Tosoh Bioscience

Switching the GPC/SEC solvent from THF to 2-methyl-THF provides an easy swap to provide a greener, safer, and less toxic option.

Webinar Date/Time: Tuesday, September 24th, 2024 Session 1: 9:00 AM EDT | 6:00 AM PDT | 2:00 PM BST | 3:00 PM CEST Session 2: 1:00 PM EDT | 10:00 cAM PDT | 6:00 PM BST | 7:00 PM CEST

Characterizing the ratio of tumor-killing payload to cancer-binding antibody (DAR) is a critical quality attribute that helps determine the potential potency of a given antibody-drug conjugate (ADC) candidate. The TSKgel® HIC-ADC Butyl column, developed by Tosoh Bioscience, enables improved HIC-based separations for quantifying the DAR of ADCs.

Learn how to improve the accuracy of viral particle analysis using the combination of SEC-MALS and IEX.

This innovative AEX method replaces toxic TMAC with non-toxic choline-Cl, ensuring safety and efficiency in AAV capsid analysis, applicable across multiple AAV serotypes.

The increased demand for AAV therapies can be met by using LC-MALS to efficiently assess AAV purity without the financial burden.

Webinar Date/Time: Airing 1: Wednesday, January 31, 2024 at 9am EST | 2pm GMT | 3pm CET Airing 2: Wednesday, January 31, 2024 at 1pm EST | 12pm CST | 10am PST

Webinar Date/Time: Thursday, December 7, 2023 at 9am EST | 2pm GMT | 3pm CET Thursday, December 7, 2023 at 1pm EST | 12pm CST | 10am PST

Webinar Date/Time: Thursday, September 7, 2023 at 9am EST and 2pm ES

MALS detection coupled with AEX chromatography can aid in the characterization of AAVs.

Adeno-associated viruses (AAVs) have recently gained significant attention in the field of gene and cell therapy. In this podcast, an overview of chromatography techniques for the characterization of AAVs will be discussed by Dr. Phu Duong. The discussion will highlight the most versatile and powerful detection technique to accurately characterize AAVs that is easy to adapt and implement.

Determine down to 8x10^9 AAV capsids and separate impurities of AAV samples by separation using a mixed-bed SEC column & highly sensitive MALS detection.

Webinar Date/Time: Wed, Jun 28, 2023 9:00 AM EDT

Polymers are gaining more attention in many new fields such as pharmaceutical applications. However, optimizing the final properties of the polymers associated with these new application areas is challenging for chemists and analysts. Polymer architecture plays a crucial role to optimize the end use or process-related properties. Size exclusion chromatography in combination with advanced detectors such as light scattering, viscometer, and refractive index is a powerful tool for the comprehensive characterization of macromolecules with various architectures. In this podcast, Dr. Subin Damodaran will explain how to understand the structural properties of a polymer by providing their molecular sizes such as radius of gyration (Rg ) and hydrodynamic radius (Rh), and intrinsic viscosity.

Polymers are gaining more attention in many new fields such as pharmaceutical applications. However, optimizing the final properties of the polymers associated with these new application areas is challenging for chemists and analysts. Polymer architecture plays a crucial role to optimize the end use or process-related properties. Size exclusion chromatography in combination with advanced detectors such as light scattering, viscometer, and refractive index is a powerful tool for the comprehensive characterization of macromolecules with various architectures. In this podcast, Dr. Subin Damodaran will explain how to understand the structural properties of a polymer by providing their molecular sizes such as radius of gyration (Rg ) and hydrodynamic radius (Rh), and intrinsic viscosity.

Precisely characterize polymers by using advanced detection and analytical techniques.

Learn the importance of light scattering detection to determine the true molecular weight distribution of a poly(glutamic acid)-based copolymer for drug-delivery.

Airing 1: Thursday November 10, 2022 at 9am EST Airing 2: Thursday November 10, 2022 at 2pm EST Polymer characterization is key to understanding their properties and ensuring the quality of final products containing polymers. Discover why light scattering and viscometry in size-exclusion chromatography become the new gold standard in polymer analysis.

This application note explains how SEC coupled with MALS can be used for the determination of structural changes in polysaccharides.

Thursday, October, 20, 2022 at 9 am EDT | 3 pm CEST Do you rely on size-exclusion chromatography for the analysis of proteins? Then tune in to learn the basics of SEC and method optimization tips from our chromatography expert.

Biotherapeutics such as monoclonal antibody-derived molecules as well as their impurity profiles are becoming more complex. That challenges the routinely applied analysis of high- and low-molecular weight impurities by size exclusion chromatography and UV-absorbance. Possible limitations of SEC-UV can be overcome by adding advanced detection technologies such as multiangle light scattering (MALS) and mass spectrometry (MS). This podcast will explain the different detection methods and the results they deliver. Special emphasis will be placed on the higher requirements for size exclusion columns and methods preceding advanced detection methods.