Author


Phillip Homewood

Latest:

Lab-on-a-Chip GC for Environmental Research

The development of a microfabricated comprehensive GC that can be used as a portable measurement device.


Zicheng Yang

Latest:

Positive-Negative Switching LC–MS–MS for Quantification of Pesticides in Juice

Liquid chromatography coupled to triple quadrupole tandem mass spectrometry (LC–MS–MS) in multiple reaction monitoring (MRM) mode is widely considered as the gold standard for pesticide analysis. In this article recent developments in LC–MS–MS technology to meet increasing regulatory demands and productivity targets in quality control and contract laboratories are explored.


Yue Gao

Latest:

Comparison of Extracts from Dry and Alcohol-Steamed Root of Polygonatum kingianum (Huang Jing) by Sub-2-µm–LC–TOF-MS

Most plants used in traditional Chinese medicine must be processed before their medicinal usage; hence the effective ingredients may differ from those in the freshly harvested plant extracts. In this work, we present a fast and generic approach using sub-2-?m liquid chromatography–time-of-flight–mass spectrometry (sub-2-?m-LC–TOF-MS) coupled with multivariate statistical data analysis to systematically profile ingredient changes between fresh and processed samples of huang jing.


Ken Butchart

Latest:

The Effect of Particle Monodispersity in HPLC Column Performance

We explore advancements in silica particles for liquid chromatography, focusing on the shift toward improved monodispersity and its impact on chromatographic parameters, efficiency, backpressure, and sensitivity in high-performance liquid chromatography (HPLC).


Yan-Bo Yang

Latest:

Chinese American Chromatography Association Provides Networking, Career Support, and a Sense of Community

When one walks into either a chromatography research laboratory at a university or a chromatography testing or R&D laboratory in a North American company, one may notice one common factor: A significant number (more than 50%) of researchers are of Chinese origin. This was not the case 25 years ago.


William R. LaCourse

Latest:

Pulsed Electrochemical Detection: Waveform Evolution

Developments in pulsed electrochemical detection are traced through the progression of its waveforms.


Robin J.P. Grenfell

Latest:

Lab-on-a-Chip GC for Environmental Research

The development of a microfabricated comprehensive GC that can be used as a portable measurement device.


Dawn Wallace Watson

Latest:

Optimizing Sensitivity in GC–FID Analysis

It is often possible to achieve better sensitivity and lower limits of detection and quantitation using standard gas chromatography instrumentation. Paying attention to fundamental variables-like sample solvent, initial oven temperature hold, carrier gas operating mode, and thermal gradients- can lead to much improved method performance.


Sunit Maity

Latest:

Fluorescence-Detection Size-Exclusion Chromatography — An Analytical Technique with Multiple Applications

In this installment, we discuss fluorescence-detection size exclusion chromatography (FSEC) technology and its implications in protein characterization, specifically the development and characterization of biologics.  


Vivek Halan

Latest:

Fluorescence-Detection Size-Exclusion Chromatography — An Analytical Technique with Multiple Applications

In this installment, we discuss fluorescence-detection size exclusion chromatography (FSEC) technology and its implications in protein characterization, specifically the development and characterization of biologics.  



Dagmara Dabrowska

Latest:

Advances in the Ageing Chemistry of Distilled Spirits Matured in Oak Barrels

Describing developments in LC–MS and GC–MS that reveal the ageing chemistry of whiskey aged in oak barrels.


Robert Moreschi

Latest:

How Much Pomegranate Is In Pomegranate Juice?

Pomegranates are loaded with antioxidants and millions of people turn to pomegranate juice for its many health benefits, but every time you take a sip from a bottle of the popular juice, how much of the actual fruit are you consuming?



Gerard G. Dumancas

Latest:

Quantification of Total w-6 and w-3 Fatty Acids and w-6/w-3 Ratio in Human Serum Using GC-MS

This article demonstrates the superiority of the GC-MS approach over spectrophotometry.


Mark Denn

Latest:

Laser Diode Thermal Desorption Tandem Mass Spectrometry for Simultaneous Quantitation of Metformin and Sitagliptin in Mouse and Human Dried Blood Spots

An exploration of LDTD-MS-MS and how it compares to HPLC–MS-MS techniques in terms of sensitivity, robustness, and speed in an in-vivo drug discovery application


Roberto Romero-González

Latest:

An Accurate Mass Database for the Analysis of Pesticides and Veterinary Drugs using Liquid Chromatography-High-Resolution Mass Spectrometry

Here, the process to build an accurate mass database is thoroughly described and applications are commented on.


John Batts

Latest:

Flow Path Considerations for Improved SFC Analyses

Certain considerations must be made with regards to the overall ?ow path used in a SFC analysis to ensure additional obstacles are not introduced inadvertently. This article provides more information.



Jaydene Halliday

Latest:

Lab-on-a-Chip GC for Environmental Research

The development of a microfabricated comprehensive GC that can be used as a portable measurement device.


Gergely Vargha

Latest:

Lab-on-a-Chip GC for Environmental Research

The development of a microfabricated comprehensive GC that can be used as a portable measurement device.


Lisa Reilly

Latest:

Quantification of Total w-6 and w-3 Fatty Acids and w-6/w-3 Ratio in Human Serum Using GC-MS

This article demonstrates the superiority of the GC-MS approach over spectrophotometry.


Shane E. Tichy

Latest:

Metabolomics Workflows: Combining Untargeted Discovery-Based and Targeted Confirmation Approaches for Mining Metabolomics Data

The metabolomics workflow described here combines untargeted (discovery) quadrupole time-of-flight (Q-TOF) liquid chromatography–mass spectrometry (LC–MS), targeted (confirmation) triple-quadrupole LC–MS-MS, and sophisticated data mining as an effective means to elucidate metabolite changes.


Michael Mason

Latest:

A New Path to High-Resolution HPLC–TOF-MS — Survey, Targeted, and Trace Analysis Applications of TOF-MS in the Analysis of Complex Biochemical Matrices

High performance time-of-flight mass spectrometry (TOF-MS) is applied to the analysis and characterization of complex biological samples. High mass accuracy, high resolution, and accurate relative isotope abundance are all applied to the determination of analytes covering a range of concentrations in complex matrices including plasma and urine. Qualitative and quantitative evaluations are provided and include demonstrations of the impact of high-performance MS on sensitivity and selectivity. The ability to leverage high-performance MS in conjunction with a broad dynamic range in rapid ultrahigh-pressure liquid chromatography (UHPLC) analyses to identify unknowns and to propose putative metabolic biomarkers is demonstrated. The impact of speed of analysis and selectivity to the depth of coverage and accuracy of the analyses are discussed.




Claus Feuäner

Latest:

Why System Suitability Tests Are Not a Substitute for Analytical Instrument Qualification (Part 3): Performance Qualification (PQ)

A look at the role of system suitability tests (SSTs) during performance qualification (PQ).


Alastair C. Lewis

Latest:

Lab-on-a-Chip GC for Environmental Research

The development of a microfabricated comprehensive GC that can be used as a portable measurement device.


Phil Koerner

Latest:

25-Hydroxyvitamin D2/D3 Analysis in Human Plasma Using LC–MS

One of the biggest debates in clinical medicine currently revolves around understanding the proper levels of vitamin D in patients' plasma.