Author
Latest:
An Investigation into the Use of Alternate Carrier Gases for the Determination of Volatile Organic Compounds in Water by GC–MSThis study focuses on United States Environmental Protection Agency (US EPA) Method 524.3 for volatile organic compounds (VOCs) in water using gas chromatography–mass spectrometry (GC–MS).
Latest:
GC–MS Analysis of an Herbal Medicinal Remedy to Identify Potential Toxic CompoundsIn most countries, herbal medicinal products (HMPs) are introduced into the market without proper scientific evaluation or enforced safety and toxicological studies.
Latest:
Fast and Accurate Identification of Pesticides by Direct Analysis in Real Time (DART) Ionization with Orbitrap Mass SpectrometryA method incorporating direct analysis in real time (DART) ionization and Thermo Scientific™ Orbitrap™ high-resolution mass spectrometry for rapid analysis and identification of contaminating substances in water.
Latest:
Asymmetric Flow Field-Flow Fractionation Analysis of Engineered Nanoparticles in Mouthwashes and Their Interaction with SalivaThe evaluation of the oral uptake of engineered nanoparticles (ENPs) contained in personal care products like mouthwashes is of great relevance to estimate the potential hazards and the toxicity of engineered nanomaterials (ENMs). Various experiments were performed while two commercially available mouthwash products (named M1 and M2) were selected as samples of interest. Asymmetric flow field‑flow fractionation (AF4) was chosen and optimized as the particle separation technique and two detectors were on-line coupled while dynamic light scattering (DLS) was used for evaluation and signals obtained by ultraviolet–visible (UV–vis) detection at 254 nm were used to gather additional information about the fate of the ENPs.
Latest:
Avoiding Reversed-Phase Chromatography Problems Through Informed Method Development Practices: Choosing the Stationary-Phase ChemistryUnderstanding the chemistry of embedded polar group and perfluorophenyl phases leads to better decisions during method developement
Latest:
Fast and Accurate Identification of Pesticides by Direct Analysis in Real Time (DART) Ionization with Orbitrap Mass SpectrometryA method incorporating direct analysis in real time (DART) ionization and Thermo Scientific™ Orbitrap™ high-resolution mass spectrometry for rapid analysis and identification of contaminating substances in water.
Latest:
Application of Ambient Sampling Portable Mass Spectrometry Toward On-Site Screening of Clandestine Drug OperationsWorldwide trends in illicit drug use and production have shifted toward an increase in synthetic analogues and the emergence of new variations in their manufacture.
Latest:
Anomalous Retention Prediction Using Modelling Software in Gradient Reversed-Phase Liquid Chromatography: Why it Can Occur and How to Prevent ItThe success of screening column and mobile phase combinations that generate dissimilar selectivity is highlighted in a typical method development strategy.
Latest:
Aflatoxin B1, B2, G1, G2 Food Safety Testing Prior to Automated SmartPrep® Extractor Solid-Phase ExtractionMycotoxin testing awareness has increased as countries involved in world trade of raw agriculture and processed consumer products rely on a safe global food supply
Latest:
Analysis of Complex Pharmaceuticals by Ultrahigh-Pressure Liquid Chromatography: Case Studies and Quality Control ImplicationsExperimental results and method validation data from two analytical case studies of complex small?molecule pharmaceuticals illustrates the utility and advantages of UHPLC in high-resolution separations.
Latest:
Fast Analysis with SFCSupercritical fluid chromatography (SFC) has been used by scientists in laboratories and manufacturing facilities for several decades.
Latest:
Liquid Chromatography of Carbohydrates in Human Food and Animal Feeding StuffsThis article discusses the liquid chromatography instrumentation (columns, mobile phases, and detectors) that can be applied to determine different carbohydrates in human food and animal feeds.
Latest:
A New HILIC Column for Saccharide AnalysisDue to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).
Latest:
HPLC UV Determination of Very High and Very Low Concentrations of Compounds in One RunAgilent Technologies
Latest:
Large-Scale Targeted Protein Quantification Using Wide Selected-Ion Monitoring Data-Independent AcquisitionThis article describes the development of a new data-independent acquisition (DIA) workflow for protein quantification that uses a mass spectrometer that combines three types of mass analyzers to achieve lower limits of detection (LOD), higher sensitivity, more accurate quantitative results, wider dynamic range, and better reproducibility than existing high-resolution accurate-mass (HRAM) tandem mass spectrometry (MS-MS) DIA workflows.
Latest:
There is No Time to Waste: Low-Pressure Gas Chromatography– Mass Spectrometry is a Proven Solution for Fast, Sensitive, and Robust GC–MS AnalysisLow-pressure gas chromatography (LPGC)–MS should be the first option in many GC–MS applications to provide fast, sensitive, and robust analyses; and the installation, instrumentation, and implementation of LPGC is possible in any GC–MS system.
Latest:
Analysis of Residual Solvents in Drug ProductsGC headspace analysis is commonly used to control volatile organic components in APIs. Methods are specified in U.S. Pharmacopeia General Chapter <467>.
Latest:
Application of Ambient Sampling Portable Mass Spectrometry Toward On-Site Screening of Clandestine Drug OperationsWorldwide trends in illicit drug use and production have shifted toward an increase in synthetic analogues and the emergence of new variations in their manufacture.
Latest:
When Bad Things Happen to Good Food: Application of HPLC to Detect Food AdulterationIn this instalment, guest authors Jeff Hurst and Kendra Pfeifer from Hershey Foods explore high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), and mass spectrometry (MS) approaches being adopted to keep ahead of the food adulteration game.
Latest:
Physicochemical Methods for Vectors and Ancillary Materials in Cellular and Gene TherapiesCellular and gene therapies (CGTs) have contributed significantly to the improvement of clinical outcomes for patients in the recent years. This paper discusses a range of physicochemical methods that play an important role in the difficult characterization of viral vectors, to meet the unique needs of CGT manufacturing process development, process and product characterization, and the quality control testing of these materials.
Latest:
Analysis of Complex Pharmaceuticals by Ultrahigh-Pressure Liquid Chromatography: Case Studies and Quality Control ImplicationsExperimental results and method validation data from two analytical case studies of complex small?molecule pharmaceuticals illustrates the utility and advantages of UHPLC in high-resolution separations.
Latest:
Translations Between Differing Liquid Chromatography Formats: Advantages, Principles, and Possible PitfallsThe numerous advantages of translating gradient chromatographic methods between the differing formats of LC have been explored and discussed. While translations in principle obey well defined chromatographic theories, the authors investigate a number of potential pitfalls that may result in poor translations as exhibited by selectivity differences, changes in efficiency, and hence failure to meet resolution system suitability criteria.
Latest:
Analysis of Complex Pharmaceuticals by Ultrahigh-Pressure Liquid Chromatography: Case Studies and Quality Control ImplicationsExperimental results and method validation data from two analytical case studies of complex small?molecule pharmaceuticals illustrates the utility and advantages of UHPLC in high-resolution separations.
