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Analysis of Peptide Mixtures for Proteomics Research Using LC–ESI-MS with a Simple Microgradient DeviceThis work presents an on-line combination of a simple microgradient device for reversed-phase liquid chromatography (LC) and electrospray ionization (ESI) tandem mass spectrometry (MS-MS).
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Single-Cell MS and High-Spatial-Resolution MS Imaging Under Ambient Conditions Using a Novel Sampling DeviceWe have developed a miniaturized, multifunctional device, called the "Single-Probe," that is capable of probing small targets and of sampling and ionizing molecular species.
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Analysis of Peptide Mixtures for Proteomics Research Using LC–ESI-MS with a Simple Microgradient DeviceThis work presents an on-line combination of a simple microgradient device for reversed-phase liquid chromatography (LC) and electrospray ionization (ESI) tandem mass spectrometry (MS-MS).
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LC–MS-MS Measurement of EPA Method 1694 Pharmaceuticals and Personal Care Products in WaterThis method increases sensitivity and reduces data acquisition time for a subset of pharmaceuticals and personal care products from the original EPA Method 1694 specifications.
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A Simple, Effective Solution for Characterization and Quantification of Microplastics by Pyrolysis-GC/MSWebinar Date/Time: Wed, Nov 6, 2024 2:00 PM EST
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Automated Solid Phase Extraction for Efficient Extraction of Fluoroquinolone Antibiotics from FishThe global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population.
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Analysis of Nitrosamines in MaltIn brewing, barley undergoes a malting process, the grain if first drenched to make it germinate and then dried in kilns to capture the sugar and flavor compounds for the brewing process.
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Automated Solid Phase Extraction for Efficient Extraction of Fluoroquinolone Antibiotics from FishThe global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population.
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Automated Solid Phase Extraction for Efficient Extraction of Fluoroquinolone Antibiotics from FishThe global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population.
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CAPCELL CORE ADME S2.7, a Novel Adamantyl Stationary Phase, Alternative to C18 for Improved Separation of MetabolitesCAPCELL CORE ADME S2.7 (ADME) is a column packed with a novel stationary phase of superficially porous silica (core shell particle) modified by adamantyl functional groups.
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CAPCELL CORE ADME S2.7, a Novel Adamantyl Stationary Phase, Alternative to C18 for Improved Separation of MetabolitesCAPCELL CORE ADME S2.7 (ADME) is a column packed with a novel stationary phase of superficially porous silica (core shell particle) modified by adamantyl functional groups.
Latest:
CAPCELL CORE ADME S2.7, a Novel Adamantyl Stationary Phase, Alternative to C18 for Improved Separation of MetabolitesCAPCELL CORE ADME S2.7 (ADME) is a column packed with a novel stationary phase of superficially porous silica (core shell particle) modified by adamantyl functional groups.
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Versatility of the Multi-Mode Scherzo SS-C18 in the Retention of Polar NeurotransmittersPolar neurotransmitters are difficult to retain using ODS columns. In this work we show two different methods to retain these polar analytes on the multi-mode Scherzo SS-C18 column. The versatility in retention characteristics with simple changes in mobile phase is highlighted.
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GC/GC–MSA snapshot of key trends and developments in the GC/GC–MS sector according to selected panelists from companies exhibiting at Analytica 2018.
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Aiding the Development of Extraction Procedures with Response Surface MethodologyWhen developing analytical methods, several parameters are often considered, things like solvent type and amount, sample size, pH, sorptive phases, temperature, time, and more. While some of these considerations can be considered unimportant in a given situation and experience and chemical knowledge can guide us to appropriate starting points, extraction method development is often a one-parameter-at-a-time proposition. A family of statistical approaches, which fall under the category of response surface methodology, are available to screen and optimize several parameters simultaneously.
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The Future of Instrumentation and Columns in Liquid ChromatographyAlthough smaller advances have been made in the past decades, the question remains whether further extending operating pressure and decreasing particle size remains a feasible approach, or whether drastically novel approaches are required.
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Using Compact Mass Spectrometry for Detection and Quantitation of Cannabis-Related CompoundsCompact mass spectrometry, in combination with suitable sample introduction techniques-such as the atmospheric solids analysis probe, thin-layer chromatography, and classical liquid chromatography techniques-can be used effectively for the detection and quantification of cannabinoids and pesticides in cannabis-related material and contraband.
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Solvent Assisted Ionization Mass Spectrometry for Screening and Quantification of Counterfeit DrugsExperiments presented here demonstrate the suitability of LC–SAI-MS for the detection and quantification of pharmaceuticals, with limits of detection in the low parts-per-trillion range. A comparison of LC–ESI-MS to LC–SAI-MS also yielded favorable results for SAI.
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Advanced Antibody–Drug Conjugate Structural Characterization by Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry Using Complementary ApproachesWith this method, a single injection was sufficient to characterize the amino acid sequence with complete sequence coverage. In addition, glycosylation and drug-loaded peptides could be identified from MS/MS spectra. A drug-loaded peptide fragmentation mass spectra study yielded drug-specific fragments, which reinforced the confidence about the identifications. The results reveal the ability of the sheathless CZE–MS/MS method to characterize an ADC’s primary structure in a single experiment.
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Comprehensive Multilevel Characterization of Biologics Using Sheathless Capillary Electrophoresis Hyphenated to Tandem Mass SpectrometryAn analytical methodology for the characterization of the primary structure of biotherapeutic proteins using sheathless CE–ESI-MS-MS instrumentation is presented. For the first time, complete sequence coverage can be achieved using a bottom-up proteomic approach from a single analysis of a tryptic digest. In a biosimilarity assessment, a single amino acid substitution was detected.
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Advanced Antibody–Drug Conjugate Structural Characterization by Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry Using Complementary ApproachesWith this method, a single injection was sufficient to characterize the amino acid sequence with complete sequence coverage. In addition, glycosylation and drug-loaded peptides could be identified from MS/MS spectra. A drug-loaded peptide fragmentation mass spectra study yielded drug-specific fragments, which reinforced the confidence about the identifications. The results reveal the ability of the sheathless CZE–MS/MS method to characterize an ADC’s primary structure in a single experiment.
