Liquid Chromatography (LC/HPLC)

Nysa Membrane Technologies, Inc., announced Natrix Separations, Inc. as the company's new name.

Ronald E. Majors, a senior chemist at Agilent and LCGC's "Column Watch" and "Sample Preperation Perspectives" columnist, received the Chromatographic Society?s 2007 Martin Gold Medal at HPLC 2008.

Researchers conducting clinical research trials of patients with bladder cancer have discovered a non-invasive way to detect the cancer by using HPLC/MS.

The Pittsburgh Conference announces the launch of its 2009 website, www.pittcon.org, containing relevant information for conferees and exhibitors about Pittcon 2009 which will be in Chicago, Illinois, McCormick Place, March 8 -13, 2009.

Agilent Technologies Inc. (Palo, Alto, California) announced it has acquired substantially all of the assets of Taiwan-based Escort Instruments Corp., an established supplier of low-cost test and measurement instruments and a subsidiary of Unitech Printed Circuit Board Corp.

What do you do when the method can't be reproduced?

Many HPLC analyses could be performed at lower expenditure. This could involve a combination of reducing the analysis time, reducing the resolution between critical peaks, and lowering the consumption of mobile phase. Successfully optimizing the method in such instances - as well as in situations where it is necessary to transfer the method to another laboratory that lacks the same selection of columns - can save the analyst time and money.

This article investigates the different methods that can be used to compare the performance of liquid chromatography (LC) columns to assess the advantage of using them at high pressures and/or high temperatures. The main focus is on the kinetic plot method. This method, which is based on two simple equations, allows the user to transform the more common Van Deemter curve into a curve describing the ultimate separation speed as a function of the required plate number, or the required peak capacity or the required resolution.

John Dolan has discovered that check-value problems have jumped to the top of the list with LC users. He takes a look at them in this month's installment of "LC Troubleshooting."

Guest columnsist and LCGC Emerging Leader award recipient Gert Desmet considers the different methods that can be used to compare the performance of LC columns.

Thermo Fisher Scientific Inc., the world leader in serving science, announced that they have been presented with two 2008 Frost & Sullivan Best Practices awards for Market Leadership and Competitive Strategy Leadership in Informatics.

In the first reported study of skeletal muscles in hibernating creatures by two-dimensional gel electrophoresis (2-DE), scientists from Korea have attempted to shed some light on the molecular processes behind atrophy prevention.

Scientists in China have devised a GC-ECD procedure that involves bromination of acrylamide to give a derivative that is more easily detected at low levels than acrylamide itself. Their research comes in response to the discovery of acrylamide in many types of cooked food in 2002. This discovery made news due to the link between acrylamide and cancer. From a scientific point of view, the acrylamide discovery ensured the creation of a new generation of research grants, many of which involve mass spectrometry, using GC?MS or LC?MS.

Chiral Separations will be the topic of discussion during a mid-day session on Wednesday at HPLC 2008 in Baltimore. Torgny Fornstedt from the University of Uppsala will chair the three-presentation session, which will take place in Harborside Ballroom C.

Good morning, and welcome to this, our final day of coverage from HPLC 2008. The staff of LCGC has had a great week in Baltimore, a city that always makes a great host for a conference - particularly for those of us from just up the road in New Jersey. And of course, the week is far from over, as there is still more to come beyond today, so look for more sessions and tutorials on Thursday and Friday.

As HPLC 2008 comes to a close there are still many valuable sessions to attend. "Glycoprotein Analysis" sounds like an interesting session that will feature talks on "Multimethodological Approaches to Structural Analysis of Glycoproteins in Complex Mixtures," "Capillary and Microcolumn Based Fluidic Platforms for Proteomics/Glycoproteomics," and "Fingerprints of Darbepoetin Alfa in Human Plasma by LC-MS-MS."

Good morning, and welcome to Day 2 of LCGC's daily conference report from HPLC 2008. With the exhibits opening today, we hope you will stop by and see us at Booth #115. We have an assortment of complimentary issues available, including our most recent HPLC-themed supplement, "Current Trends in LC Column Technology," containing the latest research from the most prominent thought leaders in the industry.

Tuesday morning at HPLC 2008 will feature a session on "Advances in Column Technology I" in Harborside Ballroom C. The session, chaired by W. John Lough from the University of Sunderland, includes presentations from an LCGC columnist and an author from a recent supplement ? both of whom were honored on Monday at HPLC 2008.

The second day at HPLC 2008 will feature sessions like "2D HPLC" with LCGC Advisory Board member Peter Schoenmakers as the chair. The first part of the session, "Fast 2D-LC for Chemical Analysis: the Promises and the Challenges" will also feature an LCGC Advisory Board member, Peter Carr.

HPLC 2008 will surely be an exceptional conference with sessions like, "Applications of Retention Mechanisms" which I will be attending this evening.

Good afternoon, and welcome to LCGC's daily conference report from HPLC 2008, taking place at the Marriott Waterfront Hotel in the scenic Inner Harbor of Baltimore, Maryland. Many of you may recall our coverage of Pittcon 2008 just a couple of months ago, when we brought you all of the breaking developments and cutting edge research that was being introduced and discussed in New Orleans.

LC-MS will be the topic of a short, two-presentation session during Monday's festivities at HPLC 2008 in Baltimore.

Advion Biosciences Inc. (Ithaca, New York), a developer of microfluidic sampling technology for mass spectrometry (MS) has bought almost all assets of its production supplier, Washburn Manufacturing Technologies Inc. (Trumansburg, New York) for an undisclosed amount.

Agilent Technologies has announced the presentation of the 2008 Manfred Donike Award for scientific excellence in sports doping testing to the German research scientist Ulrich Flenker, of the Institute of biochemistry, German Sport University, Cologne, Germany.

GE Healthcare recently announced its completion of the acquisition of Whatman, which is a global supplier of filtration technologies and products.

Merck KGaA (Darmstadt, Germany), a privately-held pharmaceutical and specialist chemicals company, has acquired the assets of chromatographic column developer SeQuant AB (Umea, Sweden). "[The aquisition] offers Merck superb opportunities for the future expansion of the chromatography business," said Klaus Bischoff, head of the Performance and Life Science Chemicals division at Merck.

The assessment of accuracy, which involves the estimation of precision and the determination of trueness, refers to the process of evaluating whether the results provided by analytical methods are close to accepted reference values. The different references available in chromatographic analysis and useful guidelines to perform such a comparison are described.

In this instalment of "Column Watch", columnist Ron Majors examines the role of pressure in high performance liquid chromatography (HPLC) from two viewpoints: the impact of the ultrahigh pressures encountered in ultrahigh-pressure liquid chromatography (UHPLC) on chromatographic parameters and increases in column pressure encountered in normal daily use. The latter is of more practical consequence to HPLC users because increased back pressure usually implies that something has gone wrong with the column. Pressure increases as a result of physical and chemical contamination are explored and practical approaches to solve these problems are suggested.

Ion-pair chromatography can be your best friend or your worst enemy.

For this month's discussion, John Dolan shares some of the key resources that he recommends using when you have one of those "How do I?" questions.