This article describes the evolution of traditional solid-phase extraction (SPE) into new techniques that are customized to the characteristics of specific matrices, including the removal of β-glucuronidase from urine samples and the removal of phospholipids and proteins from plasma samples.
The chiral analysis and purification of proton pump inhibitors (PPIs) has become a popular topic as more of these drugs fall out of patent protection each year. Due to their wide range of enantiomeric selectivity, a set of polysaccharide-based chiral stationary phases (CSPs) was screened to identify methods for the successful enantioseparation of four benzimidazoles; rabeprazole, lansoprazole, omeprazole, and pantoprazole.
A summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
The presence of per- and polyfluoralkyl substances (PFAS) in water is an important health and environmental concern. Liquid chromatography–mass spectrometry (LC–MS) has been established as the most suitable technology for monitoring these substances. A method is described, using EPA 8327, for PFAS analysis in groundwater, surface water, and wastewater.
This article evaluates ASTM D7979-16 for the “direct” analysis of 30 PFCs and 19 mass-labeled surrogates. Instead of using solid-phase extraction, the PFCs were solubilized in a methanol–water mix and filtered if necessary, and the sample was injected into a LC–MS/MS system.
This note looks at the analysis of N-nitrosamines in rubber teats, soothers, and toys, with specific focus on babies and young children under UK method BS EN 71-12:2016.
This article discusses the detection of N-nitroso compounds (NOC) in a range of different food and beverages.
Direct exposure probe (DEP) coupled to the Pegasus HT, time-of-flight mass spectrometer, was used for the identification of synthetic cannabinoids in MTN-series compounds.
Direct exposure probe (DEP) coupled to the Pegasus HT, time-of-flight mass spectrometer, was used for the identification of synthetic cannabinoids in MTN-series compounds.
There has been a revival of supercritical fluid chromatography (SFC) in recent years, especially in the chiral preparative field, but also more recently in the analytical area. However, SFC is considerably more complex than liquid chromatography (LC), mainly because of the compressibility of the mobile phase. One can say that SFC is a “rubber variant” of LC where everything considered constant in LC varies in SFC. In this review, we go through advances in theory, instrumentation, and novel applications.
Glyphosate is a broad-spectrum herbicide widely used around the world. Monitoring of glyphosate in crops and water is mandated in many countries.
Despite the utility of high performance liquid chromatography (HPLC) simulators, we found that all the free and low-cost simulators were outdated or had extremely limited functionality, so we created one that addressed these shortcomings. We developed a sophisticated, open-source HPLC simulator that is available for free as well as a version for Android users called "HPLC Simulator." Here we discuss a few questions that the simulator can help answer: Why are peaks narrower in gradient elution? What is gradient delay and how does it affect a separation?
Despite the utility of high performance liquid chromatography (HPLC) simulators, we found that all the free and low-cost simulators were outdated or had extremely limited functionality, so we created one that addressed these shortcomings. We developed a sophisticated, open-source HPLC simulator that is available for free as well as a version for Android users called "HPLC Simulator." Here we discuss a few questions that the simulator can help answer: Why are peaks narrower in gradient elution? What is gradient delay and how does it affect a separation?
This article describes a technique based on pseudo-random injection sequences to perform rapid sample injections.
The benefits of a robustness assessment for the analysis of a NIST mAb using a wide pore C4 LC column are described.
The biologically active form of vitamin D is an important analytical target in both research and clinical practice.
For lurasidone treatment adherence testing, an untargeted high-resolution mass spectrometry method was employed, using known positive human urine samples to identify the lurasidone metabolites and their relative abundance in urine.
Marijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world.
The biologically active form of vitamin D is an important analytical target in both research and clinical practice.
For lurasidone treatment adherence testing, an untargeted high-resolution mass spectrometry method was employed, using known positive human urine samples to identify the lurasidone metabolites and their relative abundance in urine.
Marijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world.
The biologically active form of vitamin D is an important analytical target in both research and clinical practice.
Enzyme immunoassay (EIA) is a conventional drug screening technique, but it can be limited by cross-reactivity that can lead to high false positive rates.
Marijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world.
This study focuses on United States Environmental Protection Agency (US EPA) Method 524.3 for volatile organic compounds (VOCs) in water using gas chromatography–mass spectrometry (GC–MS).