Application Notes

Contamination of food products with pesticides is a growing concern because of recognized damaging health effects. This concern is particularly acute for baby foods because of the vulnerability of young children to harmful effects of synthetic chemicals, particularly pesticides. This application note presents results for analysis of trace levels of 24 organophosphorus (OP) pesticides in baby foods using the Shimadzu GCMS-TQ8030 triple quadrupole GC–MS-MS.

LECO Corporation

UCT, LLC

FMS Inc.

Agilent Technologies Inc.

Wyatt Technology Corporation

EMD Millipore

Polymicro Technologies, a subsidiary of Molex Inc.

PHOTONIS USA, Inc.

Wyatt Technology Corporation

Pickering Laboratories, Inc.

Malvern Instruments Ltd.

Beverages, such as sodas and energy drinks, can include a number of polar ingredients, which are easily soluble in the water matrix of the drinks. These ingredients include sweeteners (sugars and sugar substitutes), caffeine, vitamin supplements, amino acids, organic acids, and plant extracts. Because the analytes are already in solution, there is no need for extensive sample preparation. Dilution followed by direct injection into an HPLC is typically suitable.

Sample preparation for multiresidue pesticide screening for agriculture commodities can be cumbersome and laborious for multiple sample extractions. With recent advances in multiresidue pesticide screening, methods have been simplified by the introduction of QuEChERS.

Current methods to measure worker exposure to chemicals generally involve collecting samples and sending them to a laboratory for analysis, which can take up to two weeks to obtain results. Tools that can turn samples into on-site information can provide data to make informed decisions when and where they are needed to protect workers.

Tosoh Bioscience LLC

Horizon Technology, Inc.

Imtakt USA

Caramel colorings are used as additives in a broad range of food and beverage products, but have no nutritional or preservative function. Recently, the potential hazard to humans of ammonia- and ammonia-sulfite-process caramel colorings was raised, because they contain the by-product 4-methylimidazole, which is a potential carcinogen (1).

Shodex/Showa Denko America Inc.

Malvern Instruments Ltd.

Regis Technologies, Inc.

With the 1290 Infinity HDR DAD the determination of low and high dose drugs present in a fixed dose combination drug was possible in one run, due to the increased linear dynamic range by >30x.

A new type of method development that uses modeling to find the "best" separation for high performance liquid chromatography (HPLC) was investigated and principles of Quality by Design (QbD) were followed when planning the investigation. The process delivered precise results and the method was able be transferred to a routine quality control (QC) laboratory.

The update to the SANCO guidelines in 2009 recognized the power and potential of TOF mass spectrometry for pesticide screening applications.

Polyimide coated fused silica capillary tubing is widely used in the separation sciences. In this application note, we share perspectives on modifying the internal surface of capillary tubing.

A commercially available monoclonal antibody was analyzed via two different particle sizes (5 ?m and 3 ?m) and column lengths (100 mm and 30 mm) to investigate their effects on resolution and the ability to increase sample throughput.

Phthalates are plasticizers that are added to plastics to make them softer and more flexible. Plastics that contain phthalates are commonly used in the manufacturing of toys. Since phthalates are not permanently bonded to plastics, they can be released from toys through touching, licking, and chewing.

Using a novel new-design monolithic silica column (Chromolith? HighResolution RP-18e), fast, high resolution separations were achieved for various drug mixtures without the high pressures characteristic of modern particulate technology.

Sample pretreatment is often a time consuming and labor-intensive step which can be a restricting factor for the rapid analysis. This is especially true for the analysis of drugs in biofluids containing many interfering matrices.