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Elevated Temperature HPLC: Principles and Applications to Small Molecules and BiomoleculesThe effects of temperature on HPLC are explored, along with a critical analysis of the effects of temperature change on both peak shape and efficiency.
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An Enhanced Immunoaffinity Enrichment Method for Mass Spectrometry–Based Translational ProteomicsTranslational proteomics has not been as successful as originally anticipated. Because mass spectrometry (MS) can separate proteins at the sequence level, it provides the selectivity needed for this application; however, traditional challenges still exist, including time-to-result, throughput, and sample-size requirements.
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Determination of Phytohormones in Plant Extracts Using In-matrix Ethyl Chloroformate Derivatization and DLLME–GC–MSA fast and simple sample preparation method for the simultaneous determination of 11 phytohormones in plants by GC–MS has been developed.
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Tips & Tricks GPC/SEC: High Temperature GPC versus Ambient GPCGel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard technique to determine the molar mass distribution of synthetic macromolecules. However, some kinds of polymers (for example, polyolefins) are often only soluble in special solvents and require high temperatures to be used during the analysis to keep the sample completely dissolved. Therefore, for the analysis of these polymers, dedicated high temperature GPC systems are used. This article will discuss the pros and cons of both high temperature GPC/SEC and ambient GPC/SEC.
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Morphological Comparison of Silica-Based Monolithic and Particulate Beds by Confocal Laser Scanning MicroscopyThis analysis offers insight for optimizing the structure of monoliths.
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Analyzing Synthetic Cathinones Using Direct Sample Analysis Time-of-Flight Mass SpectrometryDirect sample analysis coupled to high-resolution time-of-flight mass spectrometry (TOF-MS) may be effective at analyzing synthetic cathinones, especially for qualitative analysis, because it does not require potentially tedious sample preparation.
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Advances in TOF-MS-Based Screening for Food Safety Residue Analysis with a Positive ApproachMass spectrometry plays an increasingly significant role in the analysis of residues and contaminants in food. Here we will illustrate how the combination of ultrahigh-pressure liquid chromatography (UHPLC) and high-resolution time-of-flight-mass spectrometry (TOF-MS) is used to generate a screen of veterinary drug residues in products of animal origin. The use of UHPLC–TOF-MS and dedicated, workflow directed software allows rapid screening for large numbers of residues and automated quantification of positive samples. In addition, we illustrate how the data generated using MSE acquisition mode enable critical structural information to be collected, which offers additional selectivity and confirmatory data for compound identification and facilitates elucidation of the structure of newly discovered compounds.
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Disinfection Byproducts in Natural WatersThe occurrence of disinfection byproducts in natural waters poses a health risk for humans as well as aquatic organisms. This article presents a method, which was recently developed at the University of Arizona, in Tucson, Arizona, USA, for the fast and simultaneous determination of 15 regulated and unregulated disinfection byproducts.
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Maximizing the Peak Production Rate in Off-line Comprehensive Two-Dimensional Liquid Chromatography with MS DetectionAn optimization strategy to obtain the best possible performance in the shortest analysis time for comprehensive off-line 2D-LC.
Latest:
Determination of Phytohormones in Plant Extracts Using In-matrix Ethyl Chloroformate Derivatization and DLLME–GC–MSA fast and simple sample preparation method for the simultaneous determination of 11 phytohormones in plants by GC–MS has been developed.
Latest:
Maximizing Robustness and Throughput in Liquid Chromatography by Using Pressure-Controlled OperationAnalysis time can be reduced 10–30% by switching from constant-flow-rate mode to a constant-pressure gradient-elution mode.
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Application of Paper Strip Extraction in Combination with LC–MS-MS in PharmacokineticsRecent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation.
