Author
Latest:
Simultaneous Determination of Harpagoside and Its Metabolites in an Aspergillus niger Culture by Solid-Phase Extraction and HPLCA new chromatography-based method for analyzing a traditional Chinese medicine and its metabolites.
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The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
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Analysis of Barbiturates in Urine with Agilent 6430 LC–MS–MS and Poroshell 120 EC-C18Toxicology Laboratory at the Veterans Administration, Portland, Oregon, USA, Agilent Technologies
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Analysis of Pharmaceuticals and Personal Care Products in River Water Samples by UHPLC–TOF-MSA study of pharmaceuticals and personal care products in river water samples is presented from northeastern United States using ultrahigh-pressure liquid chromatography (UHPLC) coupled with TOF-MS for both targeted and nontargeted analytes
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Comprehensive Analysis of Human Plasma Using Gas Chromatography–High Resolution Time-of-Flight Mass Spectrometry: A Workflow to Leverage Electron and Chemical IonizationGas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics. A major challenge in the utilization of GC–EI-MS in metabolomics is the identification of unknowns.
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Field-Flow Fractionation for Biological, Natural, and Synthetic Polymers: Recent Advances and TrendsA review of the latest trends in field-flow fractionation (FFF) for various types of polymer analysis.
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Mass Spectrometry — Sustaining Growth in a Challenging WorldA focused outlook on how laboratory mass spectrometry techniques will fare this year compared to 2012.
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Advances in Microsampling for In Vivo Pharmacokinetic StudiesAdvances in Microsampling for In Vivo Pharmacokinetic Studies in Rodents
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
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An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human UrineA sensitive method that reduces the number of false-positive results
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Trends in Enantioselective High Performance Liquid ChromatographyEnantioselective high performance liquid chromatography (HPLC) is slowly adopting the modern particle technologies (sub-2-µm fully porous particles [FPPs] and sub-3-µm superficially porous silica particles [SPPs]) that have been well known in reversed-phase LC for the past decade. The most significant benefit is that enantiomer separations can be performed much faster, which is of interest in high-throughput screening applications and multidimensional enantioselective HPLC analysis. The state of the art is briefly discussed with some examples documenting the potential of core–shell particle technology and comprehensive multidimensional separations.
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Ultra-High Resolution Chromatography Using 500 mm UHPLC Columns for Detection Of Hidden Sample ComponentsLC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?
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Advances in Supercritical Fluid Chromatography for the Analysis of Chiral and Achiral PharmaceuticalsThis article provides an overview of the most recent advances in the field of chiral and achiral separations in SFC. This involves research focused on the most critical parameters in SFC separations, but also on practical issues such as the serial coupling of columns.
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Field-Flow Fractionation for Biological, Natural, and Synthetic Polymers: Recent Advances and TrendsA review of the latest trends in field-flow fractionation (FFF) for various types of polymer analysis.
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Advances in Sample Preparation: Removing Phospholipids from Biological SamplesAdvances in Sample Preparation: Removing Phospholipids from Biological Samples
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Ionic Liquids and Their Applications in Sample PreparationThis short review covers the use of ionic liquids (ILs) and polymeric ionic liquids (PILs) in solid-phase microextraction (SPME) and dispersive microextraction (DLLME)
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Microwave-Accelerated Extraction — SW-846 Method 3546 and BeyondMicrowave-accelerated extraction (MAE) is described and evaluated. The latest enhancements to this technology are discussed from a hardware and applications perspective.
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Applying Comprehensive Analysis to EPA Method 1613B Samples — Discover Those Compounds Usually Discounted in Environmental SamplesThis article compares results from samples prepared and analyzed according to EPA Method 1613B on a sector instrument with those from a high-resolution, accurate mass TOF mass spectrometer and a low-resolution TOF mass spectrometer interfaced to a comprehensive two-dimensional gas chromatography (GC) system (GC?C–TOF-MS).
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Modernization of the Acetaminophen USP Monograph Gradient HPLC Method for Impurities using USP <621> Guidelines and MaxPeak Premier HPS TechnologyThis application note examines the USP acetaminophen impurities using an HPLC system and UPLC System. Improvements in sample throughput and solvent usage were realized by using newer technology.
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Optimizing Flavour Analysis Using Modern Heart-Cutting MDGCThis review discusses recent technological advances in classical heart-cuttting two-dimensional gas chromatography (GC–GC). These developments are then illustrated by application to analysis of important flavour compounds at trace levels in very complex matrices
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The Characterization of Sugar Beet Pectin using the EcoSEC GPC System Coupled to Multi-Angle Light Scattering, Quasi-Elastic Light Scattering, and Differential ViscometryThe need to increase the use of low valued co-products derived from the processing of sugar beets has prompted the investigation of the structure of the pectin extracted from sugar beet pulp. The characterization of sugar beet pectin is essential as it has the potential to be used in the production of industrial products, e.g., as an emulsifying agent in food systems.
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Cover Story - Technical Challenges Encountered During Chromatographic Method Transfers to Pharmaceutical Manufacturing SitesDrug substance development requires a range of analytical methods to be developed to generate process knowledge and to support in-process and release testing throughout a synthetic sequence. This article describes practical examples of a wide variety of transfer challenges and our remediation strategy.
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Petrochemical ProfilingThe Column spoke to Hans van den Heuvel, the Product Marketing Manager for Bruker Chemical & Applied Markets.
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Sample Preparation for Chromatography: How Much Can Be Automated?The author reviews the automation capabilities available, and some practical considerations to take into account when choosing to automate some or all of the sample preparation and handling steps that must be done before analysis.
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Lenses or No Lenses? A Study of Ion Transfer Efficiency at Interfaces in a Lens-Free Triple Quadrupole MSThe efficiency of ion transfer between the quadrupole mass analyzers and the Q2 collision cell in a triple quadrupole mass spectrometry (MS) is critical for instrument robustness and sensitivity. Q2 is a radio frequency (RF) only non-mass filtering quadrupole containing only an inert collision gas such as Ar, He, or N2 to provide collision induced dissociation of the precursor ion selected in Q1.
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Retention and Selectivity of Aromatic Hydrocarbons with Polar Groups in Ternary Reversed-Phase–HPLC Systems with Tetrahydrofuran as ModifierThe variation in selectivity of aromatic hydrocarbons with bisubstituted polar groups is investigated in systems consisting of C18 stationary phase and ternary eluents. The solutions of the ternary eluents were obtained by mixing binary solvents (organic modifier + water) of similar eluent strength. Acetonitrile, methanol and tetrahydrofuran were the organic modifiers applied. The influence of the organic solvent type and its concentration in the ternary mobile phase on retention and selectivity of the solutes is discussed. An approach previously presented by our group was adapted to explain the selectivity changes.
