis article provides an update on the search for an alternative to helium.
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Determination of Halogens and Sulphur in Complex MatricesThis article presents a method that combines combustion digestion and ion chromatography into a single analysis (combustion ion chromatography [CIC]) making it possible to detect halogens and sulphur in complex matrices. The method is suitable for use in a wide range of application areas.
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Analysis of Four Phthalate Monoesters in Human Urine Using Liquid Chromatography Tandem Mass SpectrometryA fast, sensitive and accurate quantitative method was developed using HPLC–MS–MS for analysis of phthalate metabolites in urine samples.
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Analysis of Monoclonal Antibodies and Their Fragments by SEC Coupled with HRAM-MSThe biopharmaceutical industry continues to focus on the development of biotherapeutic monoclonal antibody (mAbs) drugs. In this article, the compatibility of SEC coupled with HRAM–MS for the analysis of mAbs is demonstrated.
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Current Practices and Considerations for a Stability-Indicating Method in Pharmaceutical AnalysisWhat are the characteristics and relevant considerations for the development and validation of a stability-indicating method?
