Application Notes
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An Alternative Method to RSK 175 Using a Purge and Trap Concentrator and GC–FID
February 1st 2013Due to increased concern over the hydrofracturing process and the release of methane and other chemicals into the local drinking water, a need has developed for fast and accurate analysis of methane in water.
Accurate Mass Screening for Pesticide Residue Testing
February 1st 2013The update to the SANCO guidelines in 2009 recognized the power and potential of TOF mass spectrometry for pesticide screening applications. When compared with historical screening tools (such as the use of triple-quad mass spectrometry), high performance accurate mass TOF systems offer several advantages for screening applications.
Introducing the Hamilton PRP-C18 High-Efficiency Separations at Any pH
February 1st 2013The Hamilton PRP-C18 is a new column designed to provide high-efficiency reversed phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100 ?C), does not experience shrinkage or swelling and is completely inert to most conditions commonly encountered in reversed phase chromatography. In this study the pH stability of the PRP-C18 is evaluated. Even after prolonged exposure to concentrated (1 molar) NaOH and H2SO4 there was no measurable deterioration in performance.
Simple and Rapid MRM Method Development for Analyzing 288 Pesticides by GC–MS-MS
September 1st 2012Gas chromatography coupled with tandem mass spectrometry (GC–MS-MS) operated in MRM mode is a powerful technology for multi-residue analysis in complex food matrices. Good GC separation combined with MS-MS selectivity facilitates monitoring hundreds of MRM transitions within a short cycle time which allows for analysis of large number of compounds in complex food matrices. Nevertheless, MRM method development is time consuming and labor-intensive, which mainly comes from mapping retention time, MRM transition set-up and post-data processing.
Ultra-fast Protein Separations and High Efficiency Peptide Profiling with Agilent LC Columns
September 1st 2012Rapid and highly resolved chromatographic separations of proteins are becoming increasingly important to meet the growing demands for faster analyses, greater reliability and overall increased column performance. Additionally, highly selective and efficient separations for peptide and impurity profiling have grown among the biopharmaceutical industry, with an ever increasing need to obtain greater peak capacities.
Synthesis Monitoring and Oligomeric Analysis of PEGylated Polymers
September 1st 2012New roles and applications in the areas of science and technology are continuously being found for synthetic polymers. Specifically, the use of synthetic polymers in medicine is growing, as these polymers offer unique and versatile platforms for applications such as implants, medical devices, surgical adhesives, drug delivery vesicles, and injectable polymer-drug conjugates (1,2). As the applications of synthetic polymers increases, there is a manifested need for methods to accurately and precisely characterize the materials.
