Multi-Dimensional Chromatography
The Wednesday afternoon session on multi-dimensional chromatography includes two talks from instrument vendors.
The Wednesday afternoon session on multi-dimensional chromatography includes two talks from instrument vendors.
The first presentation, “The Analysis of Petrochemical Samples by 2D-GC Combined with High-Resolution Mass Spectrometry” by A. John Dane, Koji Okuda, and Robert B. Cody of JEOL USA, Inc., discusses comprehensive two-dimensional gas chromatography (GCxGC) used in combination with high-resolution mass spectrometry (HRMS) for the analysis of complex mixtures. The talk will report on details of the analysis of several petrochemical samples using GCxGC in combination with a new high-resolution time-of-flight (TOF) mass spectrometer.
The next talk, “GC×GC with Simultaneous Mass Spectrometry/Flame ionization Detection for Complete Petrochemical Analysis,” presents the work of Pete Grosshan, Matthew Edwards, Dave Wevill, Chris Hall, and Nick Bukowski of Markes International. The talk will discuss the use of parallel detection GC×GC to enable both targeted and nontargeted approaches to be performed simultaneously-with TOF-mass spectrometry (MS) for confident identification and a flame ionization detector (FID) for robust quantitation. The speakers also plan to demonstrate tandem ionization for simultaneous acquisition of both hard and soft EI spectra-thus, unlocking the fine detail of the sample composition.
This session will be held from 2:30 to 3:20 pm in room 370 E.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
