Application Notes

Agilent Technologies

Wyatt Technology Corporation

Bruker Daltonics

Biotage GB Ltd

Agilent Technologies

The unique surface chemistry of the Flare diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.

High throughput analysis of amino acids has been a goal for both column and instrument manufacturers for many years.

Polyether antibiotics are commonly used for preventing coccidiosis and other infections in poultry and for improving feed efficiency for beef cattle and swine.

In this application we demonstrate the analysis of coffee and coffee products according to DIN methods. The performance of the analysis is shown for linearity, limit of detection (LOD), limit of quantification (LOQ), retention time, and area precision.

Gas chromatography coupled to high resolution time-of-flight mass spectrometry (GC–HRT) was used to identify halogenated organic compounds based on their mass defects in fish tissue extracts.

As the cost of helium increases and its availability decreases, an increasing number of Gas Chromatography (GC) professionals are considering switching to hydrogen gas for their carrier gas.

The ability to simultaneously collect quantitative and qualitative information from a DMPK analysis has the potential to significantly increase productivity in pharmaceutical drug discovery and development.

Heparin is a polydisperse, heterogeneous polysaccharide derived from animal tissue. Heparin has been used as an anticoagulant for over 60 years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution.

The use of UHPLC systems for small molecule analysis has gained widespread acceptance among researchers in recent years.

Fusel alcohols, a common byproduct of fermentation, in abnormal quantities or types can indicate alcoholic beverage adulteration.

US EPA method 529 is the procedure to determine explosives and related compounds in finished drinking water.

In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.

Chromium (Cr) is a metal with an interesting relationship to the environment. Whereas trivalent chromium (Cr(III)) is an essential nutrient, hexavalent chromium (Cr(VI)) is a poison to humans and aquatic life and poses serious environmental and ecological threats.

Analysis of polycarbonate urethanes (PCUs) are a class of biocompatible polyurethanes that show great promise for use in orthopedic implants, such as artificial hips.

Ultra high performance liquid chromatography (UHPLC) continues to grow in popularity due to highly efficient columns and fast run times, which result in excellent resolution and high throughput.

Monoamine neurotransmitters (adrenaline, dopamine, noradrenaline, and acetylcholine) are released from the brain and peripheral nervous system in minute amounts.

EPA 8270D calls for the extraction for analysis of semi-volatile analytes in various matrices. Target analytes mentioned in the method cover a wide range of compound classes resulting in reporting lists that often approach 100 compounds.

Laboratories taking in a high volume of aqueous semi-volatile samples know that every sample is different.

In the USP method for acetaminophen (1), the related compound p-aminophenol is determined using spectrophotometry while another related compound, p-chloroacetanilide, is determined using TLC.

Polymer Char

Agilent Technologies

Shimadzu Europa GmbH

Over the last decade the use of pharmaceuticals and personal care products (PPCPs) has doubled in the United States.

Degradation studies of biotherapeutic proteins are necessary to test their stability. The best way to test the suitability of a method is the use of real-time stability samples containing all relevant degradation products that might occur over time.

US EPA Method 528 determines 12 phenols in finished drinking water using solid phase extraction (SPE) and GC–MS detection.