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Determination of the Relative Prevalence of Lurasidone Metabolites in Urine Using Untargeted HRMSFor lurasidone treatment adherence testing, an untargeted high-resolution mass spectrometry method was employed, using known positive human urine samples to identify the lurasidone metabolites and their relative abundance in urine.
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Rapid Determination of 24 Synthetic and Natural Cannabinoids for LC–MS-MS Screening in Natural Products and Drug Inspection ApplicationsMarijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world.
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A Sensitive and Cost-Effective LC–MS-MS Method for Determination of 1α,25-Dihydroxyvitamin D3 in Human PlasmaThe biologically active form of vitamin D is an important analytical target in both research and clinical practice.
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Development of a Fast LC–MS-MS Screen for Common Drugs of Abuse as an Alternative to Immunoassay ScreeningEnzyme immunoassay (EIA) is a conventional drug screening technique, but it can be limited by cross-reactivity that can lead to high false positive rates.
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Rapid Determination of 24 Synthetic and Natural Cannabinoids for LC–MS-MS Screening in Natural Products and Drug Inspection ApplicationsMarijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world.
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An Investigation into the Use of Alternate Carrier Gases for the Determination of Volatile Organic Compounds in Water by GC–MSThis study focuses on United States Environmental Protection Agency (US EPA) Method 524.3 for volatile organic compounds (VOCs) in water using gas chromatography–mass spectrometry (GC–MS).
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The Smell of Success: Using GC–MS–MS for Low Level Allergenic Fragrance DetectionThe regulatory and practical issues that surround allergenic fragrance use within cosmetics and cleaning products are explored in this article.
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Separation of All Classes of Carbohydrates by HPAEC-PADHigh performance anion-exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD) is a potential method of choice for the analysis of carbohydrates.
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Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry for Environmental Analysis of Pharmacologically Active CompoundsThis article gives an up-to-date commentary on chiral liquid chromatography coupled with mass spectrometry for the determination of pharmacologically active chiral compounds (cPACs) (including illicit drugs) in environmental matrices. Several applications are discussed to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.
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Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry for Environmental Analysis of Pharmacologically Active CompoundsThis article gives an up-to-date commentary on chiral liquid chromatography coupled with mass spectrometry for the determination of pharmacologically active chiral compounds (cPACs) (including illicit drugs) in environmental matrices. Several applications are discussed to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.
Latest:
Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry for Environmental Analysis of Pharmacologically Active CompoundsThis article gives an up-to-date commentary on chiral liquid chromatography coupled with mass spectrometry for the determination of pharmacologically active chiral compounds (cPACs) (including illicit drugs) in environmental matrices. Several applications are discussed to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.
Latest:
Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry for Environmental Analysis of Pharmacologically Active CompoundsThis article gives an up-to-date commentary on chiral liquid chromatography coupled with mass spectrometry for the determination of pharmacologically active chiral compounds (cPACs) (including illicit drugs) in environmental matrices. Several applications are discussed to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.
Latest:
Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry for Environmental Analysis of Pharmacologically Active CompoundsThis article gives an up-to-date commentary on chiral liquid chromatography coupled with mass spectrometry for the determination of pharmacologically active chiral compounds (cPACs) (including illicit drugs) in environmental matrices. Several applications are discussed to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.
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AI-Powered Precision for Functional Component Testing in Tea AnalysisAnalyzing functional foods reveals numerous health benefits. These foods are rich in bioactive compounds that go beyond basic nutrition, boosting the immune system and improving overall wellness. However, analyzing these compounds can be challenging. This article discusses AI algorithms to support automated method development for liquid chromatography, simplifying the process, enhancing labor efficiency, and ensuring precise results, making it accessible to non-experts for tea analysis.
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Fast, Sensitive, and Simultaneous Analysis of Multiple Steroids in Human Plasma by UHPLC–MS–MSAccurate steroid measurement is essential for the diagnosis of various disorders, for example in sexual differentiation or gonadal function.
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Explaining Silyl Ether Formation (SEF) in Supercritical Fluid Chromatography (SFC)Explaining Silyl Ether Formation (SEF) in Supercritical Fluid Chromatography (SFC)
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Preparative Chromatography with Improved LoadabilityThe authors show that the loadability and throughput of ionizable compounds can be enhanced by using hybrid packings.
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Why System Suitability Tests Are Not a Substitute for Analytical Instrument Qualification (Part 3): Performance Qualification (PQ)A look at the role of system suitability tests (SSTs) during performance qualification (PQ).
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Nonlinear Predictive Modelling Enables In Silico Optimization of Chromatographic Methods for Complex Stationary Phase‑Analyte InteractionsTo reach satisfactory results in terms of accurate retention time prediction, new in silico optimization approaches must be considered.
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MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
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Unlocking the Power of DataThe modern analytical laboratory generates enormous amounts of data. These data are typically stored in vendor-specific, proprietary file formats
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MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
Latest:
MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
Latest:
MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
Latest:
MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
Latest:
MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
Latest:
MISER LC–MS Analysis of Teas, Soft Drinks, and Energy DrinksIn this study, we describe a simple and rapid liquid chromatography–mass spectrometry (LC–MS) method for the evaluation of caffeine, taurine, and aspartame in teas, soft drinks, and energy drinks using high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI)-MS detection and multiple injections in a single experimental run (MISER) analysis.
