Kate Jones

A two-step workflow to extract pure mass spectra from comprehensive two-dimensional liquid chromatography high-resolution mass spectrometry (LC×LC–HRMS) data has been created and tested.

The benefits of nanobubbles in electrospray ionization mass spectrometry have been investigated.

A research group has developed an improved workflow for constructing machine learning (ML) models in oligonucleotide separation.

Nadia Gadi and Allisson Barros de Souza spoke to LCGC International about their investigation into the application of electrochemical advanced oxidation processes (eAOPs) for the efficient removal of pharmaceutical residues in wastewater.

A study has compared solid-phase extraction (SPE) to traditional normal-phase liquid column chromatography (LCC) methods for the analysis of hydrocarbons by gas chromatography–mass spectrometry (GC–MS).

LCGC International spoke to Paul-Albert Schneide and Oskar Munk Kronik about the development and application of a novel two-step workflow—mass filtering (MF) combined with multivariate curve resolution (MCR)—for extracting clean mass spectra from trace-level compounds in LC×LC–HRMS data.

Ardiana Kajtazi discusses her research identifying organic micropollutants in water using liquid chromatography–high-resolution mass spectrometry (LC–HRMS). She highlights the standardized filtration approach her team has developed based on intersection principles, utilizing retention indices from two reversed-phase liquid chromatography (RPLC) columns.

A two-step workflow to extract pure mass spectra from comprehensive two-dimensional liquid chromatography high-resolution mass spectrometry (LC×LC–HRMS) data has been created and tested.

A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.

LCGC International spoke to Amanda Patrick, associate professor at Mississippi State University, about her research exploring mass spectrometry (MS) applications in ionic liquid analysis.

A team from the University of Geneva and Bayer AG present their findings on the on-off retention of oligonucleotides and the feasibility of separating them using very short columns.

Per- and polyfluoroalkyl substances (PFAS) often make headlines as health agencies worldwide work to regulate their use. While most restrictions focus on PFAS in drinking water, the primary exposure pathway, scientists are increasingly investigating alternative routes, such as dermal absorption from cosmetics, sunscreens, and other everyday products.

An investigation into fluoroelastomer watch bands has revealed high levels of perfluorohexanoic acid (PFHxA), a short-chain per- and polyfluoroalkyl substance (PFAS). LCGC International spoke to Professor Graham Peaslee from the University of Notre Dame about his team’s study using liquid chromatography tandem mass spectrometry (LC–MS/MS) and PFHxA's potential for dermal absorption, and the subsequent environmental and health impacts.

“Forever chemicals” per- and polyfluoroalkyl substances (PFAS) have been found in smartwatch and fitness bands and analyzed using liquid chromatography tandem mass spectrometry (LC–MS/MS) and direct total oxidative precursor (dTOP) assay.

A machine-learning tool to enhance the detection of small organic pollutants in water has been developed and tested.

A method to help detect genotoxic impurities (GTIs) using headspace gas chromatography (HS-GC) and deep eutectic solvents (DESs) has been developed.

Shimadzu Corporation is celebrating 150 years since it was founded with a dedicated website and a collaboratively designed logo.

An LC–HRMS approach for the simultaneous analysis of 15 N-nitrosamines in multiple APIs using a novel HILIC-based SPE clean-up step has been developed and tested.

Waters Corporation has released its 2024 environmental, social, and governance Report detailing its continued sustainability growth.

This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.

Brett Paull has been awarded the Premier’s Tasmanian STEM Researcher of the Year for his outstanding contributions to analytical chemistry.

A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to enhance dicarboxylic acid (DCA) detection and quantification in different biological matrices has been developed and optimized.

The Chromatographic Society (ChromSoc) has announced the winners of the Martin Medal and the Silver Jubilee Medal for 2025. Professor Bogusław Buszewski of Nicolaus Copernicus University in Torun, Poland, has been awarded the prestigious Martin Medal, and the 2025 Silver Jubilee Medal has been awarded to Elia Psillakis of the Technical University of Crete in Greece.

Three analytical and two pre-treatment methods—gas chromatography–mass spectrometry (GC–MS), gas chromatography–tandem mass spectrometry (GC–MS/MS), and liquid chromatography–tandem mass spectrometry (LC–MS/MS) plus liquid-liquid extraction (LLE) and dried blood spot (DBS) —were compared for the quantitation and characterization of barbiturates.

The volatile organic compounds (VOCs) that make up the flavor profile of cigars are examined using gas chromatography (GC) and E-nose.

This month we interview Shijia Tang, principal scientist at Genentech, South San Francisco, CA, USA, about her innovative research focusing on the analysis of polymers and nanomaterials used in pharmaceutical analysis. Shijia decribes the benefits of an innovative in-line mixing modulation method for 2D-LC she developed for polymer and oligonucleotide analysis. The advantages of SEC–MALS to explore aggregation mechanisms for therapeutic constrained peptides and mRNA-lipid nanoparticles and their aggregates are also discussed.

This month we spoke to Zhuoheng Zhou from the Vrije Universiteit Brussel in Belgium about his research on advancing instrumental and column technologies for modern chromatography and its applications in novel biopharmaceutical modalities and proteomics.

LCGC spoke to Leandro Wang Hantao from the University of Campinas in São Paulo, Brazil, about his work investigating the influence of ion management parameters on the data produced by comprehensive gas chromatography–high-resolution mass spectrometry (GC×GC–HRMS) equipped with a fourier transform-orbital ion trap mass analyzer, and his investigation into employing channel occlusion for sample preparation in untargeted analysis in petroleomics.

The Column spoke with Ilaria Belluomo from Imperial College London, UK, about her research in breath analysis. She details her work into a noninvasive breath test that can be used to detect colorectal cancer using GC–MS. She also discusses the use of SIFT-MS for the analysis of VOCs in breath.

This month we interview Zhuoheng Zhou from the Vrije Universiteit Brussel in Belgium, about his focus on advancing instrumental and column technologies for modern chromatography and its applications in novel biopharmaceutical modalities and proteomics. We also spoke to him about his work developing a protocol to help with the design of polymer monolithic capillary columns.