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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
Latest:
The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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Simultaneous Determination of Methylxanthines and Cotinine in Human Plasma by Solid-Phase Extraction Followed by LC–MS-MSA multiresidue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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Laser Thermal Desorption and GC×GC for Harsh Environment and Planetary Mass SpectrometryThe development of analytical instrumentation for harsh terrestrial environments and outer planet space exploration exponentially increases instrument requirements-for features such as robustness, autonomous operation, and speed-and poses unique system integration challenges. Here, we explore the use of laser thermal desorption coupled to comprehensive two-dimensional gas chromatography (LTD-GC×GC) for use with a compact, high-resolution mass spectrometer for challenging applications.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
Latest:
High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
Latest:
A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
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Determination of α-Amanitin in Human Serum by Solid-Phase Extracton Coupled with HPLC-UVA method is presented for the determination of ?-amanitin, a toxic cyclic octapeptide of amanitin mushrooms, in human serum by solid-phase extraction coupled with high performance liquid chromatography with UV detection.
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Meeting Review: Emerging Separation Technologies 2019Organized by The Chromatographic Society and the Separation Science Group of the Royal Society of Chemistry’s (RSC) analytical division, the Emerging Separation Technologies meeting was held on the 28 March 2019 at the RSC’s central London headquarters in Burlington House.
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Mass Spectrometry of Organic Molecules and Laser-Induced Acoustic Desorption: Applications, Mechanisms, and PerspectivesThis study illustrates the versatility of a laser-induced acoustic desorption (LIAD) approach for volatilization of analytes in modern mass spectrometry.
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Accelerating antibody discovery by monitoring titer and glycosylation with the Octet platformSignificantly reduce time to develop antibodies by combining titer and glycan screening using Bio-Layer Interferometry. Save on FTE costs and perform more projects.
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High-Throughput and High-Efficiency Separations of Antibodies by Reversed-Phase Chromatography Using Organic AlcoholsThe strategies described here can improve the efficiency and analyte recovery of chromatographic methods used to characterize monoclonal antibodies and antibody– drug conjugates.
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The LCGC Blog: Remember the First Time - ChromatographyWhat’s the fastest way to acquire a new chromatographic skill? The answer lies with those who are just beginning to learn.
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Solvent Selection in Countercurrent Chromatography Using Small-Volume Hydrostatic ColumnsHow to use small columns to test potential biphasic liquid systems for use in large-scale countercurrent chromatography separations
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Employing Mechanistic Model’s Flexibility to Create Robust UHPLC Method Design: Case Study on Industrial Cannabis sativa SampleWith the era of new complex drug products there is an increasing demand on multivariate modelling tools to integrate robust analytical method design, facilitate efficient and science-based change management, and improve communication between regulators and industry. Mechanistic models provide several advantages in terms of modelling efficiency, versatility, and high predictive power. The following case study will demonstrate a robust method design for industrial Cannabis sativa.
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Frontiers of Sampling: Design of High Surface Area Thin-Film Samplers for On-site Environmental AnalysisIn on-site environmental applications, representative sampling and proper replication are essential. For these reasons, recent work in thin-film solidphase microextraction has focused on the development of unique holders and customized samplers that are tailored for distinct sampling environments. Here, we explore the latest developments.
Latest:
Frontiers of Sampling: Design of High Surface Area Thin-Film Samplers for On-site Environmental AnalysisIn on-site environmental applications, representative sampling and proper replication are essential. For these reasons, recent work in thin-film solidphase microextraction has focused on the development of unique holders and customized samplers that are tailored for distinct sampling environments. Here, we explore the latest developments.
Latest:
Frontiers of Sampling: Design of High Surface Area Thin-Film Samplers for On-site Environmental AnalysisIn on-site environmental applications, representative sampling and proper replication are essential. For these reasons, recent work in thin-film solidphase microextraction has focused on the development of unique holders and customized samplers that are tailored for distinct sampling environments. Here, we explore the latest developments.
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Fast LC for Conventional HPLC SystemsMany laboratory budgets do not allow the purchase of new ultrahigh-pressure liquid chromatography (UHPLC) systems, and workloads typically are not declining. Fast LC incorporates the use of faster mobile phase flow rates and smaller particles to achieve separations in less time and with equivalent resolution to traditional high performance liquid chromatography (HPLC).
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Macherey-Nagel - Determination of Triphenylmethane Dyes from Aquaculture SamplesThis application note describes the determination of the triphenylmethane dyes Malachite Green and Crystal Violet and their metabolites from the aquaculture samples brown trout, shrimp, and tuna using dispersive SPE (dSPE) with CHROMABOND QuEChERS mixes for sample clean-up.
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Effective Enrichment of Glycopeptides in Drop‑HILIC Approach Using iSPE®-HILIC MaterialDemonstratation of the glycopeptide enrichment efficiency of iSPE®-HILIC material for glycoproteomics applications using a well characterized glycoprotein standard.
