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Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
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An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
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An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
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Rapid Analysis of Selected Benzodiazepines by Automated SPE–MS-MSA new method was developed and validated using automated on-line solid-phase extraction (SPE) with tandem mass spectrometry (MS). Urine samples were enzyme-hydrolyzed and diluted before detection. The validated method was applied to positive authentic urine samples to evaluate concordance with high performance liquid chromatography (HPLC)–MS-MS results.
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Rapid Analysis of Selected Benzodiazepines by Automated SPE–MS-MSA new method was developed and validated using automated on-line solid-phase extraction (SPE) with tandem mass spectrometry (MS). Urine samples were enzyme-hydrolyzed and diluted before detection. The validated method was applied to positive authentic urine samples to evaluate concordance with high performance liquid chromatography (HPLC)–MS-MS results.
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An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
Latest:
An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
Latest:
An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
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Ion Manipulation by Digital Waveform TechnologyDigital waveform technology is emerging as a powerful tool in mass spectrometry (MS). Digital quadrupoles rely on precise control of frequency rather than voltage, which allows these devices to access a greatly extended mass range
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Ion Manipulation by Digital Waveform TechnologyDigital waveform technology is emerging as a powerful tool in mass spectrometry (MS). Digital quadrupoles rely on precise control of frequency rather than voltage, which allows these devices to access a greatly extended mass range
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Gas Chromatography with Reduction Gas Detection for the Characterization of Parts- Per-Billion Levels of Ethylene in Various MatricesA highly sensitive and selective mercuric oxide–based reduction gas detector was successfully used for parts-per-billion level gas chromatography (GC) determination of ethylene in various matrices such as in the monitoring of fruit ripening, ambient air, and industrial solvents.
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Gas Chromatography with Reduction Gas Detection for the Characterization of Parts- Per-Billion Levels of Ethylene in Various MatricesA highly sensitive and selective mercuric oxide–based reduction gas detector was successfully used for parts-per-billion level gas chromatography (GC) determination of ethylene in various matrices such as in the monitoring of fruit ripening, ambient air, and industrial solvents.
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Gas Chromatography with Reduction Gas Detection for the Characterization of Parts- Per-Billion Levels of Ethylene in Various MatricesA highly sensitive and selective mercuric oxide–based reduction gas detector was successfully used for parts-per-billion level gas chromatography (GC) determination of ethylene in various matrices such as in the monitoring of fruit ripening, ambient air, and industrial solvents.
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Possibilities and Limitations of Aqueous Temperature Responsive Liquid Chromatography in Comprehensive 2D–LCAnalyzing representative standard mixtures, APIs, and synthetic impurities shows that when TRLC is combined with RPLC in 2D-LC, separation performance is improved. We explain why.
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Advances in Microsampling for In Vivo Pharmacokinetic StudiesAdvances in Microsampling for In Vivo Pharmacokinetic Studies in Rodents
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Advances in Microsampling for In Vivo Pharmacokinetic StudiesAdvances in Microsampling for In Vivo Pharmacokinetic Studies in Rodents
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Advances in Microsampling for In Vivo Pharmacokinetic StudiesAdvances in Microsampling for In Vivo Pharmacokinetic Studies in Rodents
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Trace Metabolic Profiling and Pathway Analysis of Clomazone Using LC–MS-MS and High Resolution MSDetection, analysis, and characterization of low-abundant metabolites remain an unresolved problem in metabolic studies. In this study, we report a novel approach to address this challenge. The current methodology is derived from the predictive multiple reaction monitoring (pMRM) mode available on triple-quadrupole linear ion trap mass spectrometry (MS) systems. The pMRM mode offers the highest sensitivity among various acquisition modes for studying trace levels of metabolites of the herbicide clomazone in plants. Additionally, this method allows for the identification of positional isomers of metabolites.
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High-Resolution Time-of-Flight Mass Spectrometry for Rapid Petroleum CharacterizationThe application of high-resolution TOF-MS to petroleomics is presented, and the basic theory of each type of ultrahigh-resolution mass spectral platform is briefly explained.
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Enantiomeric Separation of Proton Pump Inhibitors Using Polysaccharide-Based Chiral Stationary Phases in Reversed-Phase HPLC ConditionsThe chiral analysis and purification of proton pump inhibitors (PPIs) has become a popular topic as more of these drugs fall out of patent protection each year. Due to their wide range of enantiomeric selectivity, a set of polysaccharide-based chiral stationary phases (CSPs) was screened to identify methods for the successful enantioseparation of four benzimidazoles; rabeprazole, lansoprazole, omeprazole, and pantoprazole.
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New Developments in the Analysis of Complex Environmental MatricesNew Developments in the Analysis of Complex Environmental Matrices
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Separation Science in Drug Development, Part 1: High-Throughput PurificationThis instalment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery. It describes the use of reversed-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC) for purifying diverse samples in a centralized laboratory setting. A case study is used to illustrate the principles and rationales for selecting operating parameters for these applications. This is the first instalment of four articles on “Separation Science in Drug Development” to describe the modern practice of separation science in supporting small-molecule drug discovery and development.
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Separation Science in Drug Development, Part 1: High-Throughput PurificationThis instalment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery. It describes the use of reversed-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC) for purifying diverse samples in a centralized laboratory setting. A case study is used to illustrate the principles and rationales for selecting operating parameters for these applications. This is the first instalment of four articles on “Separation Science in Drug Development” to describe the modern practice of separation science in supporting small-molecule drug discovery and development.
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Separation Science in Drug Development, Part II: High-Throughput CharacterizationThis installment provides an overview of high-throughput characterization techniques of drug leads to support small molecule drug discovery programs in a pharmaceutical company. A myriad of analytical chemistry techniques including separation science methodologies are used to confirm the structures and identities, quantitating the concentrations of stock solutions, and measuring key physicochemical properties of the new chemical entities (NCE). A case study is used here to illustrate the details of these applications in high-throughput characterization.
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Another Milestone in the Books for LCGCThis month marks another major milestone for LCGC: 35 years of successfully publishing “solutions for separation scientists.” I would be remiss if I did not thank you, our readers, as well as the tireless staff that work so hard to bring you this publication every month. In kind, I would also like to thank our columnists for their helpful contributions and willingness to share their expertise with our audience. Our advertisers also deserve a round of applause for supporting our business and counting on us to deliver successful products across the industry.
