Author



Jean-Claude Tabet

Latest:

Ambient Ionization MS Analysis of Swabs Used for Explosives Detection

An analysis of the capabilities of direct analysis in real time (DART) and desorption electrospray ionization (DESI) sources for the analysis of contaminated fabrics


Paola Calza

Latest:

LC–HRMS Determination of Anticancer Drugs as Occupational Contaminants Applied to Photocatalytic Degradation of Molecules of Different Stability

Here, degradation compounds similar to those formed in metabolic or environmental pathways were generated by adopting a photocatalytic process, quantified in environmental samples by liquid chromatography with multiple-stage mass spectrometry (LC–MSn) analysis using an orbital trap instrument with an electrospray interface, and then identified in indoor environments alongside parent compounds.


Heiner Wegner

Latest:

Analysis of Fusarium Toxins Using LC–MS-MS: Application to Various Food and Feed Matrices

Co-occurrence of several mycotoxins (deoxynivalenol, zearalenone, T-2-toxin, HT-2 toxin) produced by field fungi, such as Fusarium graminearum and Fusarium culmorum, requires several analysis methods for their characterization. A reliable method for the determination of type A- and B-trichothecenes and zearalenone in cereal-based samples is presented. To achieve optimal mass spectrometric detection, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) were compared. Best results were obtained with ESI by implementing a two-period switching for the ionization polarity. The limit of quantification differs for each individual substance within the range 1–10 ppb. Mean recoveries using a standardized clean-up procedure were in the 54–93% range.


Zhou Bin

Latest:

Simultaneous Determination of Harpagoside and Its Metabolites in an Aspergillus niger Culture by Solid-Phase Extraction and HPLC

A new chromatography-based method for analyzing a traditional Chinese medicine and its metabolites.


I.N. Acworth

Latest:

The Spectro-Electro Array: A Novel Platform for the Measurement of Secondary Metabolites in Botanicals, Supplements, and Beverages

HPLC with diode-array and electrochemical-array detection overcomes sensitivity and specificity limitations in natural products analysis.



Stephan Koza

Latest:

Modern Size-Exclusion Chromatography Separations of Biosimilar Antibodies at Physiological pH and Ionic Strength

The state of protein-derived self-associated, aggregated, and fragmented impurities in therapeutics are critical quality attributes (CQAs) and are widely monitored using non-denaturing size-exclusion chromatography (SEC).


Zheng Ouyang

Latest:

The Future of Miniature Mass Spectrometers and a Path Forward: A Few Thoughts from an Academic Researcher

A discussion of the future role of miniature MS systems, the need for simplification in operation, the role of ambient ionization, and challenges in development and commercialization.


Walter J. Krol

Latest:

Significant Improvements in Pesticide Residue Analysis in Food Using the QuEChERS Method

The analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.


Khalil Divan

Latest:

Determination of Olive Oil Adulteration by Principle Component Analysis Using HPLC-Charged Aerosol Detection

Adulteration is a significant problem for the olive oil industry because of the product’s high value. With the demand for olive oil expected to rise significantly, this problem is set to increase. Reliable and accurate determinations of olive oil adulteration are therefore required to maintain product integrity. This article introduces a principle component analysis‑based approach that uses data obtained by high performance liquid chromatography (HPLC)-charged aerosol detection (CAD) to determine extra virgin olive oil adulteration by common vegetable oil adulterants. Using only sample dilution and analysis, the method could be used to assess olive oil quality relative to pomace oil.


Wolfgang Buchberger

Latest:

ISC 2014: The Sound of Chromatography

The hills will be alive with the sound of chromatography when the 30th International Symposium on Chromatography (ISC 2014) takes place from 14?18 September 2014 in Salzburg, Austria.


Ruben Garnica

Latest:

Low Level PAH Detection with an Extensive Dynamic Range

The analysis of PAHs in less than 16 min using hydrogen as carrier gas and the PerkinElmer? Clarus? SQ 8 GC/MS operating in SIM mode is presented. Detection limits down to 0.5 pg on-column and a wide dynamic range are reported.


Nobukazu Higashi

Latest:

Gas Chromatography with Soft Ionization Mass Spectrometry for the Characterization of Natural Products

The application of gas chromatography (GC) combined with atmospheric pressure chemical ionization mass spectrometry (GC–APCI-MS) and with supersonic molecular beam ionization mass spectrometry (GC–SMB-MS).


Praveen Kutty

Latest:

GCxGC–TOF-MS Complements Passive Sampling for the Screening of Pollutants in Water

A carefully chosen analytical technique can enhance the inherent advantages of passive sampling of watercourses over more traditional "grab" or "spot" sampling.


Thomas Wüthrich

Latest:

Screening by LC–MS-MS and Fast Chromatography: An Alternative Approach to Traditional Immunoassays?

A new technique was developed based on liquid chromatography coupled with tandem mass spectrometry to analyze drugs that are not part of current immunoassay screening, specifically zolpidem, zopiclone, and zaleplone, or "z-drugs."


Xiao-Ying Yu

Latest:

Probing Aqueous Surfaces by TOF-SIMS

A breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.


Frank David

Latest:

Polysorbate Analysis in Biopharmaceutical Applications—A Snapshot of the Analytical Toolbox

An overview of different approaches for the qualitative and quantitative analysis of polysorbates.


Ahmed Mostafa

Latest:

Sensitivity of Comprehensive Two-dimensional Gas Chromatography (GCXGC) Versus One-dimensional Gas Chromatography (1D GC)

In this article, the sensitivity of two-dimensional gas chromatography coupled to two different detectors - a time-offl ight mass spectrometer (GCXGC–TOF-MS) and a fl ame ionization detector (GC?GC–FID) - was compared to the sensitivity of conventional one-dimensional gas chromatography (GC–TOF-MS and GC–FID) by determining method detection limits (MDLs) for a series of different compounds with different polarities.


Youxuan Xu

Latest:

An Improved LC–MS–MS Method for the Determination of Clenbuterol in Human Urine

A sensitive method that reduces the number of false-positive results


Bart Tienpont

Latest:

Gas Chromatography with Soft Ionization Mass Spectrometry for the Characterization of Natural Products

The application of gas chromatography (GC) combined with atmospheric pressure chemical ionization mass spectrometry (GC–APCI-MS) and with supersonic molecular beam ionization mass spectrometry (GC–SMB-MS).


Wolfgang Radke

Latest:

Tips & Tricks: GPC/SEC Analysis of Aqueous Polymer Dispersions

Polymer dispersions are used in numerous applications including paints, binders, and adhesives. These complex mixtures usually contain polymeric components that contribute significantly to their physical and chemical properties.


Graham Mills

Latest:

Meeting Review: Latest Advances in the Analysis of Complex Environmental Matrices, 2019

A biennial meeting jointly organized by the Environmental Chemistry Group, Separation Sciences Group, and the Water Science Forum, and discussing the latest advances in the analysis of complex environmental matrices, is now in its eighth year. The most recent iteration of the event occurred on Friday 22 February 2019 in the Science Suite, Royal Society of Chemistry, Burlington House, in London, UK. This meeting review offers an overview of what is happening in the industry.



Nadia B. Cech

Latest:

Mass Spectrometry for Natural Products Research: Challenges, Pitfalls, and Opportunities

Correlating biological activity with chemical composition is the Holy Grail of natural product chemists. Is mass spectrometry the right tool for this challenge?


Douglas E. Raynie

Latest:

New Sample Preparation Products and Accessories for 2024

This yearly report on new products introduced in the preceding year, since March 2023, covers sample preparation instrumentation, supplies, and accessories.


Frank Dorman

Latest:

Analyzing Synthetic Cathinones Using Direct Sample Analysis Time-of-Flight Mass Spectrometry

Direct sample analysis coupled to high-resolution time-of-flight mass spectrometry (TOF-MS) may be effective at analyzing synthetic cathinones, especially for qualitative analysis, because it does not require potentially tedious sample preparation.


Megan L'Heureux

Latest:

THC Isomers in Cannabis: An EAS Interview with Brandy Young

Brandy Young, PhD, an analytical chemist with more than 15 years of experience, entered the cannabis industry in response to a recognized need for laboratory testing, aligning her expertise with the emerging demand in New York's active medical and adult-use cannabis programs. Here, she shares some background information on her Eastern Analytical Symposium (EAS) talk, which delves into the characterization of tetrahydrocannabinol (THC) isomers in cannabis products.


Nicolas Leroy

Latest:

Effective Cleanup and Analysis of Metronidazole from Foaming Facial Cleanser

When working with complex matrices such as personal care products, sample preparation is perhaps the most difficult step of the analysis process. By utilizing a targeted sample preparation technique, such as ion-exchange SPE, analysis can be significantly improved as compared to less targeted techniques such as liquid-liquid extraction.


Scott Hazard

Latest:

Purge-and-Trap GC Analysis of Methane in Water Samples Associated with Hydraulic Fracturing

Shale gas reservoirs, such as the Marcellus shale reserve in Pennsylvania and Barnett shale reserve in Texas are a growing source of natural gas in the United States. Hydraulic fracturing or "fracking" involves pumping water, sand, and chemicals at extremely high pressure into deep underground wells to crack open hydrocarbon-rich shale formations and extract natural gas.