Breaking Through LC/MS Barriers: Advancing Cyclic Peptide Characterization in Drug Development With the MOBIE Next-Gen Separations Platform

Join our webcast to learn how advanced ion mobility technology is transforming cyclic peptide drug development with greater accuracy and efficiency.

Register Free: https://www.chromatographyonline.com/lcgc/mobie

Event Overview:

Join this in-depth webcast that explores the transformative impact of the MOBIE platform on cyclic peptide drug development. Cyclic peptides, known for their stability and high specificity, are promising therapeutic agents in the fight against cancer, infections, and autoimmune diseases. However, developing effective cyclic peptides presents numerous challenges, including poor pharmacokinetics, efficacy, and toxicity. Traditional methods like liquid chromatography tandem-mass spectrometry (LC-MS/MS) often struggle with resolving isomeric linear peptide metabolites, posing significant risks in safety, efficacy, and regulatory approval.

In this webcast, Komal Kedia, PhD, will share how she leveraged MOBIE’s high-resolution ion mobility-mass spectrometry (IM-MS) system to achieve a 72% reduction in run times, 200% greater resolving power, and enhanced accuracy in identifying “soft spots” prone to enzymatic degradation. With insights from the case study, learn how MOBIE’s advanced separation technology simplifies workflows, reduces costs, and increases confidence in cyclic peptide characterization.

Key Learning Objectives:

• Learn about the specific hurdles in designing stable and effective cyclic peptides, particularly in identifying and resolving “soft spots” prone to enzymatic degradation.
• Discover how IM-MS, particularly the MOBIE platform, offers a 200% improvement in resolving power and faster analysis to distinguish isomeric and stereoisomeric peptide metabolites.
• Learn how Merck achieved a 72% reduction in run times for cyclic peptide analysis, leading to higher throughput, reduced costs, and streamlined workflows in drug development.

Who Should Attend:
• Scientists who play a role in chemistry, manufacturing, and controls including:

• Medicinal chemists
• Analytical chemists
• Peptide chemists
• Process chemists
• Proteomics specialists
• Mass spectrometry analysts
  

Speaker:

Komal Kedia, PhD
Associate Principal Scientist
Merck

Komal Kedia, PhD, earned her PhD in analytical chemistry from Brigham Young University in the lab of Steven Graves, PhD, followed by a postdoc at Pacific Northwest National Laboratory under Richard Smith, PhD, inventor of structures for lossless ion manipulation (SLIM). Throughout her career, she has led various biomarker research projects. As an associate principal scientist at Merck, she focuses on PK/PD studies and biomarker analysis. She also leads a project developing advanced ion mobility technology to address various analytical challenges.

Register Free: https://www.chromatographyonline.com/lcgc/mobie