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UHPLC Coupled with Accurate Mass and High Resolution Mass Spectrometry for Complex Environmental AnalysesEnvironmental analyses of food, soil, and water have changed dramatically over the last decade. Topics such as pesticides, food additives, and natural products have become important as food products are globally grown and distributed (1). Monitoring their quality is critical to international business. Pharmaceuticals, fluorinated surfactants, and endocrine disruptors in water are major new topics, where not only parent compounds are unknown but also their metabolites and degradation products are often more important or more abundant than the parent compound (2). New environmental issues, such as hydraulic fracturing and its wastewater, have captured our attention as the production of oil and gas has increased exponentially in the past decade (3). With this technology comes the problem of wastewater disposal and groundwater contamination. These environmental issues have greatly benefited from the combination of ultrahigh‑performance liquid chromatography (UHPLC) mated to high resolution mass spectrometry (HRMS
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The Potential of Polymer Monolithic Capillary Columns for the LC–MS Analysis of Intact ProteinsDescribes the preparation of a reversed-phase monolithic column with an optimized porous structure to separate intact proteins using LC–MS.
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Direct Analysis Serum Lipidomics Using High Performance Time of Flight Mass Spectrometry — High Resolution, Accurate Mass, and Zucker RatsPolar lipids and other metabolites extracted from plasma from lean, diabetic, and obese Zucker rats were analyzed by flow injection using high resolution time of flight mass spectrometry. Metabolites were confidently identified and differences in the metabolite profiles determined.
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Using Multiple Analytical Techniques in Non-Targeted Analysis of Food ProductsTraditional approaches for measuring food components are based on a ?target list? approach, whereby specific methodologies are developed for individual or related compounds. Such methods are well-suited for routine monitoring but can fail to detect emerging contamination events or to identify new prospects for product development.
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The Potential of Polymer Monolithic Capillary Columns for the LC–MS Analysis of Intact ProteinsDescribes the preparation of a reversed-phase monolithic column with an optimized porous structure to separate intact proteins using LC–MS.
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The Potential of Polymer Monolithic Capillary Columns for the LC–MS Analysis of Intact ProteinsDescribes the preparation of a reversed-phase monolithic column with an optimized porous structure to separate intact proteins using LC–MS.
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Monitoring Water Framework Directive Priority Substances in WastewaterThe level of pollutants present in water bodies is most commonly judged against set environmental quality standards (EQSs) that vary among different countries.
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Asymmetric Flow Field Flow Fractionation Coupled with ICP-MS for Speciation Analysis of Plasma ProteinsThis work demonstrates the potential of the simultaneous on-line hyphenation of asymmetric flow field flow fractionation (AF4) to inductively coupled plasma-mass spectrometry (ICP-MS) and ultra violet-visible/multi angle light scattering (UV-vis/MALS) detection as a promising and simple tool to obtain information on the multi-element speciation and absolute molecular mass of human plasma proteins such as albumin and transferrin: the two main proteins that have been proposed to bind and transport metal ions in this biological fluid.
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Going Beyond the Requirements of US EPA Method TO-15: Cryogen-Free Monitoring of Trace-Level “Air Toxics” at High HumidityThis study describes the gas chromatography–mass spectrometry (GC–MS) analysis of trace-level “air toxics” in humidified cannister air, using cryogen-free preconcentration technology. We show that this method is able to detect 65 target compounds ranging from propene to naphthalene, with method detection limits as low as 0.7 pptv in SIM mode, making it compliant both with standard TO-15 methods, and with “trace TO-15” methods stipulating lower detection limits.
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Polybrominated Diphenyl Ether Analysis in Fish Tissue and Other Matrices Using GC-ECDThe author describes the development of a method for the extraction, clean-up, and successful analysis of polybrominated diphenyl ethers (PBDEs) in fish tissue, soil, and water.
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What’s Your Workflow? Non-Targeted Analysis of Water SamplesAre generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.
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Rapid, Efficient Quantification of Water in Solvents and Solvents in Water Using an Ionic Liquid–Based GC ColumnDeveloping versatile, rapid, and accurate analytical techniques for the detection and quantification of water in a variety of materials remains an important and ubiquitous analytical problem. This article describes an effective and sensitive ionic liquid (IL)-based capillary gas chromatography (GC) method with thermal conductivity detection (TCD) to determine the water content in liquid samples.
Latest:
Using Multiple Analytical Techniques in Non-Targeted Analysis of Food ProductsTraditional approaches for measuring food components are based on a ?target list? approach, whereby specific methodologies are developed for individual or related compounds. Such methods are well-suited for routine monitoring but can fail to detect emerging contamination events or to identify new prospects for product development.
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Back-tracing Poultry Meat Chain Exposure to Rapidly Metabolized Pollutants Using Volatile Compound Metabolic Signatures in Liver TissuesIt is well established that food-producing animals are exposed to toxic micropollutants via environment and feeds, and that micropollutants entering the animals are transferred to edible tissues, thus representing a chemical human health hazard.
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Asymmetric Flow Field Flow Fractionation Coupled with ICP-MS for Speciation Analysis of Plasma ProteinsThis work demonstrates the potential of the simultaneous on-line hyphenation of asymmetric flow field flow fractionation (AF4) to inductively coupled plasma-mass spectrometry (ICP-MS) and ultra violet-visible/multi angle light scattering (UV-vis/MALS) detection as a promising and simple tool to obtain information on the multi-element speciation and absolute molecular mass of human plasma proteins such as albumin and transferrin: the two main proteins that have been proposed to bind and transport metal ions in this biological fluid.
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Nontargeted, Discovery-Based Profiling of the Yeast Metabolome Using QTOF LC–MS and LC–MS-MSA discovery-based, untargeted metabolomics analysis of hundreds of yeast metabolites under robust, controlled extraction conditions followed by identification is described.
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Gas Chromatography: Separation Power, Selectivity, Sensitivity, Speed, and Now....SustainabilityA chronological examination of GC is presented here, with a look at where the technique is heading and how it can be used to advance environmental sustainability.
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Simplifying Liquid ExtractionsThe benefits of supported liquid extraction (SLE) in sample cleanup and, in particular, the use of a synthetic SLE sorbent are discussed.
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The Potential of Polymer Monolithic Capillary Columns for the LC–MS Analysis of Intact ProteinsDescribes the preparation of a reversed-phase monolithic column with an optimized porous structure to separate intact proteins using LC–MS.
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Coupling Supercritical Fluid Chromatography with Evaporative Light Scattering Detection: A Study of the Relevant Parameters Ruling ResponseThe mobile-phase flow rate and the amount of modifier mixed with carbon dioxide are the main parameters affecting peak area.
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Toward Quantitative Imaging Mass SpectrometryThe main limitations of quantification using MALDI imaging are discussed and the different approaches used for quantitative measurement in MSI are evaluated.
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Nomenclature and Conventions in Comprehensive Multidimensional Chromatography – An UpdateA review of nomenclature and conventions used in comprehensive multidimensional chromatography. An update of the popular paper on this topic from 2003.
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Speciation Analysis of Mercury in Sediments by HPLC Using HPLC Hyphenated to Vapour Generation Atomic Fluorescence Spectrometry Following Microwave-Assisted ExtractionA novel method for analysing mercury in sediment is described.
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Using Automated Cold-On-Column Injection for the Analysis of Explosive Residues by Negative Chemical Ionization GC-MSNegative chemical ionization GC-MS, used in conjunction with automated cold-on-column injection, provides efficient and sensitive quantification of explosive residues for environmental and forensic applications.
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Synthesis and Applications of BEH Particles in Liquid ChromatographyHow ethylene-bridged hybrid inorganic–organic (BEH) particles are prepared and how their special qualities can be used to improve separations
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Rapid, Efficient Quantification of Water in Solvents and Solvents in Water Using an Ionic Liquid–Based GC ColumnDeveloping versatile, rapid, and accurate analytical techniques for the detection and quantification of water in a variety of materials remains an important and ubiquitous analytical problem. This article describes an effective and sensitive ionic liquid (IL)-based capillary gas chromatography (GC) method with thermal conductivity detection (TCD) to determine the water content in liquid samples.
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Analysis of Terpenes in Cannabis Using Headspace Solid-Phase Microextraction and GC–MSAs the legalization of medicinal cannabis continues to sweep across the United States, an urgent need has developed for fast, accurate and efficient analytical testing. In addition to testing for contaminants and potency, there is also interest in the determination of terpene identity and concentration levels present in different strains of cannabis. Terpenes have been shown to have therapeutic uses for treatment of different medical conditions ranging from cancer and inflammation, to anxiety and sleeplessness. It is believed that the combination of terpenes and cannabinoids in cannabis produce a synergistic effect with regards to medical benefits. The traditional testing method for terpenes in plant materials involves a solvent-based extraction followed by GC analysis. In this work, headspace solid phase microextraction (HS-SPME) was used to identify and quantify terpene content in cannabis. The HS-SPME method provided several advantages over solvent extraction in that it provided a cleaner analysis, free of interferences from co-extracted matrix, and was non-destructive to the sample. A cannabis sample of unknown origin was first analyzed qualitatively by HS-SPME and GC-MS. Spectral library matching and retention indices were used to identify 42 different terpenes. Quantitative analysis was then performed for several selected terpenes using spiked samples. Method accuracy was >90%, with reproducibility of
