The development of a microfabricated comprehensive GC that can be used as a portable measurement device.
Liquid chromatography coupled to triple quadrupole tandem mass spectrometry (LC–MS–MS) in multiple reaction monitoring (MRM) mode is widely considered as the gold standard for pesticide analysis. In this article recent developments in LC–MS–MS technology to meet increasing regulatory demands and productivity targets in quality control and contract laboratories are explored.
Most plants used in traditional Chinese medicine must be processed before their medicinal usage; hence the effective ingredients may differ from those in the freshly harvested plant extracts. In this work, we present a fast and generic approach using sub-2-?m liquid chromatography–time-of-flight–mass spectrometry (sub-2-?m-LC–TOF-MS) coupled with multivariate statistical data analysis to systematically profile ingredient changes between fresh and processed samples of huang jing.
We explore advancements in silica particles for liquid chromatography, focusing on the shift toward improved monodispersity and its impact on chromatographic parameters, efficiency, backpressure, and sensitivity in high-performance liquid chromatography (HPLC).
When one walks into either a chromatography research laboratory at a university or a chromatography testing or R&D laboratory in a North American company, one may notice one common factor: A significant number (more than 50%) of researchers are of Chinese origin. This was not the case 25 years ago.
Developments in pulsed electrochemical detection are traced through the progression of its waveforms.
The development of a microfabricated comprehensive GC that can be used as a portable measurement device.
It is often possible to achieve better sensitivity and lower limits of detection and quantitation using standard gas chromatography instrumentation. Paying attention to fundamental variables-like sample solvent, initial oven temperature hold, carrier gas operating mode, and thermal gradients- can lead to much improved method performance.
In this installment, we discuss fluorescence-detection size exclusion chromatography (FSEC) technology and its implications in protein characterization, specifically the development and characterization of biologics.
In this installment, we discuss fluorescence-detection size exclusion chromatography (FSEC) technology and its implications in protein characterization, specifically the development and characterization of biologics.
Here's how these new reference standards were characterized.
Describing developments in LC–MS and GC–MS that reveal the ageing chemistry of whiskey aged in oak barrels.
Pomegranates are loaded with antioxidants and millions of people turn to pomegranate juice for its many health benefits, but every time you take a sip from a bottle of the popular juice, how much of the actual fruit are you consuming?
Phenomenex Application Note
This article demonstrates the superiority of the GC-MS approach over spectrophotometry.
An exploration of LDTD-MS-MS and how it compares to HPLC–MS-MS techniques in terms of sensitivity, robustness, and speed in an in-vivo drug discovery application
Here, the process to build an accurate mass database is thoroughly described and applications are commented on.
Certain considerations must be made with regards to the overall ?ow path used in a SFC analysis to ensure additional obstacles are not introduced inadvertently. This article provides more information.
The development of a microfabricated comprehensive GC that can be used as a portable measurement device.
The development of a microfabricated comprehensive GC that can be used as a portable measurement device.
This article demonstrates the superiority of the GC-MS approach over spectrophotometry.
The metabolomics workflow described here combines untargeted (discovery) quadrupole time-of-flight (Q-TOF) liquid chromatography–mass spectrometry (LC–MS), targeted (confirmation) triple-quadrupole LC–MS-MS, and sophisticated data mining as an effective means to elucidate metabolite changes.
High performance time-of-flight mass spectrometry (TOF-MS) is applied to the analysis and characterization of complex biological samples. High mass accuracy, high resolution, and accurate relative isotope abundance are all applied to the determination of analytes covering a range of concentrations in complex matrices including plasma and urine. Qualitative and quantitative evaluations are provided and include demonstrations of the impact of high-performance MS on sensitivity and selectivity. The ability to leverage high-performance MS in conjunction with a broad dynamic range in rapid ultrahigh-pressure liquid chromatography (UHPLC) analyses to identify unknowns and to propose putative metabolic biomarkers is demonstrated. The impact of speed of analysis and selectivity to the depth of coverage and accuracy of the analyses are discussed.
A look at the role of system suitability tests (SSTs) during performance qualification (PQ).
The development of a microfabricated comprehensive GC that can be used as a portable measurement device.
One of the biggest debates in clinical medicine currently revolves around understanding the proper levels of vitamin D in patients' plasma.